Results 51 to 60 of about 90,432 (374)
NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease. [PDF]
, 2017 Inflammasomes are cytosolic multiprotein complexes that initiate protective immunity in response to infection, and can also drive auto-inflammatory diseases, but the cell types and signalling pathways that cause these diseases remain poorly understood ...
Nichols, Randilea D +2 more
core +2 more sources
NLRP2 controls age-associated maternal fertility [PDF]
, 2016 Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are well-known for their key roles in the immune system. Ectopically expressed NLRP2 in immortalized cell lines assembles an inflammasome and inhibits activation of the proinflammatory ...
Agostini +24 more
core +2 more sources
Activation and Pharmacological Regulation of Inflammasomes
Biomolecules, 2022 Inflammasomes are intracellular signaling complexes of the innate immune system, which is part of the response to exogenous pathogens or physiological aberration.
Chen Chen, Pinglong Xu
semanticscholar +1 more source
Autophagy in Microglia and Alzheimer's disease [PDF]
, 2019 Alzheimer’s disease (AD) is the most common neurodegenerative disease, characterized by amyloid-beta plaques, neurofibrillary tangles and neuroinflammation. Autophagy has been associated with several neurodegenerative diseases.
Houtman, Judith
core +1 more source
Emerging mechanisms and functions of inflammasome complexes in teleost fish
Frontiers in Immunology, 2023 Inflammasomes are multiprotein complexes, which are assembled in response to a diverse range of exogenous pathogens and endogenous danger signals, leading to produce pro-inflammatory cytokines and induce pyroptotic cell death.
Ming Xian Chang +2 more
doaj +1 more source
Inflammasomes in Cancer Progression and Anti-Tumor Immunity
Frontiers in Cell and Developmental Biology, 2022 The inflammasomes are critical regulators of innate immunity, inflammation and cell death and have emerged as important regulators of cancer development and control. Inflammasomes are assembled by pattern recognition receptors (PRR) following the sensing
Sebastián Lillo, M. Saleh
semanticscholar +1 more source
Kidney surveillance in the spotlight: contrast-induced acute kidney injury illuminated [PDF]
, 2018 Acute kidney injury comprises a heterogeneous group of conditions characterized by a sudden decrease in renal function over hours to days. Contrast-induced acute kidney injury (CI-AKI) is caused by radiographic contrast agents used in diagnostic imaging.
Atkinson, Simon J.
core +1 more source
Frontiers in Cellular Neuroscience, 2022 Recombinant human erythropoietin (rhEPO) has been shown to exert anti-apoptotic and anti-inflammatory effects after cerebral ischemia. Inflammatory cytokines interleukin-1β and -18 (IL-1β and IL-18) are crucial mediators of apoptosis and are maturated by
Eren Arik +11 more
doaj +1 more source
Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases
Journal of Inflammation Research, 2021 Wei Wang, Ni Yang, Yu-Hang Yang, Ri Wen, Chun-Feng Liu, Tie-Ning Zhang Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of ChinaCorrespondence: Chun-Feng Liu; Tie-Ning ZhangDepartment of Pediatrics ...
Wang W +5 more
doaj
The AIM2 inflammasome is activated in astrocytes during the late phase of EAE
JCI Insight, 2022 Inflammasomes are a class of innate immune signaling platforms that activate in response to an array of cellular damage and pathogens. Inflammasomes promote inflammation under many circumstances to enhance immunity against pathogens and inflammatory ...
William E. Barclay +8 more
doaj +1 more source