Results 71 to 80 of about 2,579 (147)

N-2 Alkylated analogues of aza-galactofagomine as potential inhibitors of β-glucosidase [PDF]

Journal of the Serbian Chemical Society
The synthesis of four N-2-alkylated aza-galactofagomine (AGF) analogues was achieved by intermolecular reductive hydrazination or alkylation of suitably protected AGF. The synthesized compounds were evaluated as potential β-glucosidase inhibitors.
Đurković Filip, Zlatović Mario, Sladić Dušan, Novaković Irena, Bihelović Filip, Ferjančić Zorana   +5 more
doaj   +1 more source

N-Nonyloxypentyl-l-Deoxynojirimycin Inhibits Growth, Biofilm Formation and Virulence Factors Expression of Staphylococcus aureus

Antibiotics, 2020
Staphylococcus aureus is one of the major causes of hospital- and community-associated bacterial infections throughout the world, which are difficult to treat due to the rising number of drug-resistant strains.
Eliana De Gregorio, Anna Esposito, Adriana Vollaro, Maria De Fenza, Daniele D’Alonzo, Antonella Migliaccio, Vita Dora Iula, Raffaele Zarrilli, Annalisa Guaragna   +8 more
doaj   +1 more source

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2021–2022

Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.
Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley   +1 more source

Flavonoids with α-glucosidase inhibitory activities and their contents in the leaves of Morus atropurpurea [PDF]

, 2013
BACKGROUND: This study aims to isolate the α-glucosidase inhibitory compounds from mulberry leaves (Morus atropurpurea Roxb., Moraceae) and to develop an analytical method for quantification of the compounds.
Hin-Chu Hong, Qing-Wen Zhang, Song-Lin Li, Wen-Cai Ye, Xiao-Qi Zhang   +4 more
core   +1 more source

Expansion of the diversity of dispersin scaffolds

Acta Crystallographica Section D, Volume 81, Issue 3, Page 130-146, March 2025.
Five GH20‐family dispersins were characterized for activity on aryl glycosides and poly‐β‐1,6‐linked N‐acetyl‐d‐glucosamine oligomers and three crystal structures were solved, including two complexes with bound inhibitors.Microorganisms are known to secrete copious amounts of extracellular polymeric substances (EPS) that form complex matrices around ...
Alexandra Males, Olga V. Moroz, Elena Blagova, Astrid Munch, Gustav H. Hansen, Annette H. Johansen, Lars H. Østergaard, Dorotea R. Segura, Alexander Eddenden, Anne V. Due, Martin Gudmand, Jesper Salomon, Sebastian R. Sørensen, João Paulo L. Franco Cairo, Mark Nitz, Roland A. Pache, Rebecca M. Vejborg, Sandeep Bhosale, David J. Vocadlo, Gideon J. Davies, Keith S. Wilson   +20 more
wiley   +1 more source

Mulberry extract to modULate Blood glucosE Responses in noRmoglYcaemic adults (MULBERRY): study protocol for a randomized controlled trial [PDF]

, 2015
Background: worldwide sugar consumption has tripled during the last fifty years. High sugar intake is associated with weight gain and increased incidence of diabetes and has been linked with increased cardiovascular mortality.
Byrne, C., Fraser, A., Fuller, R., Gallagher, A., Lewith, G., Lightowler, H., Lown, M., Stuart, B.   +7 more
core   +1 more source

Evaluation of the Landscape of Pharmacodynamic Biomarkers in GM1 and GM2 Gangliosidosis

Clinical and Translational Science, Volume 18, Issue 3, March 2025.
ABSTRACT GM1 and GM2 gangliosidosis are inherited, progressive, neurodegenerative lysosomal disorders of variable onset and disease progression. GM1 gangliosidosis is a result of biallelic pathogenic variants in the GLB1 gene, which confer absent or reduced β‐galactosidase enzyme activity and lead to the accumulation of glycoconjugates such as ...
Sydney Stern, Karryn Crisamore, Ruo‐Jing Li, Michael Pacanowski, Robert Schuck   +4 more
wiley   +1 more source

Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies

Journal of Enzyme Inhibition and Medicinal Chemistry
We developed new iminosugar-based glycosidase inhibitors against SARS-CoV-2. Known drugs (miglustat, migalastat, miglitol, and swainsonine) were chosen as lead compounds to develop three classes of glycosidase inhibitors (α-glucosidase, α-galactosidase ...
Zorana Ferjancic, Filip Bihelovic, Bojan Vulovic, Radomir Matovic, Milena Trmcic, Aleksandar Jankovic, Milos Pavlovic, Filip Djurkovic, Radivoje Prodanovic, Aleksandra Djurdjevic Djelmas, Nevena Kalicanin, Mario Zlatovic, Dusan Sladic, Thomas Vallet, Marco Vignuzzi, Radomir N. Saicic   +15 more
doaj   +1 more source

Research on pharmacological chaperone for β-N-acetylhexosaminidase [PDF]

, 2016
富山大学・富医薬博甲第205号・中川 進平・2016/03 ...
中川 進平
core   +1 more source

(Z)-N-(2-Iodophenyl)-4-nitrobenzimidoyl cyanide [PDF]

, 2016
In the title molecule, C14H8IN3O2, the cyanide group is anti to the iodide substituent of the adjacent benzene ring. The central segment is essentially planar (r.m.s deviation = 0.0341 A ° ) and it is twisted away from the iodide- and nitro-substituted ...
Abonia, Rodrigo, Garcia, Andres C, Jaramillo-Gomez, Luz M, Kennedy, Alan R., Moreno-Fuquen, Rodolfo   +4 more
core   +2 more sources