Results 81 to 90 of about 1,340,779 (272)

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast

mBio
Inositol pyrophosphates 5-IP7, 1-IP7, and 1,5-IP8 are eukaryal signaling molecules that influence cell physiology, especially phosphate homeostasis. In fission yeast, 1,5-IP8 and 1-IP7 impact gene expression by acting as agonists of RNA 3'-processing and
Beate Schwer, Isabel Prucker, Ana M. Sanchez, Jill Babor, Henning J. Jessen, Stewart Shuman   +5 more
doaj   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Kcs1 and Vip1: The Key Enzymes behind Inositol Pyrophosphate Signaling in Saccharomyces cerevisiae

Biomolecules
The inositol pyrophosphate pathway, a complex cell signaling network, plays a pivotal role in orchestrating vital cellular processes in the budding yeast, where it regulates cell cycle progression, growth, endocytosis, exocytosis, apoptosis, telomere ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Ileana Cornelia Farcasanu   +2 more
doaj   +1 more source

Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase

, 2019
Scyllo-Inositol phosphates, which are among the stereoisomers of myo-inositol phosphate, can have 15 possible regio-isomers including three enantiomeric pairs: scyllo-I(1,2)P-2, scyllo-I(1,2,4)P-3, Scyllo-I(1,2,3,4)P-4.
Kwon, YU, Choi, G, Im, J, Chung, SK, Kim, YS, Choi, KY   +5 more
core   +1 more source

Regulatory effect of inositol on the synthesis of myo-inositol-1-phosphate synthase in Neurospora crassa strains. [PDF]

, 1982
Regulatory effect of inositol on the synthesis of myo-inositol-1-phosphate synthase in Neurospora crassa ...
Szabolics, M., Kiss, A., Szabo., G., M. Schablik, Zsindely, A, A Zsindely, A. Kiss, Schablik, M., M. Szabolics, G. Szabo.   +9 more
core   +1 more source

Proteomic Profiling of Xenobiotic and Nutrient Transporters in Human Placenta of Different Gestational Ages

Clinical Pharmacology &Therapeutics, EarlyView.
The placenta serves a critical role in nutrient uptake and waste elimination for the developing fetus. The placenta is also responsible for the uptake and/or exchange of xenobiotics, including medications, between the maternal and fetal bloodstreams. An estimated 40–80% of women take medications or drugs during pregnancy.
Eric M. Weaver, Ariel Topletz‐Erickson, Edward J. Kelly, Joanne Wang, Nina Isoherranen, Jashvant D. Unadkat, Samuel L.M. Arnold   +6 more
wiley   +1 more source

Science: Pathogenic fungi exploit plant phosphate sensing via Nudix hydrolase effectors

Advanced Agrochem
Inorganic phosphate (Pi) homeostasis in plants is regulated by inositol pyrophosphates (PP-InsPs), which mediate phosphate starvation responses. While beneficial microorganisms, such as arbuscular mycorrhizal fungi, contribute to phosphate uptake ...
Yi-Xuan Fu, Ying Ye
doaj   +1 more source

Myo-inositol oxygenase is required for responses to low energy conditions in Arabidopsis thaliana

Frontiers in Plant Science, 2012
myo-Inositol is a precursor for cell wall components, is used as a backbone of myo-inositol trisphosphate (Ins(1,4,5)P3) and phosphatidylinositol phosphate signaling molecules, and is debated about whether it is also a precursor in an alternate ascorbic ...
Shannon R Alford, Padma eRangarajan, Sarah Phoebe Williams, Glenda E Gillaspy   +3 more
doaj   +1 more source

Effect of inositol analogues on the production of myo-inositol-1-phosphate synthase in Neurospora crassa slime strain. [PDF]

, 1988
Effect of inositol analogues on the production of myo-inositol-1-phosphate synthase in Neurospora crassa slime ...
Kiss, A., Szabo, G., M. Schablik, Zsindely, A., G. Szabo, A. Kiss, Schablik, M., A. Zsindely   +7 more
core   +1 more source