Results 21 to 30 of about 29,648 (219)

Importin α transports CaMKIV to the nucleus without utilizing importin β [PDF]

The EMBO Journal, 2005
Ca(2+)/calmodulin-dependent protein kinase type IV (CaMKIV) plays an essential role in the transcriptional activation of cAMP response element-binding protein-mediated signaling pathways. Although CaMKIV is localized predominantly in the nucleus, the molecular mechanism of the nuclear import of CaMKIV has not been elucidated.
Ippei, Kotera, Toshihiro, Sekimoto, Yoichi, Miyamoto, Takuya, Saiwaki, Emi, Nagoshi, Hiroyuki, Sakagami, Hisatake, Kondo, Yoshihiro, Yoneda   +7 more
openaire   +2 more sources

Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]

, 2017
Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela, DE SANTIS, RICCARDO, DE TURRIS, VALERIA, GILISTRO, EUGENIA, Lavia, Patrizia, MORONI, SARA, ROSA, ALESSANDRO, VERRICO, ANNALISA   +7 more
core   +1 more source

Data on dimer formation between importin α subtypes

Data in Brief, 2016
This article describes data related to the research article titled “Functional characterization of importin α8 as a classical nuclear localization signal receptor” [1].
Yoichi Miyamoto, Masahiro Oka
doaj   +1 more source

Probing formation of cargo/importin-α transport complexes in plant cells using a pathogen effector [PDF]

, 2014
Importin-αs are essential adapter proteins that recruit cytoplasmic proteins destined for active nuclear import to the nuclear transport machinery. Cargo proteins interact with the importin-α armadillo repeat domain via nuclear localization sequences ...
Asai, Shuta, Banfield, Mark J., Caillaud, Marie-Cécile, Fabro, Georgina, Jones, Alexandra M. E., Jones, Jonathan D. G., Rallapalli, Ghanasyam, Roth, Charlotte, Sklenar, Jan, Wiermer, Marcel, Wirthmueller, Lennart   +10 more
core   +2 more sources

UV-induced nuclear import of XPA is mediated by importin-α4 in an ATR-dependent manner. [PDF]

PLoS ONE, 2013
Xeroderma pigmentosum Group A (XPA) is a crucial factor in mammalian nucleotide excision repair (NER) and nuclear import of XPA from the cytoplasm for NER is regulated in cellular DNA damage responses in S-phase.
Zhengke Li, Phillip R Musich, Brian M Cartwright, Hui Wang, Yue Zou   +4 more
doaj   +1 more source

The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus [PDF]

, 2010
Expansion of a polyglutamine (polyQ) tract in the Huntingtin (Htt) protein causes Huntington's disease (HD), a fatal inherited neurodegenerative disorder.
Baquet, Bates, Bennett, Bhakar, Blahos, Caviston, Chen, Cho, Colin, Colomer, Dragatsis, Dunkley, Edoardo Marcora, Engelender, Fagerlund, Fridmacher, Gauthier, Graham, Gray, Gutekunst, Hanz, Harkiolaki, Hayden, Hering, Hickey, Hunt, Imarisio, Jordan, Joshi, Kaltschmidt, Kaltschmidt, Kaltschmidt, Kennedy, Korkin, Kornau, Leavitt, Leavitt, Li, Li, Li, Lipsky, Ma, Marcora, Marini, Marini, Mary B. Kennedy, Mattson, Meffert, Meffert, Menalled, Mikenberg, Mosammaparast, Otis, Patterson, Perlson, Shimojo, Simmons, Song, Strand, Sun, Suzuki, Takano, The Huntington's Disease Collaborative Research Group, Thompson, Tian, Towbin, Trushina, Velier, Wang, Wellmann, Xie, Zhang, Zuccato, Zuccato, Zuccato   +74 more
core   +4 more sources

Phosphorylation of importin-α1 by CDK1-cyclin B1 controls mitotic spindle assembly [PDF]

, 2019
Importin-α serves as an adaptor linking importin-β to proteins carrying a nuclear localization sequence (NLS). During interphase, this interaction enables nuclear protein import, while in mitosis it regulates spindle assembly factors (SAFs) and controls ...
Alfonso-Pérez, Askjaer, Bamba, Bentley, Bian, Bischoff, Bischoff, Caudron, Chen, Ciciarello, Cingolani, Clarke, Conti, Conti, Fu, Fu, Garrett, Giesecke, Gilistro, Gruss, Gruss, Heald, Hornbeck, Hutchins, Johnson, Kaláb, Kaláb, Kinoshita, Kobe, Kufer, Li, Lu, Mayer, Moore, Mountain, Musacchio, Nachury, Nigg, Petry, Pumroy, Sankhala, Schatz, Silljé, Swaminathan, Trieselmann, Whitfield, Wiese, Wittmann, Wu, Zhu   +49 more
core   +2 more sources

Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha. [PDF]

PLoS ONE, 2017
The GW182/TNRC6 family of proteins are central scaffolds that link microRNA-associated Argonaute proteins to the cytoplasmic decay machinery for targeted mRNA degradation processes.
Jessica J Chaston, Alastair Gordon Stewart, Mary Christie   +2 more
doaj   +1 more source

Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential [PDF]

, 2016
The Karyopherin superfamily is a major class of soluble transport receptors consisting of both import and export proteins. The trafficking of proteins involved in transcription, cell signalling and cell cycle regulation among other functions across the ...
Aggarwal, Albee, Alnabulsi, Alshareeda, Altan, Angus, Behrens, Bernis, Blower, Brinkmann, Brinkmann, Cansizoglu, Chang, Christiansen, Dahl, Das, Dasso, Depping, Dikovskaya, Forbes, Gluz, Gontan, Gorlich, Gousias, Gousias, Gousias, Grupp, Gruss, Hashimoto, Hintersteiner, Hu, Huang, Huang, Huang, Hutchins, Hügel, Ishizawa, Jensen, Jiang, Kahle, Kau, Kazim, Kim, Kimura, King, Knauer, Kojima, Kosugi, Kudo, Kurisaki, Kutay, Kuusisto, Kuusisto, Lapalombella, Latvia, Lau, Laurila, Li, Liang, Liao, Lin, Lin, Lorenzato, Ma, Marfori, Martens-de Kemp, Melo, Mortezavi, Mosammaparast, Muller, Nevins, Noske, Parikh, Poon, Pumroy, Quan, Quensel, Rensen, Sakai, Scherf, Shen, Shi, Shiraki, Sillje, Smith, Smith, Soderholm, Song, Stawerski, Stella Tsai, Stewart, Tai, Torgerson, Turner, Turner, Wagstaff, Wang, Wang, Wang, Watt, Watt, Watt, Wellmann, Wiese, Winkler, Winnepenninckx, Wu, Yan, Yang, Yao, Yoshitake, Yu, Zender, Zheng, Zhou, Zhu, Zhu, Zienkiewicz   +117 more
core   +1 more source

Karyopherin α7 (KPNA7), a divergent member of the importin α family of nuclear import receptors

BMC Cell Biology, 2010
Background Classical nuclear localization signal (NLS) dependent nuclear import is carried out by a heterodimer of importin α and importin β. NLS cargo is recognized by importin α, which is bound by importin β.
Kelley Joshua B, Talley Ashley M, Spencer Adam, Gioeli Daniel, Paschal Bryce M   +4 more
doaj   +1 more source