Results 51 to 60 of about 2,579 (147)
The transformative power of structural predictions with AI in plant science
The Plant Journal, Volume 125, Issue 6, March 2026.SUMMARY Since the introduction of various structural prediction programs, the emerging transformative power of these technologies in plant science is apparent. Not only programs like AlphaFold but also RoseTTAFold, Chai‐1 and Boltz suddenly enable plant scientists to predict structures with high confidence. This ability has facilitated the discovery of
Joy Chenqu Lyu +1 more
wiley +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. Compounds are comprised of three key structural motifs: the iminosugar, for interaction with cholinesterase catalytic anionic site (
Ana I. Ahuja-Casarín +9 more
doaj +1 more source
Asian Journal of Organic Chemistry, Volume 15, Issue 2, February 2026.Simple access to alkylated 3D scaffold via oxidative radical decarboxylation, trapping of iminium, and successive reaction with organometallic reagent in the presence of BF3 . ABSTRACT Cyclic amines are vital scaffolds in bioactive molecules and drug discovery, often functionalized via electrochemical Shono‐type oxidation to access N‐acyliminium ...
Dario Corbisiero +7 more
wiley +1 more source
Molecules, 2021 An efficient method for the synthesis of nojirimycin- and pyrrolidine-based iminosugar derivatives has been developed. The strategy is based on the partial reduction in sugar-derived lactams by Schwartz’s reagent and tandem stereoselective nucleophilic ...
Piotr Szcześniak +2 more
doaj +1 more source
Biotechnology and Bioengineering, Volume 123, Issue 2, Page 310-323, February 2026.ABSTRACT Clostridioides difficile infection presents an escalating clinical challenge due to the proliferation of hypervirulent and antibiotic‐resistant strains. The primary symptoms of disease, namely colitis and diarrhea, are induced by the release of two toxins: TcdA and TcdB.
Carly M. Catella +10 more
wiley +1 more source
Synthesis of fused tetrazolo iminosugars from azido monosaccharide derivatives [PDF]
, 2014 Synthesis of fused tetrazolo iminosugars from azido monosaccharide derivativesUniversidad de Málaga.
Pino-Gonzalez, Maria Soledad
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Therapeutic Effects of Nizubaglustat in a Mouse Model of GM2 Gangliosidosis
Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.ABSTRACT Nizubaglustat is a novel selective inhibitor of glucosylceramide synthase (GCS) and the non‐lysosomal glucocerebrosidase (NLGase, GbA2) with brain penetrant properties. It is currently in clinical development as an oral treatment for rare lysosomal storage diseases with neurological involvement. One such disease group called GM2 gangliosidosis,
Kyle Landskroner +3 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2015 The synthesis and photophysical properties of the first examples of iminosugar clusters based on a BODIPY or a pyrene core are reported. The tri- and tetravalent systems designed as molecular probes and synthesized by way of Cu(I)-catalysed azide–alkyne ...
Mathieu L. Lepage +6 more
doaj +1 more source
Pharmaceuticals, 2019 Here, the synthesis and glycosidase inhibition properties of the two first known 3-ethyloctahydro-1H-indole-4,5,6-triols are reported. This study shows the transformation of d-glucose into polyhydroxylated 1-(2-nitrocyclohexane) acetaldehydes, followed ...
Juan C. Estévez +7 more
doaj +1 more source
ChemBioChem, Volume 26, Issue 23, November 27, 2025.An N‐galactosyl aziridine is found to have μM range mixed inhibition constants (K i and K i’) for a fungal β‐galactosidase. Aziridine‐bearing cyclic polyols are established as irreversible covalent inhibitors of glycosyl hydrolases and have been employed as activity‐based probes.
Aaron McCormack +3 more
wiley +1 more source