Results 71 to 80 of about 1,340,779 (272)

IP₇-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery

mBio, 2020
In the human-pathogenic fungus Cryptococcus neoformans, the inositol polyphosphate signaling pathway is critical for virulence. We recently demonstrated the key role of the inositol pyrophosphate IP7 (isomer 5-PP-IP5) in driving fungal virulence; however,
Desmarini Desmarini, Sophie Lev, David Furkert, Ben Crossett, Adolfo Saiardi, Keren Kaufman-Francis, Cecilia Li, Tania C. Sorrell, Lorna Wilkinson-White, Jacqueline Matthews, Dorothea Fiedler, Julianne Teresa Djordjevic   +11 more
doaj   +1 more source

Cell cycle-dependent regulation of structure of endoplasmic reticulum and inositol 1,4,5-trisphosphate-induced Ca2+ release in mouse oocytes and embryos [PDF]

, 2003
The organization of endoplasmic reticulum (ER) was examined in mouse eggs undergoing fertilization and in embryos during the first cell cycle. The ER in meiosis 11 (MII)-arrested mouse eggs is characterized by accumulations (clusters) that are restricted
Carroll, J, Marangos, P, FitzHarris, G
core  

RNAi-mediated silencing of the myo-inositol-1-phosphate synthase gene (GmMIPS1) in transgenic soybean inhibited seed development and reduced phytate content

, 2015
Inositol plays a role in membrane trafficking and signaling in addition to regulating cellular metabolism and controlling growth. In plants, the myo-inositol-1-phosphate is synthesized from glucose 6-phosphate in a reaction catalyzed by the enzyme myo ...
Rech, EL, Aragao, FJL, Amaya-Farfan, J, Cuneo, F, de Capdeville, G, Nunes, ACS, Vianna, GR   +6 more
core   +1 more source

VCP‐Regulated LMF2 Stabilizes the Cholesterol Biosynthesis Enzyme HMGCS1 to Drive Cancer Progression and Confer Capecitabine Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Qian Zhao, Lisa Andriani, Yin‐Ling Zhang, Shao‐Ying Yang, Yun‐Xiao Ling, Min‐Ying Huang, Jia‐Yang Cai, Fang‐Lin Zhang, Xin Hu, A‐Yong Cao, Zhi‐Min Shao, Guang‐Yu Liu, Da‐Qiang Li   +12 more
wiley   +1 more source

Polyphosphate Copper Nanospheres Drive Mitochondrial Metabolic Reprogramming via Calcium Phase Separation for Self‐Sensitizing Cuproptosis

Advanced Science, EarlyView.
This study developed polyphosphate (polyP)‐based nanostructures that enable calcium‐mediated metabolic reprogramming via liquid–liquid phase separation (LLPS). Released polyP undergoes LLPS with Ca2+, suppressing glycolytic flux and enhancing mitochondrial metabolism effectively.
Jing Wang, Xinyang Zhao, Zifeng Huang, Jingyi Zhang, Yucheng Tao, Yong Huang, Zijian Guo, Lei Dong, Xiuxiu Wang, Jing Zhao, Wei Wei   +10 more
wiley   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

Involvement of inositol biosynthesis and nitric oxide in the mediation of UV-B induced oxidative stress

Frontiers in Plant Science, 2016
The involvement of NO-signaling in ultraviolet B (UV-B) induced oxidative stress in plants is an open question. Inositol biosynthesis contributes to numerous cellular functions, including the regulation of plants tolerance to stress.
Dmytro I Lytvyn, Cécile eRaynaud, Alla I. Yemets, Catherine eBergounioux, Yaroslav B. Blume   +4 more
doaj   +1 more source

Full-length transcriptome profiling reveals insight into the cold response of two kiwifruit genotypes (A. arguta) with contrasting freezing tolerances

BMC Plant Biology, 2021
Background Kiwifruit (Actinidia Lindl.) is considered an important fruit species worldwide. Due to its temperate origin, this species is highly vulnerable to freezing injury while under low-temperature stress. To obtain further knowledge of the mechanism
Shihang Sun, Miaomiao Lin, Xiujuan Qi, Jinyong Chen, Hong Gu, Yunpeng Zhong, Leiming Sun, Abid Muhammad, Danfeng Bai, Chungen Hu, Jinbao Fang   +10 more
doaj   +1 more source

1L-myo-Inositol-1-phosphate synthase

, 1997
1L-myo-Inositol-1-phosphate synthase catalyzes the conversion of d-glucose 6-phosphate to 1l-myo-inositol 1-phosphate, the first committed step in the production of all inositol-containing compounds, including phospholipids, either directly or by
Johnson, Margaret D., Majumder, Arun Lahiri, Henry, Susan A., Arun Lahiri Majumder, Susan A Henry, Margaret D Johnson   +5 more
core   +1 more source

Effect of sorbitol, L-sorbose and inositol on myo-inositol-1-phosphate synthase activity in Neurospora crassa strains [PDF]

, 1984
Effect of sorbitol, L-sorbose and inositol on myo-inositol-1-phosphate synthase activity in Neurospora crassa ...
Kiss, A., Szabo, G., M. Schablik, Zsindely, A., G. Szabo, A. Kiss, Schablik, M., A. Zsindely   +7 more
core   +1 more source