Results 11 to 20 of about 1,989,151 (330)
Post-translational modifications of cancer immune checkpoints: mechanisms and therapeutic strategies [PDF]
Molecular CancerImmunotherapies, particularly immune checkpoint inhibitors (ICIs), have revolutionized cancer clinical management, but low response rates and treatment resistance remain challenging.
Haiqing Jia +9 more
doaj +2 more sources
Immune checkpoints and ncRNAs: pioneering immunotherapy approaches for hematological malignancies [PDF]
Cancer Cell InternationalHematological malignancies are typically treated with chemotherapy and radiotherapy as the first-line conventional therapies. However, non-coding RNAs (ncRNAs) are a rapidly expanding field of study in cancer biology that influences the growth ...
Samira Anvari +4 more
doaj +2 more sources
Immune checkpoint inhibitors [PDF]
Journal of Cell Biology, 2019 Hui details the cell biology underlying the action of immune checkpoint inhibitors.
Pawel Kalinski, Per Basse
+11 more sources
Immune checkpoint inhibitors [PDF]
Journal of Experimental Medicine, 2021 Three papers by James Allison and Tasuku Honjo published in JEM between 1995 and 2000 crystallized seminal insights into the role of CTLA-4 and PD-1 in immunosuppression (Krummel and Allison. 1995. J. Exp. Med.https://doi.org/10.1084/jem.182.2.459; van Elsas et al. 1999. J. Exp. Med.https://doi.org/10.1084/jem.190.3.355; Freeman et al. 2000. J.
Kroemer, Guido, Zitvogel, Laurence
+6 more sources
The Latest Look at PDT and Immune Checkpoints [PDF]
Current Issues in Molecular BiologyPhotodynamic therapy (PDT) can not only directly eliminate cancer cells, but can also stimulate antitumor immune responses. It also affects the expression of immune checkpoints. The purpose of this review is to collect, analyze, and summarize recent news
David Aebisher +2 more
doaj +2 more sources
Current Progress and Future Perspectives of Immune Checkpoint in Cancer and Infectious Diseases
Frontiers in Genetics, 2021 The inhibitory regulators, known as immune checkpoints, prevent overreaction of the immune system, avoid normal tissue damage, and maintain immune homeostasis during the antimicrobial or antiviral immune response.
Xin Cai +6 more
doaj +1 more source
Cell Death and Disease, 2023 The tumor microenvironment (TME) is a highly intricate milieu, comprising a multitude of components, including immune cells and stromal cells, that exert a profound influence on tumor initiation and progression.
Jianwen Fang +7 more
semanticscholar +1 more source
Diversity of immune checkpoints in cancer immunotherapy
Frontiers in Immunology, 2023 Finding effective treatments for cancer remains a challenge. Recent studies have found that the mechanisms of tumor evasion are becoming increasingly diverse, including abnormal expression of immune checkpoint molecules on different immune cells, in ...
Zhangyan Guo +3 more
semanticscholar +1 more source
Immune Checkpoint Inhibitors [PDF]
JAMA Oncology, 2015 Undoubtedly the discovery of immune checkpoints such as CTLA-4 and PD-1 has been crucial to the development of cancer immunotherapy. Although these molecules were originally discovered as molecules playing a role in T cell activation or apoptosis, subsequent preclinical research showed their important role in the maintenance of peripheral immune ...
John B A G, Haanen, Caroline, Robert
openaire +3 more sources
Targeting immune checkpoints on tumor-associated macrophages in tumor immunotherapy
Frontiers in Immunology, 2023 Unprecedented breakthroughs have been made in cancer immunotherapy in recent years. Particularly immune checkpoint inhibitors have fostered hope for patients with cancer.
Shumin Xu +8 more
semanticscholar +1 more source