Results 231 to 240 of about 1,340,779 (272)

Inositol phosphates and calcium signaling

Free Radical Biology and Medicine, 1993
This volume is devoted to the inositol phosphate-calcium signalling system, a cellular signalling system that plays a crucial role in diverse biological processes, influences the actions of drugs and hormones used to treat a wide variety of clinical disorders, and is implicated in the actions of growth factors and oncogene products. More than 30 of the
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Inositol Phosphate Metabolism and Cellular Signal Transduction

1989
Over thirty years have now past since the original report by Hokin and Hokin of receptor-stimulated turnover of inositol lipids1. Today, the impact of this phenomenon on a multitude of important biological systems is widely appreciated. Since the first papers by the Hokins, the phosphoinositides have enjoyed periods of interest, neglect, controversy ...
J W, Putney, A R, Hughes, D A, Horstman, H, Takemura   +3 more
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Are inositol pyrophosphates signalling molecules?

Journal of Cellular Physiology, 2009
AbstractThe inositol polyphosphate family of small, cytosolic molecules has a prominent place in the field of cell signalling, and inositol pyrophosphates are the most recent addition to this large family. First identified in 1993, they have since been found in all eukaryotic organisms studied.
Burton, Adam, Hu, Xiaowen, Saiardi, Adolfo   +2 more
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Osmotic stress‐induced phosphoinositide and inositol phosphate signalling in plants

Plant, Cell & Environment, 2010
ABSTRACTPolyphosphoinositides (PPIs) became famous for their role in inositol‐1,4,5‐trisphosphate (InsP3) mediated‐Ca2+ signalling in mammalian cells, generated through signal‐activated phospholipase C (PLC) hydrolysis of the minor membrane lipid, phosphatidylinositol‐4,5‐bisphosphate. For many years, the plant field followed the same paradigm, however,
Munnik, T., Vermeer, J.E.M.
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Inositol phosphates: a family of signal molecules?

Trends in Neurosciences, 1988
he inositol phospholipid-depen- dent signal transduction path- way is now considered to play an important part in controlling the functions of a variety of cell types within the nervous system. The second messenger roles of inositol (1,4, 5)-trisphosphate [(1,4,5)IP3] and 1,2-diacylglycerol have been established by injection of inositol phosphates into
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Inositol phosphates and cell signaling: new views of InsP5 and InsP6

Trends in Biochemical Sciences, 1993
Ins(1,3,4,5,6)P5 and InsP6 comprise the bulk of the inositol phosphate content of mammalian cells, but their intracellular functions are unknown. Until recently it seemed that these compounds were metabolically lethargic; this has diverted attention away from their possible role in short-term regulation of physiological processes.
F S, Menniti, K G, Oliver, J W, Putney, S B, Shears   +3 more
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The Role of Phosphoinositides and Inositol Phosphates in Plant Cell Signaling

2013
Work over the recent years has greatly expanded our understanding of the specific molecules involved in plant phosphoinositide signaling. Physiological approaches, combined with analytical techniques and genetic mutants have provided tools to understand how individual genes function in this pathway.
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Inositol phosphates and [Ca2+]i signals in a differentiating exocrine cell

American Journal of Physiology-Cell Physiology, 1991
Generation of inositol phosphates and changes in intracellular Ca2+ concentration [( Ca2+]i) upon muscarinic receptor activation were studied in isolated cells from the nasal salt gland of Anas platyrhynchos, comparing responses in the poorly differentiated cells from ducks drinking only tap water (naive cells) with the more fully differentiated ...
J P, Hildebrandt, T J, Shuttleworth
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The Inositol Phosphate-Calcium Signalling System in Lacrimal Gland Cells

1994
From the above discussion, it is clear that the regulation of Ca2+ signalling in exocrine cells is a complex process involving activation of both intracellular Ca2+ release as well as the entry of Ca2+ across the plasma membrane. A poorly understood mechanism links these two phases of Ca2+ signalling thereby providing both rapid as well as sustained ...
J W, Putney, G S, Bird
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How do inositol phosphates regulate calcium signaling?

The FASEB Journal, 1989
Activation of a variety of cell surface receptors results in the phospholipase C‐catalyzed hydrolysis of the minor plasma membrane phospholipid phosphatidylinositol 4,5‐bisphosphate, with concomitant formation of inositol 1,4,5‐trisphosphate and diacylglycerol.
J W, Putney, H, Takemura, A R, Hughes, D A, Horstman, O, Thastrup   +4 more
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