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The Glycosylation of Immune Checkpoints and Their Applications in Oncology
Pharmaceuticals, 2022 Tumor therapies have entered the immunotherapy era. Immune checkpoint inhibitors have achieved tremendous success, with some patients achieving long-term tumor control.
Linlin Zheng +10 more
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Clinical Research on the Mechanisms Underlying Immune Checkpoints and Tumor Metastasis
Frontiers in Oncology, 2021 This study highlights aspects of the latest clinical research conducted on the relationship between immune checkpoints and tumor metastasis. The overview of each immune checkpoint is divided into the following three sections: 1) structure and expression;
Xi-Yang Tang +7 more
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Harnessing the immune system by targeting immune checkpoints: Providing new hope for Oncotherapy
Frontiers in Immunology, 2022 With the goal of harnessing the host’s immune system to provide long-lasting remission and cures for various cancers, the advent of immunotherapy revolutionized the cancer therapy field.
Lu Yu +6 more
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Immune checkpoints in immune response to glioma: two sides of the same coin [PDF]
Frontiers in ImmunologyGliomas are aggressive brain tumors of glial origin accounting for about 80% of the central nervous system (CNS) malignancies. Glioma cells are known to form a highly immunosuppressive tumor microenvironment (TME) capable of inhibiting T cell activation ...
Oxana Musatova +4 more
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Functional interaction between immune checkpoints and lipid metabolism in the development of arteriosclerosis obliterans [PDF]
Frontiers in ImmunologyArteriosclerosis obliterans (ASO) is a chronic vascular disease characterized by narrowing or occlusion of the vascular lumen. Its pathogenesis is complex and closely associated with lipid metabolism disorders and chronic inflammation.
Junyi Zhang +14 more
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Cell Communication and Signaling, 2023 Acute myeloid leukemia (AML) comprises a multifarious and heterogeneous array of illnesses characterized by the anomalous proliferation of myeloid cells in the bone marrow microenvironment (BMM). The BMM plays a pivotal role in promoting AML progression,
Maryam Bakhtiyari +12 more
doaj +2 more sources
Natural Killer Cell Immune Checkpoints and Their Therapeutic Targeting in Cancer Treatment. [PDF]
Research (Wash D C)Natural killer (NK) cells, serving as pivotal mediators of innate immunity, play an important role in antitumor immunity. Immune checkpoint can be expressed on the surface of NK cells and meticulously regulates their activation states and effector ...
Lin A +7 more
europepmc +2 more sources
Immune Checkpoints in Viral Infections
Viruses, 2020 As evidence has mounted that virus-infected cells, such as cancer cells, negatively regulate the function of T-cells via immune checkpoints, it has become increasingly clear that viral infections similarly exploit immune checkpoints as an immune system ...
Huiming Cai +11 more
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Scientific Reports, 2021 We established a relationship among the immune-related genes, tumor-infiltrating immune cells (TIICs), and immune checkpoints in patients with osteosarcoma. The gene expression data for osteosarcoma were downloaded from UCSC Xena and GEO database. Immune-
Tuo Liang +13 more
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Patients with peripheral artery disease demonstrate altered expression of soluble and membrane-bound immune checkpoints [PDF]
Frontiers in ImmunologyIntroductionStudies suggest that immune checkpoints play a role in accelerating the formation of atherosclerosis. We aimed to assess the expression of soluble and membrane-bound immune checkpoints in patients with peripheral artery disease (PAD ...
Rosanne D. Reitsema +8 more
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