Results 101 to 110 of about 29,648 (219)
RAM function is dependent on Kapβ2-mediated nuclear entry [PDF]
, 2014 Eukaryotic gene expression is dependent on the modification of the first transcribed nucleotide of pre-mRNA by the addition of the 7-methylguanosine cap.
Aregger +24 more
core +4 more sources
Viruses Challenge Selectivity Barrier of Nuclear Pores
Viruses, 2013 Exchange between the nucleus and the cytoplasm occurs through nuclear pore complexes (NPCs) embedded in the double membrane of the nuclear envelope. NPC permeability barrier restricts the entry of inert molecules larger than 5 nm in diameter but allows ...
Ariberto Fassati, Aksana A. Labokha
doaj +1 more source
Developmental regulation of the heat shock response by nuclear transport factor karyopherin-α3 [PDF]
, 2001 During early stages of Drosophila development the heat-shock response cannot be induced. It is reasoned that the adverse effects on cell cycle and cell growth brought about by Hsp70 induction must outweigh the beneficial aspects of Hsp70 induction in the
Chen, Tianxin +3 more
core
Analysis of the effects of importin α1 on the nuclear translocation of IL-1α in HeLa cells
Scientific ReportsInterleukin-1α (IL-1α), a cytokine released by necrotic cells, causes sterile inflammation. On the other hand, IL-1α is present in the nucleus and also regulates the expression of many proteins.
Akiko Yamada +5 more
doaj +1 more source
Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex [PDF]
, 2016 Nuclear Pore Complexes (NPCs) are key cellular transporter that control nucleocytoplasmic transport in eukaryotic cells, but its transport mechanism is still not understood.
Coalson, Rob D. +7 more
core +1 more source
Biobanking efforts and new advances in male fertility preservation for rare and endangered species
Asian Journal of Andrology, 2015 Understanding and sustaining biodiversity is a multi-disciplinary science that benefits highly from the creation of organized and accessible collections of biomaterials (Genome Resource Banks).
Pierre Comizzoli
doaj +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun +16 more
wiley +1 more source
Advanced Science, Volume 13, Issue 3, 14 January 2026.Lactylation, linked to glycolysis, is poorly understood in regulation. It is found that LDHA is lactylated at Lys81/Lys318 by AARS1, boosting its activity and cellular lactylation via positive feedback in LUAD. Lactylation regulates NHEJ‐related proteins; their delactylation impairs NHEJ and increases cisplatin sensitivity, offering anticancer insights.
Jizhuo Li +11 more
wiley +1 more source
RNA interference approaches for treatment of HIV-1 infection. [PDF]
, 2015 HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L +2 more
core +1 more source
Advanced Science, Volume 13, Issue 5, 27 January 2026.Glutathione (GSH) defines oxidative balance, but can it directly tune central metabolism? The research reveals that GSH binds and potently activates pyruvate kniase M2 (PKM2), rewiring glycolysis and dictating ferroptosis sensitivity. Combining GSH depletion with PKM2 activation triggers mitochondrial damage and lipid peroxidation, profoundly ...
Tsan‐Jan Chen +17 more
wiley +1 more source