Results 11 to 20 of about 70,433 (242)
Microbial Cell Factories, 2022 Background The methylotrophic budding yeast Pichia pastoris GS115 is a powerful expression system and hundreds of heterologous proteins have been successfully expressed in this strain. Recently, P.
Qiquan Zhang +11 more
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Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?
Plants, 2020 Inositol pyrophosphates (PP-InsPs) are an emerging class of “high-energy” intracellular signaling molecules, containing one or two diphosphate groups attached to an inositol ring, that are connected with phosphate sensing, jasmonate signaling,
Catherine Freed +2 more
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Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants?
Molecules, 2020 The ability of an organism to maintain homeostasis in changing conditions is crucial for growth and survival. Eukaryotes have developed complex signaling pathways to adapt to a readily changing environment, including the inositol phosphate (InsP ...
Caitlin Cridland, Glenda Gillaspy
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The Role of Inositol Hexakisphosphate Kinase in the Central Nervous System
Biomolecules, 2023 Inositol is a unique biological small molecule that can be phosphorylated or even further pyrophosphorylated on each of its six hydroxyl groups. These numerous phosphorylation states of inositol along with the kinases and phosphatases that interconvert ...
Tyler Heitmann, James C. Barrow
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Molecules, 2021 IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Raja Mohanrao +5 more
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MCK1 is a novel regulator of myo-inositol phosphate synthase (MIPS) that is required for inhibition of inositol synthesis by the mood stabilizer valproate. [PDF]
PLoS ONE, 2017 Myo-inositol, the precursor of all inositol compounds, is essential for the viability of eukaryotes. Identifying the factors that regulate inositol homeostasis is of obvious importance to understanding cell function and the pathologies underlying ...
Wenxi Yu +4 more
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Myo- inositol and its metabolites in abiotic stress tolerance in plants [PDF]
Journal of Stress Physiology & Biochemistry, 2022 Myo-inositol (MI) is a sugar-alcohol produced by most plants and animals. 1L-myo-Inositol- 1-phosphate synthase (MIPS) is the rate limiting enzyme that catalyzes the conversion of D-glucose 6- phosphate to 1L-myo-inositol-1-phosphate, the first step in ...
Raksha Mukhia, Dhani Raj Chhetri
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Poultry Science, 2023 This study investigated the effects of phytase and monocalcium phosphate supplementation on the dephosphorylation of phytic acid [myo-inositol 1,2,3,4,5,6-hexakis (dihydrogen phosphate); InsP6] in cecectomized laying hens using total excreta collection ...
W. Siegert +3 more
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Inositol Signaling in the Basidiomycete Fungus Schizophyllum commune
Journal of Fungi, 2021 Intracellular signaling is conserved in eukaryotes to allow for response to extracellular signals and to regulate development and cellular functions. In fungi, inositol phosphate signaling has been shown to be involved in growth, sexual reproduction, and
Reyna Murry +6 more
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Cell, 2010 Inositol diphosphates can transfer phosphatenonenzymatically to phosphoserine to generate diphosphate modi˜ed proteinsIP6K1 (KCS1) generated inositol diphosphatesare required for proper regulation of telomere lengthIpk2 regulates activity of Swi/Snf and Ino80chromatin-remodeling complexes in yeastIP6K1 (KCS1) is required for proper vacuole morphology ...
Hatch, Ace J., York, John D.
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