Results 1 to 10 of about 16,970 (167)

Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming [PDF]

Gut Microbes
Research indicates that abnormal gut microbiota metabolism is linked to colorectal cancer (CRC) progression, but the role of microbiota-related tryptophan metabolism disruption remains unclear.
Shizhen Zhou, Kai Wang, Jiandong Huang, Zhen Xu, Qinggang Yuan, Lixiang Liu, Zhifeng Wang, Ji Miao, Hao Wang, Tingting Wang, Wenxian Guan, Chao Ding   +11 more
doaj   +5 more sources

Lactobacillus gasseri LGV03-derived indole-3-lactic acid ameliorates immune response by activating aryl hydrocarbon receptor [PDF]

Microbial Cell Factories
Previous studies showed that the female genital tract microbiome plays a crucial role in regulating the host’s immune defense mechanisms. Our previous research has shown that Lactobacillus gasseri LGV03 (L.
Zikang Zhang, Kangdi Zheng, Zhao Zhang, Longbin Cao, Lizhu Lin, Weimin Sun, Feng Qiu   +6 more
doaj   +6 more sources

Production of Indole-3-Lactic Acid by Bifidobacterium Strains Isolated fromHuman Infants [PDF]

Microorganisms, 2019
Recent studies have shown that metabolites produced by microbes can be considered as mediators of host-microbial interactions. In this study, we examined the production of tryptophan metabolites by Bifidobacterium strains found in the gastrointestinal ...
Takuma Sakurai, Toshitaka Odamaki, Jin-zhong Xiao   +2 more
doaj   +7 more sources

Bacillus megaterium GXU087 secretes indole - 3 - lactic acid to promote soybean growth and nodulation [PDF]

Frontiers in Plant Science
Bacillus species are recognized as plant growth-promoting bacteria (PGPB), yet the mechanisms behind their crop growth promotion remain elusive. This study is designed to explore the plant growth-promoting (PGP) effects of Bacillus megaterium GXU087 on ...
Jingsi Qiu, Xiao’ou Meng, Jingdong Li, Tengfei Zhang, Siying Qin, Yuanfu Li, Huihua Tan   +6 more
doaj   +6 more sources

Bifidobacteria with indole-3-lactic acid-producing capacity exhibit psychobiotic potential via reducing neuroinflammation [PDF]

Cell Reports Medicine
Summary: The escalating global prevalence of depression demands effective therapeutic strategies, with psychobiotics emerging as a promising solution. However, the molecular mechanisms governing the neurobehavioral impact of psychobiotics remain elusive.
Xin Qian, Qing Li, Huiyue Zhu, Ying Chen, Guopeng Lin, Hao Zhang, Wei Chen, Gang Wang, Peijun Tian   +8 more
doaj   +5 more sources

The impact of indole-3-lactic acid on immature intestinal innate immunity and development: a transcriptomic analysis [PDF]

Scientific Reports, 2021
An excessive intestinal inflammatory response may have a role in the pathogenesis of necrotizing enterocolitis (NEC) in very preterm infants. Indole-3-lactic acid (ILA) of breastmilk tryptophan was identified as the anti-inflammatory metabolite involved ...
Wuyang Huang, Ky Young Cho, Di Meng, W. Allan Walker   +3 more
doaj   +6 more sources

Potential Effects of Indole-3-Lactic Acid, a Metabolite of Human Bifidobacteria, on NGF-Induced Neurite Outgrowth in PC12 Cells [PDF]

Microorganisms, 2020
Gut microbiota-derived tryptophan metabolites such as indole derivatives are an integral part of host metabolome that could mediate gut−brain communication and contribute to host homeostasis.
Chyn Boon Wong, Azusa Tanaka, Tetsuya Kuhara, Jin-zhong Xiao   +3 more
doaj   +7 more sources

Human gut-associated Bifidobacterium species salvage exogenous indole, a uremic toxin precursor, to synthesize indole-3-lactic acid via tryptophan [PDF]

Gut Microbes
Indole in the gut is formed from dietary tryptophan by a bacterial tryptophan-indole lyase. Indole not only triggers biofilm formation and antibiotic resistance in gut microbes but also contributes to the progression of kidney dysfunction after ...
Cheng Chung Yong, Takuma Sakurai, Hiroki Kaneko, Ayako Horigome, Eri Mitsuyama, Aruto Nakajima, Toshihiko Katoh, Mikiyasu Sakanaka, Takaaki Abe, Jin-Zhong Xiao, Miyuki Tanaka, Toshitaka Odamaki, Takane Katayama   +12 more
doaj   +7 more sources

Pediococcus acidilactici attenuates chronic stress-induced depression via generating metabolite indole-3-lactic acid and downregulating neuroinflammation [PDF]

Journal of Neuroinflammation
Background Depression, a prevalent mental disorder worldwide, is associated with pathological mechanisms including neuroinflammation. Pediococcus acidilactici has shown the potential neuroprotective effects, yet its role in ameliorating depression and ...
Yuhao Wang, Jun Gong, Kexin Geng, Xia Chen, Mengzhen Jia, Cong Yang, Silu Zhang, Jie Pan, Rongrong Wu, Zhigang Liu, Tian Yuan   +10 more
doaj   +5 more sources

Bacteroides uniformis degrades β-glucan to promote Lactobacillus johnsonii improving indole-3-lactic acid levels in alleviating colitis [PDF]

Microbiome
Background Intake of dietary fiber is associated with a reduced risk of inflammatory bowel disease. β-Glucan (BG), a bioactive dietary fiber, has potential health-promoting effects on intestinal functions; however, the underlying mechanism remains ...
Shanshan Zhang, Qixing Nie, Yonggan Sun, Sheng Zuo, Chunhua Chen, Song Li, Jingrui Yang, Jielun Hu, Xingtao Zhou, Yongkang Yu, Ping Huang, Lu Lian, Mingyong Xie, Shaoping Nie   +13 more
doaj   +6 more sources