Results 61 to 70 of about 8,040 (174)

High‐Resolution NGS HLA Typing Identifies Specific Class II–Dominant Risk Haplotypes and HLA LD Structure in Acute Lymphoblastic Leukaemia Among Ethnic Kazakhs

HLA, Volume 107, Issue 6, June 2026.
ABSTRACT Acute lymphoblastic leukaemia (ALL) results from the uncontrolled growth of lymphoid progenitors, yet the immunogenetic factors behind this remain poorly understood. A connection between specific HLA alleles, multi‐locus haplotypes and ALL predisposition was suggested, with an ethnic component to this association.
Zhandos Burkitbayev, Aida Turganbekova, Zhulduz Zhanzakova, Dana Baimukasheva, Zhazira Saduakas, Didara Khamitova, Saniya Abdrakhmanova, Zhaksylyk Masalimov, Wassim Y. Almawi   +8 more
wiley   +1 more source

Identification of engineered IMGT Fc variants in IMGT/mAb-DB, a database of therapeutic antibodies and fusion proteins

mAbs
Monoclonal antibodies (mAbs) and fusion proteins for immune applications (FPIA) play a crucial role in treating autoimmune diseases and cancers by targeting cell-surface proteins and triggering multiple immune mechanisms.
Taciana Manso, Gaoussou Sanou, Christos Nousias, Imene Maalem, François Boutin, Véronique Giudicelli, Patrice Duroux, Marie-Paule Lefranc, Sofia Kossida   +8 more
doaj   +1 more source

Unfavourable H‐CDR3 Loops in preB Cells Lead to Highly Expanded Plasma Cell Clones

European Journal of Immunology, Volume 56, Issue 5, May 2026.
In the absence of a pre‐BCR, a subset of mature B cells that expresses IgH chains with very short, hydrophobic and positively charged H‐CDR3 loops is generated. This results in massive clonal expansion and the development of autoreactive plasma cells exhibiting these characteristics.
Alaitz Aranburu, Erik Engström, Erik Demitz‐Helin, Julia M. Scheffler, Alessandro Camponeschi, Timothy Sundell, Zhong Ni, Inga‐Lill Mårtensson   +7 more
wiley   +1 more source

Primer sets for cloning the human repertoire of T cell Receptor Variable regions

BMC Immunology, 2008
Background Amplification and cloning of naïve T cell Receptor (TR) repertoires or antigen-specific TR is crucial to shape immune response and to develop immuno-based therapies.
Santoro Claudio, Dianzani Irma, Cotella Diego, Boria Ilenia, Sblattero Daniele   +4 more
doaj   +1 more source

HLA Class II Protein Expression Regulation Is Strongly Linked to Cis‐Acting SNPs

HLA, Volume 107, Issue 4, April 2026.
ABSTRACT Allele‐specific variability in HLA class I gene expression levels has been associated with many diseases. Although expression variation at the allelic level has not been well‐characterised for the HLA class II genes, differential expression of these genes, as marked by single nucleotide polymorphisms (SNPs), has been implicated in the outcome ...
Nicolas Vince, Veron Ramsuran, Mathias Viard, Jeremy Martinson, Steven Wolinsky, Shehnaz Hussain, Eric C. Seaberg, Todd T. Brown, Niamh Spence, Chloe L. Thio, James J. Goedert, W. Keith Hoots, Gregory D. Kirk, Mary Carrington   +13 more
wiley   +1 more source

The Phenotype List String Grammar for Enhanced Protein and Antigen Reporting in the Immunogenetic Context

HLA, Volume 107, Issue 4, April 2026.
ABSTRACT Standardised data representation is fundamental to the integrity, interoperability and reproducibility of immunogenetics and histocompatibility testing. While well‐established standards such as the genotype list (GL) String, histoimmunogenetics markup language (HML) and minimum information for reporting next‐generation sequence genotyping ...
Steven J. Mack, Nicholas K. Brown, Loren Gragert, Jan A. Hofmann, William Lemieux, Benedict M. Matern, Kazutoyo Osoegawa, Jürgen Sauter, Martin Maiers, Eric Spierings   +9 more
wiley   +1 more source

IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling [PDF]

, 2013
T cell repertoire diversity and clonotype follow-up in vaccination, cancer, infectious and immune diseases represent a major challenge owing to the enormous complexity of the data generated.
Burrows, Scott R., Gowans, E., Corbin, Vincent D.A., Freeman, J Douglas, Papenfuss, Anthony, Scheerlinck, J. P., Burrows, S, Scheerlinck, J., Papenfuss, A., Papenfuss, A. T., Corbin, Vincent D. A., Alamyar, Eltaf, Burrows, SR, Freeman, J. Douglas, Corbin, Vincent, Duroux, P., Gowans, EJ, Papenfuss, Anthony, T., Miles, J., Freeman, J., Giudicelli, V., Burrows, Scott, Gowans, E. J., Gowans, E, Loveland, B, Giudicelli, Veronique, Papenfuss, AT, Miles, J. J., Corbin, Vincent, D. A., Freeman, JD, Li, S., Scheerlinck, Jean-Paul, Lefranc, M. P., Duroux, P, Cameron, Paul, U., Duroux, Patrice, Miles, JJ, Papenfuss, Anthony T., Lefranc, MP, Frohman, Michael A., Miles, John J., Cameron, PU, Plebanski, Magdalena, Scheerlinck, Jean-Pierre, Burrows, S. R., Gowans, Eric, Loveland, B., Alamyar, E., Lefranc, Marie-Paule, Corbin, VDA, Gowans, Eric J., Giudicelli, V, Scheerlinck, JP, Frohman, M. A., Lefranc, M., Burrows, Scott, R., Li, Shuo, Plebanski, M., Cameron, Paul U., Corbin, V. D., Loveland, Bruce, Freeman, John, Cameron, Paul, Frohman, MA, Corbin, V., Frohman, Michael, Plebanski, M, Burrows, S., Cameron, P., Cameron, P. U., Frohman, M., Miles, John, Freeman, J. D., Li, S, Alamyar, E   +74 more
core   +1 more source

Antibody Informatics: IMGT, the International ImMunoGeneTics Information System

Microbiology Spectrum, 2014
ABSTRACTAntibody informatics, a part of immunoinformatics, refers to the concepts, databases, and tools developed and used to explore and to analyze the particular properties of the immunoglobulins (IG) or antibodies, compared with conventional genes and proteins.
openaire   +2 more sources

Standardized IMGT® Nomenclature of Salmonidae IGH Genes, the Paradigm of Atlantic Salmon and Rainbow Trout: From Genomics to Repertoires

Frontiers in Immunology, 2019
In teleost fish as in mammals, humoral adaptive immunity is based on B lymphocytes expressing highly diverse immunoglobulins (IG). During B cell differentiation, IG loci are subjected to genomic rearrangements of V, D, and J genes, producing a unique ...
Susana Magadan, Susana Magadan, Aleksei Krasnov, Saida Hadi-Saljoqi, Sergey Afanasyev, Stanislas Mondot, Delphine Lallias, Rosario Castro, Irene Salinas, Oriol Sunyer, John Hansen, Ben F. Koop, Marie-Paule Lefranc, Pierre Boudinot   +13 more
doaj   +1 more source

IMGT/3Dstructure-DB and IMGT/DomainGapAlign: a database and a tool for immunoglobulins or antibodies, T-cell receptors, MHC, IgSF and MhcSF [PDF]

, 2009
IMGT/3Dstructure-DB is the three-dimensional (3D) structure database of IMGT. ®, the international ImMunoGenetics information system. ® that is acknowledged as the global reference in immunogenetics and immunoinformatics.
Ehrenmann, F., Ehrenmann, François, Kaas, Q., Lefranc, M.-P., Lefranc, Marie-Paule   +4 more
core   +1 more source