Results 1 to 10 of about 154,668 (248)
Acid ceramidase regulates innate immune memory. [PDF]
Cell Rep, 2023 Innate immune memory, also called "trained immunity," is a functional state of myeloid cells enabling enhanced immune responses. This phenomenon is important for host defense, but also plays a role in various immune-mediated conditions. We show that exogenously administered sphingolipids and inhibition of sphingolipid metabolizing enzymes modulate ...
Rother N +24 more
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Transcriptome features of innate immune memory in Drosophila. [PDF]
PLoS Genet, 2022 Immune memory is the ability of organisms to elicit potentiated immune responses at secondary infection. Current studies have revealed that similar to adaptive immunity, innate immunity exhibits memory characteristics (called "innate immune memory").
Fuse N +5 more
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Innate Immune Memory in Macrophages. [PDF]
Newborn (Clarksville), 2023 Macrophages have been recognized as the primary mediators of innate immunity starting from embryonic/fetal development. Macrophage-mediated defenses may not be as antigen-specific as adaptive immunity, but increasing information suggests that these responses do strengthen with repeated immunological triggers. The concept of innate memory in macrophages
Maheshwari A.
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Innate immune memory in inflammatory arthritis. [PDF]
Nat Rev Rheumatol, 2023 The concept of immunological memory was demonstrated in antiquity when protection against re-exposure to pathogens was observed during the plague of Athens. Immunological memory has been linked with the adaptive features of T and B cells; however, in the past decade, evidence has demonstrated that innate immune cells can exhibit memory, a phenomenon ...
Jeljeli MM, Adamopoulos IE.
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Genetic dissection of innate immune memory in Drosophila melanogaster. [PDF]
Front Immunol, 2022 Current studies have demonstrated that innate immunity possesses memory characteristics. Although the molecular mechanisms underlying innate immune memory have been addressed by numerous studies, genetic variations in innate immune memory and the ...
Tang C, Kurata S, Fuse N.
europepmc +2 more sources
Modelling Microglial Innate Immune Memory In Vitro: Understanding the Role of Aerobic Glycolysis in Innate Immune Memory. [PDF]
Int J Mol Sci, 2023 Microglia, the resident macrophages of the central nervous system, play important roles in maintaining brain homeostasis and facilitating the brain’s innate immune responses. Following immune challenges microglia also retain immune memories, which can alter responses to secondary inflammatory challenges.
Towriss M, MacVicar B, Ciernia AV.
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Drosophila melanogaster as a model to study innate immune memory. [PDF]
Front Microbiol, 2022 Over the last decades, research regarding innate immune responses has gained increasing importance. A growing body of evidence supports the notion that the innate arm of the immune system could show memory traits.
Arch M +4 more
europepmc +2 more sources
Control of nutrient uptake by IRF4 orchestrates innate immune memory. [PDF]
Nat Immunol, 2023 Santosa EK +10 more
europepmc +1 more source
A new frontier for fat: dietary palmitic acid induces innate immune memory. [PDF]
Immunometabolism (Cobham), 2023 Seufert AL, Napier BA.
europepmc +1 more source
Modulation of Innate Immune Memory Dynamics by Subcellular Reactive Oxygen Species. [PDF]
Antioxid Redox Signal, 2023 Geng S, Lin R, Wu Y, Wang J, Li L.
europepmc +1 more source