Results 11 to 20 of about 16,665 (202)

Pediococcus acidilactici attenuates chronic stress-induced depression via generating metabolite indole-3-lactic acid and downregulating neuroinflammation [PDF]

Journal of Neuroinflammation
Background Depression, a prevalent mental disorder worldwide, is associated with pathological mechanisms including neuroinflammation. Pediococcus acidilactici has shown the potential neuroprotective effects, yet its role in ameliorating depression and ...
Yuhao Wang, Jun Gong, Kexin Geng, Xia Chen, Mengzhen Jia, Cong Yang, Silu Zhang, Jie Pan, Rongrong Wu, Zhigang Liu, Tian Yuan   +10 more
doaj   +3 more sources

Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2 [PDF]

Journal of Translational Medicine, 2023
Background Lactobacillus has been demonstrated to serve a protective role in intestinal injury. However, the relationship between Lactobacillus murinus (L. murinus)-derived tryptophan metabolites and intestinal ischemia/reperfusion (I/R) injury yet to be
Fang-Ling Zhang, Xiao-Wei Chen, Yi-Fan Wang, Zhen Hu, Wen-Juan Zhang, Bo-Wei Zhou, Peng-Fei Ci, Ke-Xuan Liu   +7 more
doaj   +4 more sources

Bacteroides uniformis degrades β-glucan to promote Lactobacillus johnsonii improving indole-3-lactic acid levels in alleviating colitis [PDF]

Microbiome
Background Intake of dietary fiber is associated with a reduced risk of inflammatory bowel disease. β-Glucan (BG), a bioactive dietary fiber, has potential health-promoting effects on intestinal functions; however, the underlying mechanism remains ...
Shanshan Zhang, Qixing Nie, Yonggan Sun, Sheng Zuo, Chunhua Chen, Song Li, Jingrui Yang, Jielun Hu, Xingtao Zhou, Yongkang Yu, Ping Huang, Lu Lian, Mingyong Xie, Shaoping Nie   +13 more
doaj   +4 more sources

Bacterial indole-3-lactic acid affects epithelium-macrophage crosstalk to regulate intestinal homeostasis. [PDF]

Proc Natl Acad Sci U S A, 2023
Tryptophan and its derivatives perform a variety of biological functions; however, the role and specific mechanism of many tryptophan derivatives in intestinal inflammation remain largely unclear. Here, we identified that an Escherichia coli strain ( Ec- TMU) isolated from the feces of ...
Yu K, Li Q, Sun X, Peng X, Tang Q, Chu H, Zhou L, Wang B, Zhou Z, Deng X, Yang J, Lv J, Liu R, Miao C, Zhao W, Yao Z, Wang Q.   +16 more
europepmc   +3 more sources

Lactobacillus-derived indole-3-lactic acid ameliorates colitis in cesarean-born offspring via activation of aryl hydrocarbon receptor. [PDF]

iScience, 2023
Cesarean section (CS) delivery is known to disrupt the transmission of maternal microbiota to offspring, leading to an increased risk of inflammatory bowel disease (IBD). However, the underlying mechanisms remain poorly characterized. Here, we demonstrate that CS birth renders mice susceptible to dextran sulfate sodium (DSS)-induced colitis and impairs
Xia Y, Liu C, Li R, Zheng M, Feng B, Gao J, Long X, Li L, Li S, Zuo X, Li Y.   +10 more
europepmc   +3 more sources

Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells. [PDF]

BMC Microbiol, 2020
Abstract Background Bifidobacterium longum subsp. infantis (B. infantis) is a commensal bacterium that colonizes the gastrointestinal tract of breast-fed infants. B. infantis can efficiently utilize the abundant supply of oligosaccharides found in human milk (HMO) to help establish residence. We hypothesized that metabolites from B.
Ehrlich AM, Pacheco AR, Henrick BM, Taft D, Xu G, Huda MN, Mishchuk D, Goodson ML, Slupsky C, Barile D, Lebrilla CB, Stephensen CB, Mills DA, Raybould HE.   +13 more
europepmc   +6 more sources

Indole-3-Lactic Acid Inhibits Doxorubicin-Induced Ferroptosis Through Activating Aryl Hydrocarbon Receptor/Nrf2 Signalling Pathway. [PDF]

J Cell Mol Med
ABSTRACTThe clinical application of doxorubicin (DOX) is limited due to its cardiotoxicity, which is primarily attributed to its interaction with iron in mitochondria, leading to lipid peroxidation and myocardial ferroptosis. This study aimed to investigate the role of the gut microbiota‐derived metabolite, indole‐3‐lactic acid (ILA), in mitigating DOX‐
Lian J, Lin H, Lin H, Zhong Z, Song Y, Shao X, Zhou J, Xu L, Sun Z, Yang Y, Chi J, Wang P, Meng L.   +12 more
europepmc   +3 more sources

Effects of Indole-3-Lactic Acid, a Metabolite of Tryptophan, on IL-4 and IL-13-Induced Human Skin-Equivalent Atopic Dermatitis Models. [PDF]

Int J Mol Sci, 2022
Indole-3-lactic acid (I3LA) is a well-known metabolite involved in tryptophan metabolism. Indole derivatives are involved in the differentiation of immune cells and the synthesis of cytokines via the aryl hydrocarbon receptors for modulating immunity, and the indole derivatives may be involved in allergic responses.
Kim K, Kim H, Sung GY.
europepmc   +3 more sources

Uncovering the specificity and predictability of tryptophan metabolism in lactic acid bacteria with genomics and metabolomics

Frontiers in Cellular and Infection Microbiology, 2023
Tryptophan is metabolized by microorganisms into various indole derivatives that have been proven to alleviate diseases and promote human health. Lactic acid bacteria (LAB) are a broad microbial concept, some of which have been developed as probiotics ...
Tong Pan, Tong Pan, Zhangming Pei, Zhangming Pei, Zhifeng Fang, Hongchao Wang, Hongchao Wang, Jinlin Zhu, Jinlin Zhu, Hao Zhang, Hao Zhang, Hao Zhang, Hao Zhang, Jianxin Zhao, Jianxin Zhao, Jianxin Zhao, Wei Chen, Wei Chen, Wei Chen, Wenwei Lu, Wenwei Lu, Wenwei Lu, Wenwei Lu, Wenwei Lu   +23 more
doaj   +1 more source

Metabolites of Kimchi Lactic Acid Bacteria, Indole-3-Lactic Acid, Phenyllactic Acid, and Leucic Acid, Inhibit Obesity-Related Inflammation in Human Mesenchymal Stem Cells. [PDF]

J Microbiol Biotechnol, 2023
Given the diversity of vegetables utilized in food fermentation and various lactic acid bacteria (LAB) populations in these materials, comprehensive studies on LAB from vegetable foods, including kimchi, are imperative. Therefore, this study aimed to investigate the obesity-related inflammation response of three metabolites-phenyllactic acid (PLA ...
Lee M, Kim D, Chang JY.
europepmc   +3 more sources