Results 91 to 100 of about 2,579 (147)

UDP-GlcNAc Analogues as Inhibitors of O-GlcNAc Transferase (OGT):Spectroscopic, Computational, and Biological Studies [PDF]

, 2018
A series of glycomimetics of UDP-GlcNAc, in which the β-phosphate has been replaced by either an alkyl chain or a triazolyl ring and the sugar moiety has been replaced by a pyrrolidine ring, has been synthesized by the application of different click ...
Ardèvol, Beaucage, Beaucage, Burkart, Caruthers, Cipolla, Compain, del Carmen Fernandez-Alonso, Delso, Dondoni, Dorfmueller, Etzler, Finn, Gantt, Ghirardello, Gloster, Gross, Haselhorst, Horton, Hurtado-Guerrero, Izumi, Jiang, Jung, Kajimoto, Kellokumpu, Kolb, Kumari, Lazarus, Lazarus, Liang, Liang, Lira-Navarrete, Lynch, Ma, Ma, Madariaga, Mayer, Merino, Merino, Merino, Merino, Mitchell, Nagel, Ostrowski, Palcic, Pathak, Qian, Roychoudhury, Schimpl, Schutzbach, Smithen, Sun, Tedaldi, Tiwari, Trapannone, Voglmeir, Walker-Nasir, Wang, Wang, Wang, Wang, Wang, Whalen, Yeoh, Yuzwa, Zhang, Zhu, Zhu   +67 more
core   +4 more sources

Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores

Beilstein Journal of Organic Chemistry, 2014
Cyclic N-propargyl α-peptoids of various sizes were prepared by way of macrocyclizations of linear N-substituted oligoglycines. These compounds were used as molecular platforms to synthesize a series of iminosugar clusters with different valency and ...
Mathieu L. Lepage, Alessandra Meli, Anne Bodlenner, Céline Tarnus, Francesco De Riccardis, Irene Izzo, Philippe Compain   +6 more
doaj   +1 more source

Functionalization of Glycals Leading to 2-Deoxy-O-glycosides, Aminosugars, Nitrosugars and Glycosidase Inhibitors: Our Experience

CHIMIA, 2012
Glycals have been transformed into a variety of functionalized substrates which have been found to be useful in synthesizing some aminosugars, N-glycopeptides, nitrosugars and some iminosugars which are potential glycosidase inhibitors.
Rima Lahiri, Suresh Dharuman, Yashwant D. Vankar   +2 more
doaj   +1 more source

Inhibiting influenza virus replication using novel and established antiviral compounds

, 2011
Circulating influenza viruses have the potential to cause pandemics, as seen in 2009 with the emergence of a novel H1N1 virus that rapidly disseminated worldwide.
Brookes, Daniel William, Brookes, Daniel William   +1 more
core   +1 more source

Synthesis and evaluation of hepatitis C antivirals : viral E2 glycoprotein / human CD81 receptor interaction inhibitors [PDF]

, 2008
The aim of the present work was to prepare compounds which inhibit the CD81-LEL—HCV-E2 interaction by binding to CD81-LEL. Starting point was a virtual screening using the open conformation of the LEL followed by synthesis and biological validation by ...
Holzer, Marcel
core  

[[alternative]]Syntheses of 2-(Hydroxymethyl)Azepan-(4,5,6)-Triols Derivatives and the Skeleton of (-)-Stenine Alkaloid [PDF]

計畫編號：NSC94-2113-M032-006研究期間：200508~200607研究經費：1,589,000[[abstract]]當類似醣類分子中，氮原子取代了原來環內的氧原子時，這類分子被統稱為 iminosugars 或azasugars 。而它們的生物活性， 主要是抑制glycosidases 及 glycosyltranstransterase，特別針對了代謝方面的疾病，如:糖尿病、抗病毒及抗不正 當增生，已具潛在的療效。也因此，合成化學家對於合成各式樣之glycosidase 抑制 ...
施增廉
core  

Monosaccharide and Disaccharide Mimics: New Molecular Tools for Biology and Medicine

CHIMIA, 2001
Intercellular communication is governed by interactions between surface oligosaccharides and glycoproteins. The biosynthesis of these molecules involves glycosidations catalyzed by glycosyltransferases and hydrolysis of O-glycosyl linkages ...
Pierre Vogel
doaj  

<i>N</i>-Alkyl Derivatives of Deoxynojirimycin (DNJ) as Antiviral Agents: Overview and Update. [PDF]

Molecules
Checconi P, Iacopetta D, Catalano A, Ceramella J, Cavalluzzi MM, Mariconda A, Marsico S, Aquaro S, Longo P, Sinicropi MS, Lentini G.   +10 more
europepmc   +1 more source

Stereoselective Synthesis of Heavily Hydroxylated Azepane Iminosugars via Osmium-Catalyzed Tethered Aminohydroxylation. [PDF]

Org Lett, 2023
Martínez-Bailén M, Matassini C, Clemente F, Faggi C, Goti A, Cardona F.   +5 more
europepmc   +1 more source

<i>N</i>-Substitution effects on the conformations of iminosugar analogues of 1-deoxy-l-idose and 1-deoxy-l-iduronic acid. [PDF]

RSC Adv
Taglietti L, Palomba E, Lange H, Zoia L, Chiacchio MA, Legnani L, La Ferla B.   +6 more
europepmc   +1 more source