Results 71 to 80 of about 8,040 (174)

IMGT® databases, related tools and web resources through three main axes of research and development

, 2022
International audienceIMGT®, the international ImMunoGeneTics information system®, http://www.imgt.org/, is at the forefront of the immunogenetics and immunoinformatics fields with more than 30 years of experience.
Jabado-Michaloud, Joumana, El Hamwi, Amar, Debbagh, Chahrazed, Duroux, Patrice, Kushwaha, Anjana, Viart, Benjamin, Chentli, Imène, Aouinti, Safa, Manso, Taciana, Papadaki, Ariadni, Nguefack Ngoune, Viviane, Bertignac, Morgane, Elazami Elhassani, Merouane, Folch, Géraldine, Hadi-Saljoqi, Saida, Giudicelli, Véronique, Pégorier, Perrine, Albani, Alexandre, Goret, Agathe, Sanou, Gaoussou, Tran, Anna, Georga, Maria, Rollin, Maël, Cherouali, Karima, Kossida, Sofia   +24 more
core   +1 more source

The Novel HLA Class II Alleles DRB1*15:03:06, DQB1*03:01:69 and DPB1*04:01:95 Identified in Brazilian Donors

HLA, Volume 107, Issue 3, March 2026.
ABSTRACT Identification of the novel HLA alleles DRB1*15:03:06, DQB1*03:01:69 and DPB1*04:01:95 in Brazilian individuals.
Augusto Cesar Soares dos Santos Júnior, Cintia Keilla Fabreti de Oliveira, Marcelo Iraja Mion, Lucas Rafael da Silva, Raquel Aparecida Fabreti‐Oliveira   +4 more
wiley   +1 more source

HLAscan: genotyping of the HLA region using next-generation sequencing data

BMC Bioinformatics, 2017
Background Several recent studies showed that next-generation sequencing (NGS)-based human leukocyte antigen (HLA) typing is a feasible and promising technique for variant calling of highly polymorphic regions. To date, however, no method with sufficient
Sojeong Ka, Sunho Lee, Jonghee Hong, Yangrae Cho, Joohon Sung, Han-Na Kim, Hyung-Lae Kim, Jongsun Jung   +7 more
doaj   +1 more source

Integrated scFv identification and CAR T cell generation for AML targeting in vivo

International Journal of Cancer, Volume 158, Issue 4, Page 994-1007, 15 February 2026.
What's new? Acute myeloid leukemia (AML) is a rapidly progressing blood cancer. Advancing chimeric antigen receptor (CAR) T cell therapies, particularly through rapid translation of single chain variable fragment (scFv) discovery into CAR constructs, may improve clinical outcomes, especially the development of patient individualized CAR T cells.
Yi Liu, Annika Lauk, David Sedloev, Josephine Brysting, Ela Cetin, Chunan Liu, Maximilian Mönnig, Thomas Luft, Haiyang Yun, Michael Schmitt, Tim Sauer, Fengbiao Zhou, Christian Rohde, Carsten Müller‐Tidow   +13 more
wiley   +1 more source

Therapeutic monoclonal antibodies repurposing in oncology via IMGT/mAb-KG embeddings

BMC Medical Informatics and Decision Making
Background Cancer remains one of the leading causes of mortality worldwide, accounting for approximately 9.7 million deaths in 2022. Faced with this significant public health challenge, therapeutic monoclonal antibodies (mAbs) have emerged as promising ...
Gaoussou Sanou, Taciana Manso, Konstantin Todorov, Véronique Giudicelli, Patrice Duroux, Sofia Kossida   +5 more
doaj   +1 more source

The evolutionary history of IGKC in mammals reveals ancient duplications and remarkable divergence in lagomorphs

Frontiers in Immunology
BackgroundThe Immunoglobulin Kappa Constant (IGKC) gene encodes the constant region of the immunoglobulin kappa light chain, a crucial component of antibodies.
Ana Pinheiro, Ana Pinheiro, J. Ricardo Borges, J. Ricardo Borges, J. Ricardo Borges, João Pedro Marques, João Pedro Marques, Pedro José Esteves, Pedro José Esteves, Pedro José Esteves, Pedro José Esteves   +10 more
doaj   +1 more source

Analysis of the Repertoire Features of TCR Beta Chain CDR3 in Human by High-Throughput Sequencing

Cellular Physiology and Biochemistry, 2016
Background/Aims: To ward off a wide variety of pathogens, the human adaptive immune system harbors a vast array of T-cell receptors, collectively referred to as the TCR repertoire.
Xianliang Hou, Mingbang Wang, Chong Lu, Qian Xie, Guangying Cui, Jianing Chen, Yu Du, Yong Dai, Hongyan Diao   +8 more
doaj   +1 more source

Invariant γδTCR natural killer-like effector T cells in the naked mole-rat

Nature Communications
The naked mole-rat (Heterocephalus glaber) is a long-lived rodent species showing resistance to the development of cancer. Although naked mole-rats have been reported to lack natural killer (NK) cells, γδ T cell-based immunity has been suggested in this ...
Guillem Sanchez Sanchez, Stephan Emmrich, Maria Georga, Ariadni Papadaki, Sofia Kossida, Andrei Seluanov, Vera Gorbunova, David Vermijlen   +7 more
doaj   +1 more source

IMGT, the international ImMunoGeneTics information system®, http://imgt.cines.fr: the reference in immunoinformatics

, 2003
IMGT, the international ImMunoGeneTics information system® (http://imgt.cines.fr), is a high quality integrated information system specializing in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) and related proteins of the immune system of human and other vertebrates, created in 1989, by the Laboratoire d&
Lefranc, Marie-Paule, Giudicelli, Véronique, Ginestoux, Chantal, Chaume, Denys   +3 more
openaire   +4 more sources

VDJ gene usage among B-cell receptors in ABO-incompatible kidney transplantation determined by RNA-seq Transcriptomic analysis

BMC Nephrology, 2017
Background Studies on B-cell subtypes and V(D)J gene usage of B-cell receptors in kidney transplants are scarce. This study aimed to investigate V(D)J gene segment usage in ABO-incompatible (ABOi) kidney transplant (KT) patients compared to that in ABO ...
Hee Jung Jeon, Kwangsoo Kim, Jae-Ghi Lee, Joon Young Jang, Seongmin Choi, Taishi Fang, Ji-Jing Yan, Miyeun Han, Jong Cheol Jeong, Kyoung-Bun Lee, Tae Jin Kim, Curie Ahn, Jaeseok Yang   +12 more
doaj   +1 more source