Production of Indole-3-Lactic Acid by Bifidobacterium Strains Isolated fromHuman Infants [PDF]
Microorganisms, 2019 Recent studies have shown that metabolites produced by microbes can be considered as mediators of host-microbial interactions. In this study, we examined the production of tryptophan metabolites by Bifidobacterium strains found in the gastrointestinal ...
Takuma Sakurai +2 more
doaj +2 more sources
Phosphoserine phosphatase B facilitates indole metabolism to indole-3-lactic acid [PDF]
Applied Microbiology and BiotechnologyIntestinal bacteria can convert indole to a range of compounds; however, the precise enzymatic processes facilitating this conversion have not been fully elucidated.
Hiroaki Konishi +5 more
doaj +2 more sources
Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming [PDF]
Gut MicrobesResearch indicates that abnormal gut microbiota metabolism is linked to colorectal cancer (CRC) progression, but the role of microbiota-related tryptophan metabolism disruption remains unclear.
Shizhen Zhou +11 more
doaj +2 more sources
Lactobacillus gasseri LGV03-derived indole-3-lactic acid ameliorates immune response by activating aryl hydrocarbon receptor [PDF]
Microbial Cell FactoriesPrevious studies showed that the female genital tract microbiome plays a crucial role in regulating the host’s immune defense mechanisms. Our previous research has shown that Lactobacillus gasseri LGV03 (L.
Zikang Zhang +6 more
doaj +2 more sources
Bacillus megaterium GXU087 secretes indole - 3 - lactic acid to promote soybean growth and nodulation [PDF]
Frontiers in Plant ScienceBacillus species are recognized as plant growth-promoting bacteria (PGPB), yet the mechanisms behind their crop growth promotion remain elusive. This study is designed to explore the plant growth-promoting (PGP) effects of Bacillus megaterium GXU087 on ...
Jingsi Qiu +6 more
doaj +2 more sources
Human gut-associated Bifidobacterium species salvage exogenous indole, a uremic toxin precursor, to synthesize indole-3-lactic acid via tryptophan [PDF]
Gut MicrobesIndole in the gut is formed from dietary tryptophan by a bacterial tryptophan-indole lyase. Indole not only triggers biofilm formation and antibiotic resistance in gut microbes but also contributes to the progression of kidney dysfunction after ...
Cheng Chung Yong +12 more
doaj +2 more sources
The impact of indole-3-lactic acid on immature intestinal innate immunity and development: a transcriptomic analysis [PDF]
Scientific Reports, 2021 An excessive intestinal inflammatory response may have a role in the pathogenesis of necrotizing enterocolitis (NEC) in very preterm infants. Indole-3-lactic acid (ILA) of breastmilk tryptophan was identified as the anti-inflammatory metabolite involved ...
Wuyang Huang +3 more
doaj +2 more sources
The Effect of Indole-3-Lactic Acid from Lactiplantibacillus plantarum ZJ316 on Human Intestinal Microbiota In Vitro [PDF]
Foods, 2022 Microbiota-derived tryptophan metabolites are essential signals for maintaining gut homeostasis, yet the potential contribution to modulating gut microbiota has been rarely investigated. In this study, Lactiplantibacillus plantarum ZJ316 (CCTCC No.
Qingqing Zhou +6 more
doaj +2 more sources
Potential Effects of Indole-3-Lactic Acid, a Metabolite of Human Bifidobacteria, on NGF-Induced Neurite Outgrowth in PC12 Cells [PDF]
Microorganisms, 2020 Gut microbiota-derived tryptophan metabolites such as indole derivatives are an integral part of host metabolome that could mediate gut−brain communication and contribute to host homeostasis.
Chyn Boon Wong +3 more
doaj +2 more sources
Bifidobacteria with indole-3-lactic acid-producing capacity exhibit psychobiotic potential via reducing neuroinflammation [PDF]
Cell Reports MedicineSummary: The escalating global prevalence of depression demands effective therapeutic strategies, with psychobiotics emerging as a promising solution. However, the molecular mechanisms governing the neurobehavioral impact of psychobiotics remain elusive.
Xin Qian +8 more
doaj +2 more sources