European Journal of Organic Chemistry, Volume 28, Issue 6, February 10, 2025.A series of novel aminoindolizidines fused to (tetrahydro)furan, thiophene or pyrrole nuclei were synthesized using a concise and diastereoselective approach from optically pure tricyclic heteroaryl‐indolizidinols as key substrates. The synthesis involved Jurjew‐type skeletal rearrangement, Staudinger reduction, Thompson azidation and Ra−Ni mediated ...
Paula Fraňová +5 more
wiley +1 more source
Highly diastereoselective synthesis of aza-diels-alder reaction of danishefsky diene wiht glyoxylate imines [PDF]
, 2012 Aza-Diels-Alder reaction is an exceptionally powerful synthetic method for the construction of six-membered nitrogen-heterocycles.[1-3] The reaction of Danishefsky's diene 1 with iminoacetates 2 (imines of glyoxylates) provides a convenient protocol for ...
Alves, M. José +2 more
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6-Deoxyhexoses froml-Rhamnose in the Search for Inducers of the Rhamnose Operon: Synergy of Chemistry and Biotechnology [PDF]
, 2016 In the search for alternative non‐metabolizable inducers in the l ‐rhamnose promoter system, the synthesis of fifteen 6‐deoxyhexoses from l ‐rhamnose demonstrates the value of synergy between biotechnology and chemistry.
Estévez, Amalia +12 more
core +3 more sources
Molecules, 2018 This work aims to synthesize new trehalase inhibitors selective towards the insect trehalase versus the porcine trehalase, in view of their application as potentially non-toxic insecticides and fungicides.
Giampiero D’Adamio +7 more
doaj +1 more source
Natural products with therapeutic potential in melanoma metastasis [PDF]
, 2015 Malignant melanoma is the most aggressive form of skin cancer and accounts for about 3% of all cases of malignant tumour. Its incidence is increasing worldwide and it is becoming resistant to current therapeutic agents.
AlQathama, A, Prieto, JM
core +1 more source
Stereoselectively fluorinated N-heterocycles: a brief survey
Beilstein Journal of Organic Chemistry, 2013 The stereoselective incorporation of fluorine atoms into N-heterocycles can lead to dramatic changes in the molecules’ physical and chemical properties.
Xiang-Guo Hu, Luke Hunter
doaj +1 more source
Anwendungen der Olefinmetathese in der Synthese von Azazuckern [PDF]
, 2000 Anwendungen der Olefinmetathese in der Synthese von Azazuckern Polyhydroxylierte Derivate monocyclischer und bicyclischer stickstoffhaltiger Ringsysteme, wie z.B.
Voigtmann, Ulrike
core +1 more source
Synthesis and biological evaluation of nojirimycin- and pyrrolidine-based trehalase inhibitors
Beilstein Journal of Organic Chemistry, 2012 A small set of nojirimycin- and pyrrolidine-based iminosugar derivatives has been synthesized and evaluated as potential inhibitors of porcine and insect trehalases.
Davide Bini +6 more
doaj +1 more source
Therapeutic strategies based on modified U1 snRNAs and chaperones for Sanfilippo C splicing mutations [PDF]
, 2015 Mutations affecting RNA splicing represent more than 20% of the mutant alleles in Sanfilippo syndrome type C, a rare lysosomal storage disorder that causes severe neurodegeneration. Many of these mutations are localized in the conserved donor or acceptor
Alves, Sandra +11 more
core +1 more source
The synthesis of an homochiral aziridine as a useful synton to iminosugars and amino acid compounds [PDF]
, 2011 Fundação para a Ciência e a Tecnologia (FCT) - PTDC/QUI/67407 ...
Alves, M. José +4 more
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