Results 21 to 30 of about 1,989,151 (330)
Expression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneity. [PDF]
, 2020 Although immunotherapies have achieved remarkable salutary effects among subgroups of advanced cancers, most patients do not respond. We comprehensively evaluated biomarkers associated with the "cancer-immunity cycle" in the pan-cancer setting in order ...
Dressman, Devin +13 more
core +1 more source
Immune checkpoints and cancer immunotherapies: insights into newly potential receptors and ligands
Therapeutic Advances in Vaccines and Immunotherapy, 2023 Checkpoint markers and immune checkpoint inhibitors have been increasingly identified and developed as potential immunotherapeutic targets in various human cancers.
A. N. Kamali +3 more
semanticscholar +1 more source
Emerging phagocytosis checkpoints in cancer immunotherapy
Signal Transduction and Targeted Therapy, 2023 Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as it utilizes patients’ own immune systems in combating the cancer cells.
Yu’e Liu +9 more
doaj +1 more source
Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer
Journal of experimental & clinical cancer research : CR, 2021 The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)/B7 and programmed death 1 (PD-1)/ programmed cell death-ligand 1 (PD-L1) are two most representative immune checkpoint pathways, which negatively regulate T cell immune function during different ...
Hao Zhang +8 more
semanticscholar +1 more source
Blockade of novel immune checkpoints and new therapeutic combinations to boost antitumor immunity
Journal of experimental & clinical cancer research : CR, 2022 Immunotherapy has emerged as a promising strategy for boosting antitumoral immunity. Blockade of immune checkpoints (ICs), which regulate the activity of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells has proven clinical benefits ...
Adrià Archilla-Ortega +3 more
semanticscholar +1 more source
Acta Pharmaceutica Sinica B, 2021 Immune checkpoints are the crucial regulators of immune system and play essential roles in maintaining self-tolerance, preventing autoimmune responses, and minimizing tissue damage by regulating the duration and intensity of the immune response ...
Yuli Wang +10 more
doaj +1 more source
Immune Checkpoints: Novel Therapeutic Targets to Attenuate Sepsis-Induced Immunosuppression
Frontiers in Immunology, 2021 Sepsis is a leading cause of death in intensive care units and survivors develop prolonged immunosuppression and a high incidence of recurrent infections.
M. A. McBride +5 more
semanticscholar +1 more source
Zeb1 induces immune checkpoints to form an immunosuppressive envelope around invading cancer cells
Science Advances, 2021 Zeb1-induced immune checkpoints promote M2 macrophages and protect invading lung cancer cells from inflammatory cells. The PDL1-PD1 immune checkpoint inhibits T cell activation, and its blockade is effective in a subset of patients.
Yan Guo +9 more
semanticscholar +1 more source
Targeting immune checkpoints: how to use natural killer cells for fighting against solid tumors
Cancer Communications, 2022 Natural killer (NK) cells are unique innate immune cells that mediate anti‐viral and anti‐tumor responses. Thus, they might hold great potential for cancer immunotherapy. NK cell adoptive immunotherapy in humans has shown modest efficacy.
Farhoodeh Ghaedrahmati +2 more
semanticscholar +1 more source
Pharmaceuticals, 2022 Numerous research reports have witnessed dramatic advancements in cancer therapeutic approaches through immunotherapy. Blocking immunological checkpoint pathways (mechanisms employed by malignant cells to disguise themselves as normal human body ...
P. Pandey +5 more
semanticscholar +1 more source