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Insulin Signaling: Inositol Phosphates Get Into the Akt [PDF]

Cell, 2010
An acute but transient response to insulin is essential for glucose homeostasis in mammals. Chakraborty et al. (2010) uncover a new feedback mechanism regulating insulin signaling. They show that the inositol pyrophosphate IP7, which is produced in response to insulin, inhibits the Akt kinase, a primary effector of insulin signaling.
Brendan D Manning
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Inositol phosphates and cell signalling

Nature, 1989
Inositol 1,4,5-trisphosphate is a second messenger which regulates intracellular calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by stimulating calcium entry. In these actions it may function with its phosphorylated metabolite, inositol 1,3,4,5-tetrakisphosphate. The subtlety of calcium regulation by inositol phosphates
M J, Berridge, R F, Irvine
openaire   +2 more sources

Inositol Phosphate Metabolism and Signal Transduction

American Review of Respiratory Disease, 1990
Abstract Activation of a variety of cell surface receptors results in a biphasic increase in the cytoplasmic Ca2+ concentration, due to the release or mobilization of intracellular Ca2+ stores and to the entry of Ca2+ from the extracellular space.
A R, Hughes, D A, Horstman, H, Takemura, J W, Putney   +3 more
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Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective [PDF]

Trends in Biochemical Sciences, 2017
Phosphate, as a cellular energy currency, essentially drives most biochemical reactions defining living organisms, and thus its homeostasis must be tightly regulated.
Adolfo Saiardi, Cristina Azevedo
exaly   +1 more source

Inositol Pyrophosphate InsP8 Acts as an Intracellular Phosphate Signal in Arabidopsis [PDF]

Molecular Plant, 2019
The maintenance of cellular phosphate (Pi) homeostasis is of great importance in living organisms. The SPX domain-containing protein 1 (SPX1) proteins from both Arabidopsis and rice have been proposed to act as sensors of Pi status. The molecular signal indicating the cellular Pi status and regulating Pi homeostasis in plants, however, remains to be ...
Jinsong Dong, Henning J Jessen, Dong Liu
exaly   +4 more sources

Inositol Phosphates and Energy Signaling in Plants

The FASEB Journal, 2017
Inositol phosphates (InsPs) are water soluble signaling molecules in plants whose phosphate profile (number of phosphate and position of attachment) specifies a unique type of cellular language that plants use in intracellular communication and in responding to changes in their environment.
Olusegun Adeboye Adepoju, Sarah Phoebe Williams, Glenda Gillaspy   +2 more
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The versatility of inositol phosphates as cellular signals

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1998
Cells from across the phylogenetic spectrum contain a variety of inositol phosphates. Many different functions have been ascribed to this group of compounds. However, it is remarkable how frequently several of these different inositol phosphates have been linked to various aspects of signal transduction.
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The Inositol Phosphate-Calcium Signaling System in Nonexcitable Cells

Endocrine Reviews, 1993
I. Introduction IN 1983, Michael Berridge proposed (1), and subsequently with collaborators demonstrated (2), that d-myo-inositol 1,4,5-trisphosphate [(1,4,5)IP3], generated in the course of receptor-activated inositol lipid turnover, was a second messenger signaling the release of stored calcium from intracellular sites to the cytoplasm of activated ...
J W, Putney, G S, Bird
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