Results 21 to 30 of about 154,668 (248)
Immunological Memory in Innate Immunity [PDF]
Journal of Innate Immunity, 2013 ‘trained immunity’. Trained immunity provides protection against reinfection in a T-/B-cell-independent manner, with nonspecific potentiation of inflammatory reactions and antimicrobial mechanisms playing a central role in these effects [4] . The current issue of the Journal of Innate Immunity presents a series of studies that shed additional light on ...
Netea, M.G., Netea, M.G.
openaire +4 more sources
DAMPs and Innate Immune Training
Frontiers in Immunology, 2021 The ability to remember a previous encounter with pathogens was long thought to be a key feature of the adaptive immune system enabling the host to mount a faster, more specific and more effective immune response upon the reencounter, reducing the ...
Elisa Jentho +3 more
doaj +1 more source
Innate Immune Memory in Monocytes and Macrophages: The Potential Therapeutic Strategies for Atherosclerosis. [PDF]
Cells, 2022 Atherosclerosis is a complex metabolic disease characterized by the dysfunction of lipid metabolism and chronic inflammation in the intimal space of the vessel. As the most abundant innate immune cells, monocyte-derived macrophages play a pivotal role in
Guo Z, Wang L, Liu H, Xie Y.
europepmc +2 more sources
hUCMSCs Mitigate LPS-Induced Trained Immunity in Ischemic Stroke
Frontiers in Immunology, 2020 Innate immune memory is a part of the innate immune system that facilitates the elimination of pathogens. However, it may exacerbate neuropathology. In this study, we found that innate immune memory is detrimental in stroke, because it promotes the acute
Yi-wei Feng +17 more
doaj +1 more source
Cross-Generational Impact of Innate Immune Memory Following Pregnancy Complications. [PDF]
Cells, 2022 Pregnancy complications can have long-term negative effects on the health of the affected mothers and their children. In this review, we highlight the underlying inflammatory etiologies of common pregnancy complications and discuss how aberrant ...
Lodge-Tulloch NA +5 more
europepmc +2 more sources
Innate immune memory: An evolutionary perspective [PDF]
Immunological Reviews, 2018 SummaryOver the last decades, there was increasing evidence for the presence of innate immune memory in living organisms. In this review, we compare the innate immune memory of various organisms with a focus on phylogenetics. We discuss the acquisition and molecular basis of immune memory and we describe the innate immune memory paradigm and its role ...
Benjamin Gourbal +5 more
openaire +4 more sources
Epigenetic regulation of innate immune memory in microglia. [PDF]
J Neuroinflammation, 2022 AbstractMicroglia are the tissue-resident macrophages of the CNS. They originate in the yolk sac, colonize the CNS during embryonic development and form a self-sustaining population with limited turnover. A consequence of their relative slow turnover is that microglia can serve as a long-term memory for inflammatory or neurodegenerative events.
Zhang X +8 more
europepmc +8 more sources
Innate immune memory and its application to artificial immune systems. [PDF]
J Supercomput, 2022 The study of innate immune-based algorithms is an important research domain in Artificial Immune System (AIS), such as Dendritic Cell Algorithm (DCA), Toll-Like Receptor algorithm (TLRA). The parameters in these algorithms usually require either manually pre-defined usually provided by the immunologists, or empirically derived from the training dataset,
Wang D +5 more
europepmc +4 more sources
Adaptation and memory in innate immunity [PDF]
Seminars in Immunology, 2016 Contains fulltext : 172821.pdf (Publisher’s version ) (Open Access)
Netea, M.G. +2 more
openaire +2 more sources
Emerging Concepts in Innate Lymphoid Cells, Memory, and Reproduction
Frontiers in Immunology, 2022 Members of the innate immune system, innate lymphoid cells (ILCs), encompass five major populations (Natural Killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer cells) whose functions include defense against pathogens, surveillance of ...
Rodolfo R. Favaro +4 more
doaj +1 more source