Results 51 to 60 of about 8,040 (174)

Profiling the T Cell Receptor Alpha/Delta Locus in Salmonids

Frontiers in Immunology, 2021
In jawed vertebrates, two major T cell populations have been characterized. They are defined as α/β or γ/δ T cells, based on the expressed T cell receptor.
Eva-Stina Edholm, Christopher Graham Fenton, Stanislas Mondot, Stanislas Mondot, Ruth H. Paulssen, Marie-Paule Lefranc, Pierre Boudinot, Susana Magadan, Susana Magadan   +8 more
doaj   +1 more source

The Steroidal Profile Modulates Adaptive Immune Response and Prognosis in Adrenocortical Carcinoma: Analysis of TCR and BCR Repertoires

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Adrenocortical carcinoma (ACC) is a rare and aggressive malignant neoplasm with limited therapeutic options and an often poor prognosis. A deeper understanding of its interaction with the immune system is essential for the advancement of personalized treatment strategies, particularly in light of the tumor heterogeneity of hormone production ...
Jean Silva de Souza Resende, Igor Samesima Giner, João Carlos Degraf Muzzi, José Alexandre Marzagão Barbuto, Enzo Lalli, Mauro Antônio Alves Castro, Bonald Cavalcante de Figueiredo   +6 more
wiley   +1 more source

IMGT-Choreography for immunogenetics and immunoinformatics.

, 2005
International audienceIMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr), was created in 1989 at Montpellier, France. IMGT is a high quality integrated knowledge resource specialized in immunoglobulins (IG), T cell receptors
Combres, Kora, Chaume, Denys, Kaas, Quentin, Duprat, Elodie, Lefranc, Gérard, Ginestoux, Chantal, Chastellan, Patrick, Giudicelli, Véronique, Lefranc, Marie-Paule, Clément, Olivier, Coelho, Isabelle   +10 more
core   +1 more source

IMGT/mAb-KG: the knowledge graph for therapeutic monoclonal antibodies

Frontiers in Immunology
IntroductionTherapeutic monoclonal antibodies (mAbs) have demonstrated promising outcomes in diverse clinical indications, including but not limited to graft rejection, cancer, and autoimmune diseases lately.Recognizing the crucial need for the ...
Gaoussou Sanou, Gaoussou Sanou, Taciana Manso, Konstantin Todorov, Véronique Giudicelli, Patrice Duroux, Sofia Kossida   +6 more
doaj   +1 more source

Inferred Allelic Variants of Immunoglobulin Receptor Genes: A System for Their Evaluation, Documentation, and Naming

Frontiers in Immunology, 2019
Immunoglobulins or antibodies are the main effector molecules of the B-cell lineage and are encoded by hundreds of variable (V), diversity (D), and joining (J) germline genes, which recombine to generate enormous IG diversity.
Mats Ohlin, Cathrine Scheepers, Cathrine Scheepers, Martin Corcoran, William D. Lees, Christian E. Busse, Davide Bagnara, Linnea Thörnqvist, Jean-Philippe Bürckert, Katherine J. L. Jackson, Duncan Ralph, Chaim A. Schramm, Nishanth Marthandan, Felix Breden, Jamie Scott, Frederick A. Matsen IV, Victor Greiff, Gur Yaari, Steven H. Kleinstein, Scott Christley, Jacob S. Sherkow, Sofia Kossida, Marie-Paule Lefranc, Menno C. van Zelm, Corey T. Watson, Andrew M. Collins   +25 more
doaj   +1 more source

Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling

eLife, 2021
Use of adaptive immune receptor repertoire sequencing (AIRR-seq) has become widespread, providing new insights into the immune system with potential broad clinical and diagnostic applications.
Johannes Trück, Anne Eugster, Pierre Barennes, Christopher M Tipton, Eline T Luning Prak, Davide Bagnara, Cinque Soto, Jacob S Sherkow, Aimee S Payne, Marie-Paule Lefranc, Andrew Farmer, The AIRR Community, Magnolia Bostick, Encarnita Mariotti-Ferrandiz   +13 more
doaj   +1 more source

Unraveling IGK locus in dog breeds: IMGT^® new insights into canine immunogenetics. [PDF]

NAR Genom Bioinform
Abstract Over thousands of years, selective breeding of domestic dogs (Canis lupus familiaris) has led to extensive genetic diversity, underscoring the need for refined genomic and immunogenetic investigations. This study presents a comprehensive analysis and biocuration of the immunoglobulin kappa light chain locus (IGK) across ...
Kustro Garnica T, Papadaki A, Georga M, Zeitoun G, Jabado-Michaloud J, Folch G, Giudicelli V, Gonzalez P, Lesbon JCC, Alves TGL, Fukumasu H, Kossida S.   +11 more
europepmc   +4 more sources

IMGT-Choreography for immunogenetics and immunoinformatics.

In silico biology, 2004
IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr), was created in 1989 at Montpellier, France. IMGT is a high quality integrated knowledge resource specialized in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) of human and other vertebrates, and related proteins of the immune system ...
Lefranc, Marie-Paule, Clément, Olivier, Kaas, Quentin, Duprat, Elodie, Chastellan, Patrick, Coelho, Isabelle, Combres, Kora, Ginestoux, Chantal, Giudicelli, Véronique, Chaume, Denys, Lefranc, Gérard   +10 more
openaire   +5 more sources

Deciphering Gorilla gorilla gorilla immunoglobulin loci in multiple genome assemblies and enrichment of IMGT resources

Frontiers in Immunology
Through the analysis of immunoglobulin genes at the IGH, IGK, and IGL loci from four Gorilla gorilla gorilla genome assemblies, IMGT® provides an in-depth overview of these loci and their individual variations in a species closely related to humans.
Chahrazed Debbagh, Géraldine Folch, Joumana Jabado-Michaloud, Véronique Giudicelli, Sofia Kossida, Sofia Kossida   +5 more
doaj   +1 more source

Cold Agglutinin Disease–Like Genetic Signatures in Lymphoplasmacytic Lymphoma–Like Cases Challenge the WHO Fifth Edition Classification

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Background The fifth edition of the World Health Organization (WHO) classification defines cold agglutinin disease (CAD) as a clonal B‐cell lymphoproliferative disorder occurring in the absence of overt lymphoma, whereas cases associated with lymphoma are classified as cold agglutinin syndrome (CAS).
Yuki Sato, Daisuke Koyama, Shoki Yamada, Kengo Suzuki, Masahiko Fukatsu, Yuka Oka, Yuko Hashimoto, Takayuki Ikezoe   +7 more
wiley   +1 more source