Results 1 to 10 of about 29,648 (219)

Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP

Nature Communications, 2022
The translation of mechanical cues into gene expression changes is dependent on the nuclear import of mechanoresponsive transcriptional regulators. Here the authors identify that Importin-7 drives the nuclear import of one such regulator YAP while YAP ...
María García-García, Sheung Chun Ng, Sergio Casas Tintó   +2 more
exaly   +2 more sources

Ran modulates allosteric crosstalk between importin β surfaces [PDF]

Nature Communications
A cellular gradient of the GTPase Ran orchestrates the movement of import and export complexes through the Nuclear Pore Complex (NPC). Ran-GTP modulates two essential activities of importin β during nuclear import. On the one hand, it reduces the avidity
Ying-Hui Ko, Fenglin Li, Stephanie S. Suinn, Junwei Li, Chun-Feng David Hou, Ravi K. Lokareddy, Gino Cingolani   +6 more
doaj   +2 more sources

Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1

Nature Communications, 2017
Importin α3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. Here the authors reveal the molecular basis for the selectivity of RCC1 for importin α3 vs the generic importin α1 and discuss the evolution of importin α ...
Ravi K Lokareddy, Ruth A Pumroy, Richard E Gillilan   +2 more
exaly   +2 more sources

Ligands binding diffusively to protein target act as inhibitors of protein-protein interactions. [PDF]

PLoS Computational Biology
Nuclear localization signal (NLS) sequence from capsid protein of Venezuelan equine encephalitis virus (VEEV) binds to importin-α transport protein and clogs nuclear import. Prevention of viral NLS binding to importin-α may represent a viable therapeutic
William Jeffries, Bryan M Delfing, Xavier E Laracuente, Xingyu Luo, Audrey Olson, Kenneth W Foreman, Kyung Hyeon Lee, Greg Petruncio, Vito De Benedictis, Mikell Paige, Kylene Kehn-Hall, Christopher Lockhart, Dmitri K Klimov   +12 more
doaj   +2 more sources

Ibetazol, a novel inhibitor of importin β1-mediated nuclear import [PDF]

Communications Biology
Nucleocytoplasmatic transport plays an essential role in eukaryotic cell homeostasis and is mediated by karyopherins. Importin β1 (KPNB1) and its adaptor protein importin α1 (KPNA2) are the best-characterized karyopherins that effect nuclear import. Here,
Thomas Vercruysse, Els Vanstreels, Maarten Jacquemyn, Sandro Boland, Amuri Kilonda, Sara Allasia, Ilse Vandecaetsbeek, Hugo Klaassen, Matthias Versele, Patrick Chaltin, Arnaud Marchand, Dirk Daelemans   +11 more
doaj   +2 more sources

Structural characterization of human importin alpha 7 in its cargo-free form at 2.5 Å resolution

Scientific Reports, 2022
Shuttling of macromolecules between nucleus and cytoplasm is a tightly regulated process mediated through specific interactions between cargo and nuclear transport proteins.
S. Tsimbalyuk, C. M. Donnelly, J. K. Forwood   +2 more
doaj   +1 more source

Identification of Novel Stress Granule Components That Are Involved in Nuclear Transport. [PDF]

PLoS ONE, 2013
BACKGROUND:Importin-α1 belongs to a subfamily of nuclear transport adaptors and participates in diverse cellular functions. Best understood for its role in protein transport, importin-α1 also contributes to other biological processes.
Hicham Mahboubi, Evangeline Seganathy, Dekun Kong, Ursula Stochaj   +3 more
doaj   +1 more source

Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection

Cell Reports, 2020
Summary: Importin-α adaptor proteins orchestrate dynamic nuclear transport processes involved in cellular homeostasis. Here, we show that importin-α3, one of the main NF-κB transporters, is the most abundantly expressed classical nuclear transport factor
Swantje Thiele, Stephanie Stanelle-Bertram, Sebastian Beck, Nancy Mounogou Kouassi, Martin Zickler, Martin Müller, Berfin Tuku, Patricia Resa-Infante, Debby van Riel, Malik Alawi, Thomas Günther, Franziska Rother, Stefanie Hügel, Susanne Reimering, Alice McHardy, Adam Grundhoff, Wolfram Brune, Albert Osterhaus, Michael Bader, Enno Hartmann, Gülsah Gabriel   +20 more
doaj   +1 more source

Drosophila Importin-α2 is involved in synapse, axon and muscle development. [PDF]

PLoS ONE, 2010
Nuclear import is required for communication between the cytoplasm and the nucleus and to enact lasting changes in gene transcription following stimuli.
Timothy J Mosca, Thomas L Schwarz
doaj   +1 more source

A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALS

Neurobiology of Disease, 2021
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons. Mislocalization of TAR DNA-binding protein 43 (TDP-43) is an early event in the formation of cytoplasmic TDP-43-positive inclusions ...
Yu-Ju Liu, Hung-Chih Kuo, Yijuang Chern
doaj   +1 more source