Results 21 to 30 of about 2,579 (147)

The Sweet Aspects of Orthoflavivirus Treatment Design and Vaccine Development. [PDF]

J Med Virol
ABSTRACT Viruses in the genus Orthoflavivirus are among the most important human pathogens because of their significant public health impact. Many strategies have been proposed to develop specific or broad‐spectrum treatments and preventive measures for these viral infections in humans.
Alcalá AC, Gutiérrez M, Ludert JE.
europepmc   +2 more sources

Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry [PDF]

, 2018
The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in situ biological evaluation toward α -galactosidases has been carried out.
Carmona Asenjo, Ana Teresa, Elías Rodríguez, María del Pilar, Ide, Daisuke, Kato, Atsushi, Miyawaki, Shota, Moreno Vargas, Antonio José, Pingitore, Valeria, Robina Ramírez, Inmaculada, Álvarez González, Eleuterio   +8 more
core   +1 more source

Iminosugar inhibitors of carbohydrate-active enzymes that underpin cereal grain germination and endosperm metabolism [PDF]

, 2016
Starch is a major energy store in plants. It provides most of the calories in the human diet and, as a bulk commodity, it is used across broad industry sectors.
Alison M. Smith, Andriotis, Andriotis, Aoki, Asano, Asano, Bak-Jensen, Banik, Birte Svensson, Blackwell, Boisson, Burn, Burton, Burton, Chandrasekar, Chavez Montes, Comparot-Moss, Daussant, Dinges, Fincher, Finnie, Frandsen, Gibbons, Hatzfeld, Hickes, Holdsworth, Ichinose, Kihara, Kim, Kolodziejek, Lagaert, Lee, Lee, MacGregor, Martin Rejzek, Mega, Michael D. Rugen, Moreno-Risueno, Møller, Nash, O'Brien, Rejzek, Ritchie, Robert A. Field, Ruzanski, Sissons, Slade, Smith, Smith, Sonnewald, Soussillane, Stanley, Tanaka, Vasilios M. E. Andriotis, Vriet, Wheeler, Winchester, Zeeman   +57 more
core   +2 more sources

D(-)lentiginosine-induced apoptosis involves the intrinsic pathway and is p53-independent [PDF]

, 2012
We have recently found that D(-)lentiginosine, a synthetic iminosugar exerting glucosidase inhibitory activity, but not its natural enantiomer lentiginosine, is endowed with an unexpected, pro-apoptotic activity. Here, we investigated mechanisms involved
Brandi, A, Cordero, FM, Grelli, S, Macchi, B, Marino-Merlo, F, Mastino, A, Minutolo, A   +6 more
core   +1 more source

Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors

Molecules, 2019
A series of simple C-alkyl pyrrolidines already known as cytotoxic inhibitors of ceramide glucosylation in melanoma cells can be converted into their corresponding 6-membered analogues by means of a simple ring expansion.
Cécile Baudoin-Dehoux, Tessa Castellan, Frédéric Rodriguez, Arnaud Rives, Fabien Stauffert, Virginie Garcia, Thierry Levade, Philippe Compain, Yves Génisson   +8 more
doaj   +1 more source

Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases [PDF]

, 2016
Lysosomal storage disorders (LSDs) are often caused by mutations that destabilize native folding and impair the trafficking of enzymes, leading to premature endoplasmic reticulum (ER)-associated degradation, deficiencies of specific hydrolytic functions ...
García-Fernández, José Manuel, Ortiz-Mellet, Carmen, Sánchez-Fernández, Elena M.   +2 more
core   +1 more source

A Novel Iminosugar UV-12 with Activity against the Diverse Viruses Influenza and Dengue (Novel Iminosugar Antiviral for Influenza and Dengue)

Viruses, 2015
Iminosugars are capable of targeting the life cycles of multiple viruses by blocking host endoplasmic reticulum α-glucosidase enzymes that are required for competent replication of a variety of enveloped, glycosylated viruses.
Kelly L. Warfield, Emily Plummer, Dominic S. Alonzi, Gary W. Wolfe, Aruna Sampath, Tam Nguyen, Terry D. Butters, Sven G. Enterlein, Eric J. Stavale, Sujan Shresta, Urban Ramstedt   +10 more
doaj   +1 more source

Synthesis of a New β-Galactosidase Inhibitor Displaying Pharmacological Chaperone Properties for GM1 Gangliosidosis

Molecules, 2022
GM1 gangliosidosis is a rare lysosomal disease caused by the deficiency of the enzyme β-galactosidase (β-Gal; GLB1; E.C. 3.2.1.23), responsible for the hydrolysis of terminal β-galactosyl residues from GM1 ganglioside, glycoproteins, and ...
Francesca Clemente, Macarena Martínez-Bailén, Camilla Matassini, Amelia Morrone, Silvia Falliano, Anna Caciotti, Paolo Paoli, Andrea Goti, Francesca Cardona   +8 more
doaj   +1 more source

Conformationally-Locked C-Glycosides: Tuning Aglycone Interactions for Optimal Cheperone Behaviour in Gaucher Fibroblasts [PDF]

, 2016
A series of conformationally locked C-glycosides based on the 3-aminopyrano[3,2-b]pyrrol-2(1H)-one (APP) scaffold has been synthesized. The key step involved a totally stereocontrolled C-Michael addition of a serine-equivalent C-nucleophile to tri-O ...
Avenoza, A., Busto, J.H., Corzana, F., García Fernández, José Manuel, Higaki, Katsumi, Namba, E., Navo, C.D., Ortiz Mellet, Carmen, Peregrina, J.M., Sánchez Fernández, Elena Matilde   +9 more
core   +1 more source

Toward the Identification of Novel Antimicrobial Agents: One-Pot Synthesis of Lipophilic Conjugates of N-Alkyl d- and l-Iminosugars

Marine Drugs, 2020
In the effort to improve the antimicrobial activity of iminosugars, we report the synthesis of lipophilic iminosugars 10a–b and 11a–b based on the one-pot conjugation of both enantiomeric forms of N-butyldeoxynojirimycin (NBDNJ) and N ...
Anna Esposito, Daniele D’Alonzo, Stefano D’Errico, Eliana De Gregorio, Annalisa Guaragna   +4 more
doaj   +1 more source