Results 41 to 50 of about 8,040 (174)

Coupling of Single Molecule, Long Read Sequencing with IMGT/HighV-QUEST Analysis Expedites Identification of SIV gp140-Specific Antibodies from scFv Phage Display Libraries

Frontiers in Immunology, 2018
The simian immunodeficiency virus (SIV)/macaque model of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome pathogenesis is critical for furthering our understanding of the role of antibody responses in the prevention of HIV infection,
Seung Yub Han, Alesia Antoine, David Howard, Bryant Chang, Woo Sung Chang, Matthew Slein, Gintaras Deikus, Sofia Kossida, Patrice Duroux, Marie-Paule Lefranc, Robert P. Sebra, Melissa L. Smith, Ismael Ben F. Fofana   +12 more
doaj   +1 more source

Modeling TCR‐Epitope Recognition Specificity: What We Should Learn to Succeed

Immunological Reviews, Volume 340, Issue 1, July 2026.
ABSTRACT T‐cell recognition of infected or malignant cells is central to both spontaneous and therapy‐induced cellular immune responses against pathogens and cancer. This recognition is elicited by the interaction between T‐Cell Receptors (TCRs) and epitopes, which consist of antigenic peptides displayed on major histocompatibility complex molecules ...
David Gfeller, Julien Racle, Rita Ann Roessner   +2 more
wiley   +1 more source

IMGT-ONTOLOGY for Immunogenetics and Immunoinformatics

, 2004
IMGT, the international ImMunoGeneTics information system® (http://imgt.cines.fr), is a high quality integrated knowledge resource specializing in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) and related proteins of
Thouvenin, Valérie, Combres, Kora, Chaume, Denys, Jabado-Michaloud, Joumana, Duprat, Elodie, Bosc, Nathalie, Lefranc, Gérard, Ginestoux, Chantal, Giudicelli, Véronique, Scaviner, Dominique, Jeanjean, Stéphanie, Guiraudou, Delphine, Protat, Céline, Kaas, Quentin, Monod, Mehdi Yousfi, Pommié, Christelle, Girod, David, Magris, Séverine, Lefranc, Marie-Paule, Folch, Géraldine   +19 more
core   +2 more sources

Novel alleles in the era of next-generation sequencing-based HLA typing calls for standardization and policy

Frontiers in Genetics, 2023
Next-Generation Sequencing (NGS) has transformed clinical histocompatibility laboratories through its capacity to provide accurate, high-throughput, high-resolution typing of Human Leukocyte Antigen (HLA) genes, which is critical for transplant safety ...
Jenny N. Tran, Karen R. Sherwood, Ahmed Mostafa, Rey Vincent Benedicto, Allaa ElaAlim, Anna Greenshields, Paul Keown, Robert Liwski, James H. Lan   +8 more
doaj   +1 more source

Full‐Length Next‐Generation Sequencing of 11 HLA Loci of More Than 1000 Individuals From Clinical Cohorts in East and West Africa

HLA, Volume 108, Issue 1, July 2026.
ABSTRACT HLA loci have been implicated in several diseases, including HIV‐1, from different world populations. It is necessary to characterise HLA allele variation at the population level prior to investigating associations linked to human diseases. In global databases, limited high‐resolution HLA allele types generated by next‐generation sequencing ...
Yvonne V. Rosario, Aviva Geretz, Lakshmi Rani Iyer, Philip K. Ehrenberg, Alýa Tyson, Hannah Kibuuka, Fred Wabwire‐Mangen, Lucas Maganga, Abdulwasiu Tiamiyu, Jonah Maswai, Josphat Kosgei, Frederick Sawe, Gary R. Matyas, Merlin L. Robb, Julie A. Ake, Rasmi Thomas   +15 more
wiley   +1 more source

IMGT-ONTOLOGY

, 2013
International audienceIMGT-ONTOLOGY is the ontology for immunogenetics and immunoinformatics. IMGT-ONTOLOGY, created to manage the complexity of immunogenetics knowledge, is the first ontology and global reference in the domain.
Marie-Paule Lefranc, Giudicelli, Véronique, Véronique Giudicelli, Lefranc, Marie-Paule   +3 more
core   +1 more source

3D structures inferred from cDNA clones identify the CD1D-Restricted γδ T cell receptor in dromedaries

Frontiers in Immunology, 2022
The Camelidae species occupy an important immunological niche within the humoral as well as cell mediated immune response. Although recent studies have highlighted that the somatic hypermutation (SHM) shapes the T cell receptor gamma (TRG) and delta (TRD)
Giovanna Linguiti, Vincenzo Tragni, Ciro Leonardo Pierri, Serafina Massari, Marie-Paule Lefranc, Rachele Antonacci, Salvatrice Ciccarese   +6 more
doaj   +1 more source

IMGT® at scale: FAIR, dynamic, and automated tools for immune locus analysis. [PDF]

Nucleic Acids Res
International audienceIMGT ® , the international ImMunoGeneTics information system ® , has advanced its comprehensive platform for the analysis of immunoglobulin (IG) and T-cell receptor (TR) genes through the de v elopment of ne w automated and scalable
Sanou G, Zeitoun G, Manso T, Eidi M, Batool S, Kushwaha A, Grand F, Croze M, Vaillant A, Debbagh C, Abdollahi N, Georga M, Papadaki A, Sideri I, Samadova T, Jabado-Michaloud J, Folch G, Giudicelli V, Duroux P, Kossida S.   +19 more
europepmc   +2 more sources

Pacific Biosciences Sequencing and IMGT/HighV-QUEST Analysis of Full-Length Single Chain Fragment Variable from an In Vivo Selected Phage-Display Combinatorial Library

Frontiers in Immunology, 2017
Phage-display selection of immunoglobulin (IG) or antibody single chain Fragment variable (scFv) from combinatorial libraries is widely used for identifying new antibodies for novel targets.
Audrey Hemadou, Véronique Giudicelli, Melissa Laird Smith, Marie-Paule Lefranc, Patrice Duroux, Sofia Kossida, Cheryl Heiner, N. Lance Hepler, John Kuijpers, Alexis Groppi, Jonas Korlach, Philippe Mondon, Florence Ottones, Marie-Josée Jacobin-Valat, Jeanny Laroche-Traineau, Gisèle Clofent-Sanchez   +15 more
doaj   +1 more source

Human Leukocyte Antigen DQ (HLA‐DQ) genotypes and haplotypes and their association with phenotype in patients with celiac disease in India

JGH Open, 2021
Background and Aim Human Leukocyte Antigen DQ (HLA‐DQ) genotypes play a permissive role in the genesis of celiac disease (CeD). In this case–control study, we used next‐generation sequencing to determine HLA‐DQA1 and ~DQB1 genotypes and haplotypes ...
Balakrishnan S Ramakrishna, Giriprasad Venugopal, Alka Singh, Srinivasan Pugazhendhi, Sangitanjan Dutta, Vineet Ahuja, Govind K Makharia   +6 more
doaj   +1 more source