C1q reprograms innate immune memory. [PDF]
Front ImmunolInnate immune memory, also called trained immunity, is a metabolic and epigenetically regulated process that enables innate immune cells to recalibrate their inflammatory reactivity in response to pathogenic or endogenous stimuli. In addition to its function in host defense, trained immunity contributes to diverse immune-mediated diseases.
Jonkman I +16 more
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Innate immune memory in macrophage differentiation and cardiovascular diseases. [PDF]
Inflamm RegenInnate immune memory (trained immunity) refers to the ability of innate immune cells, such as monocytes and macrophages, to retain a long-term imprint of a prior stimulus through epigenetic and metabolic adaptations, enabling amplified responses upon ...
Nakayama Y, Fujiu K.
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Development of innate immune memory by non-immune cells during Staphylococcus aureus infection depends on reactive oxygen species. [PDF]
Front Immunol, 2023 IntroductionThe mechanisms underlying innate immune memory (trained immunity) comprise epigenetic reprogramming of transcriptional pathways associated with alterations of intracellular metabolism.
Chaumond E +8 more
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Hypoxia inducible factor-1α regulates microglial innate immune memory and the pathology of Parkinson's disease. [PDF]
J NeuroinflammationNeuroinflammation is one of the core pathological features of Parkinson’s disease (PD). Innate immune cells play a crucial role in the progression of PD.
Dong H +14 more
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Innate immune memory, trained immunity and nomenclature clarification [PDF]
Nature Immunology, 2023 Contains fulltext : 295907.pdf (Publisher’s version ) (Open Access)
George Hajishengallis +2 more
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Redox-signaling in innate immune memory: Similar mechanisms in animals/humans and plants. [PDF]
Redox BiolPlants and animals/humans have evolved sophisticated innate immune systems to cope with microbial attack. Innate immunity implies the presence of membrane-located and intracellular receptors to recognize compounds released by damage or by invading ...
Lindermayr C, Yildirim AÖ.
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Innate immune memory in cardiometabolic disease. [PDF]
Cardiovasc Res, 2023 Abstract Low-grade systemic inflammation is a key pathophysiological component of atherosclerotic cardiovascular disease (CVD), and long-term activation of myeloid cells is thought to be crucial for these effects. Obesity and associated metabolic complications including hyperglycaemia and dyslipoproteinaemia can induce long-lasting ...
Bahrar H +4 more
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The Role of Cell Metabolism in Innate Immune Memory. [PDF]
J Innate Immun, 2022 Immunological memory is classically attributed to adaptive immune responses, but recent studies have shown that challenged innate immune cells can display long-term functional changes that increase nonspecific responsiveness to subsequent infections ...
Ferreira AV +2 more
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Advances in innate immune memory of macrophages
Exploration of Immunology, 2022 Immunity is usually classified into two categories: innate immunity and adaptive immunity, distinguished by the process and characteristics of the immunological impact. It was widely assumed that only adaptive immunity possessed memory features; however,
Safir Ullah Khan, Munir Ullah Khan
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In Vivo Zymosan Treatment Induces IL15-Secreting Macrophages and KLRG1-Expressing NK Cells in Mice
Molecules, 2023 Beta-glucan (β-glucan) is a natural polysaccharide produced by fungi, bacteria, and plants. Although it has been reported that β-glucan enhances innate immune memory responses, it is unclear whether different types of β-glucans display similar immune ...
Hyun Jung Park +7 more
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