Results 11 to 20 of about 17,012 (208)

Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2 [PDF]

Journal of Translational Medicine, 2023
Background Lactobacillus has been demonstrated to serve a protective role in intestinal injury. However, the relationship between Lactobacillus murinus (L. murinus)-derived tryptophan metabolites and intestinal ischemia/reperfusion (I/R) injury yet to be
Fang-Ling Zhang, Xiao-Wei Chen, Yi-Fan Wang, Zhen Hu, Wen-Juan Zhang, Bo-Wei Zhou, Peng-Fei Ci, Ke-Xuan Liu   +7 more
doaj   +6 more sources

Bacterial indole-3-lactic acid affects epithelium-macrophage crosstalk to regulate intestinal homeostasis. [PDF]

Proc Natl Acad Sci U S A, 2023
Tryptophan and its derivatives perform a variety of biological functions; however, the role and specific mechanism of many tryptophan derivatives in intestinal inflammation remain largely unclear. Here, we identified that an Escherichia coli strain ( Ec- TMU) isolated from the feces of ...
Yu K, Li Q, Sun X, Peng X, Tang Q, Chu H, Zhou L, Wang B, Zhou Z, Deng X, Yang J, Lv J, Liu R, Miao C, Zhao W, Yao Z, Wang Q.   +16 more
europepmc   +5 more sources

Phosphoserine phosphatase B facilitates indole metabolism to indole-3-lactic acid [PDF]

Applied Microbiology and Biotechnology
Intestinal bacteria can convert indole to a range of compounds; however, the precise enzymatic processes facilitating this conversion have not been fully elucidated.
Hiroaki Konishi, Ryo Matsui, Tomomi Okamura, Asahi Imahase, Tsuneyuki Kobayashi, Hiroyuki Nishiyama   +5 more
doaj   +4 more sources

The Effect of Indole-3-Lactic Acid from Lactiplantibacillus plantarum ZJ316 on Human Intestinal Microbiota In Vitro. [PDF]

Foods, 2022
Microbiota-derived tryptophan metabolites are essential signals for maintaining gut homeostasis, yet the potential contribution to modulating gut microbiota has been rarely investigated. In this study, Lactiplantibacillus plantarum ZJ316 (CCTCC No. M 208077) with a high production (43.14 μg/mL) of indole-3-lactic acid (ILA) was screened. ILA with 99.00%
Zhou Q, Xie Z, Wu D, Liu L, Shi Y, Li P, Gu Q.   +6 more
europepmc   +6 more sources

Lactobacillus-derived indole-3-lactic acid ameliorates colitis in cesarean-born offspring via activation of aryl hydrocarbon receptor. [PDF]

iScience, 2023
Cesarean section (CS) delivery is known to disrupt the transmission of maternal microbiota to offspring, leading to an increased risk of inflammatory bowel disease (IBD). However, the underlying mechanisms remain poorly characterized. Here, we demonstrate that CS birth renders mice susceptible to dextran sulfate sodium (DSS)-induced colitis and impairs
Xia Y, Liu C, Li R, Zheng M, Feng B, Gao J, Long X, Li L, Li S, Zuo X, Li Y.   +10 more
europepmc   +5 more sources

Metabolites of Kimchi Lactic Acid Bacteria, Indole-3-Lactic Acid, Phenyllactic Acid, and Leucic Acid, Inhibit Obesity-Related Inflammation in Human Mesenchymal Stem Cells. [PDF]

J Microbiol Biotechnol, 2023
Given the diversity of vegetables utilized in food fermentation and various lactic acid bacteria (LAB) populations in these materials, comprehensive studies on LAB from vegetable foods, including kimchi, are imperative. Therefore, this study aimed to investigate the obesity-related inflammation response of three metabolites-phenyllactic acid (PLA ...
Lee M, Kim D, Chang JY.
europepmc   +5 more sources

Indole-3-Lactic Acid Attenuates IMQ-Induced Psoriasiform Dermatitis in Mice via AhR-Dependent Suppression of IL-17A [PDF]

Psoriasis: Targets and Therapy
Zhen Meng,1,* Jieru Ren,2,* Yuhsien Lai,3 Siyao Lu,2 Huiyan Wu,2 Yanyun Jiang,2 Zhan Zhang,4 Guozhen Tan,2 Zhenrui Shi2 1Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong, People’s Republic of China ...
Meng Z, Ren J, Lai Y, Lu S, Wu H, Jiang Y, Zhang Z, Tan G, Shi Z   +8 more
doaj   +4 more sources

Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells. [PDF]

BMC Microbiol, 2020
Abstract Background Bifidobacterium longum subsp. infantis (B. infantis) is a commensal bacterium that colonizes the gastrointestinal tract of breast-fed infants. B. infantis can efficiently utilize the abundant supply of oligosaccharides found in human milk (HMO) to help establish residence. We hypothesized that metabolites from B.
Ehrlich AM, Pacheco AR, Henrick BM, Taft D, Xu G, Huda MN, Mishchuk D, Goodson ML, Slupsky C, Barile D, Lebrilla CB, Stephensen CB, Mills DA, Raybould HE.   +13 more
europepmc   +7 more sources

Integrative network pharmacology and machine learning identify potential targets of indole-3-lactic acid in colorectal cancer [PDF]

PLoS ONE
The treatment of colorectal cancer (CRC) remains challenging due to chemotherapy resistance and genetic heterogeneity. Indole-3-lactic acid (ILA), a tryptophan metabolite derived from gut microbiota, exhibits promising anti-inflammatory and anticancer ...
Jie Li, Jian Zhang, Jun Ke, Zhijian Ren, Cuncheng Feng   +4 more
doaj   +4 more sources

Bifidobacterium breve-derived indole-3-lactic acid ameliorates colitis-associated tumorigenesis by directing the differentiation of immature colonic macrophages. [PDF]

Theranostics
Aim: To elucidate dynamics and functions in colonic macrophage subsets, and their regulation by Bifidobacterium breve (B. breve) and its associated metabolites in the initiation of colitis-associated colorectal cancer (CAC). Methods: Azoxymethane (AOM) and dextran sodium sulfate (DSS) were used to create a CAC model.
Li Y, Li Q, Yuan R, Wang Y, Guo C, Wang L.   +5 more
europepmc   +5 more sources