Results 1 to 10 of about 4,494 (124)
Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs. [PDF]
Chemistry, 2023 AbstractInositol pyrophosphates (PP−IPs) are densely phosphorylated messenger molecules involved in numerous biological processes. PP−IPs contain one or two pyrophosphate group(s) attached to a phosphorylated myo‐inositol ring. 5PP−IP5 is the most abundant PP−IP in human cells. To investigate the function and regulation by PP−IPs in biological contexts,
Hostachy S +8 more
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The inositol pyrophosphate pathway in health and diseases. [PDF]
Biol Rev Camb Philos Soc, 2018 ABSTRACTInositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds and fungi to mammals. Distinct classes of kinases generate different forms of energetic diphosphate‐containing IPPs from inositol phosphates (IPs). Conversely, polyphosphate phosphohydrolase enzymes dephosphorylate IPPs to regenerate the respective IPs ...
Chakraborty A.
europepmc +5 more sources
Biosynthesis and possible functions of inositol pyrophosphates in plants [PDF]
Frontiers in Plant Science, 2015 Inositol phosphates (InsPs) are intricately tied to lipid signaling, as at least one portion of the inositol phosphate signaling pool is derived from hydrolysis of the lipid precursor, phosphatidyl inositol (4,5) bisphosphate. The focus of this review is on the inositol pyrophosphates, which are a novel group of InsP signaling molecules containing ...
Glenda Gillaspy, Imara Y Perera
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The Inositol Pyrophosphate Biosynthetic Pathway of Trypanosoma cruzi. [PDF]
ACS Chem Biol, 2021 Inositol phosphates (IPs) are phosphorylated derivatives of myo-inositol involved in the regulation of several cellular processes through their interaction with specific proteins. Their synthesis relies on the activity of specific kinases that use ATP as phosphate donor.
Mantilla BS +3 more
europepmc +4 more sources
Two inositol hexakisphosphate kinases drive inositol pyrophosphate synthesis in plants [PDF]
Plant Journal, 2014 SummaryInositol pyrophosphates are unique cellular signaling molecules with recently discovered roles in energy sensing and metabolism. Studies in eukaryotes have revealed that these compounds have a rapid turnover, and thus only small amounts accumulate.
Mihir Mandal +2 more
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Role of the inositol pyrophosphate multikinase Kcs1 in Cryptococcus inositol metabolism. [PDF]
Fungal Genet Biol, 2018 Cryptococcus neoformans is the most common cause of deadly fungal meningitis. This fungus has a complex inositol acquisition and utilization system, and our previous studies have shown the importance of inositol utilization in cryptococcal development and virulence. However, how inositol utilization is regulated in this fungus remains unknown.
Liao G +7 more
europepmc +5 more sources
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases. [PDF]
Molecules, 2020 In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat diet induced obesity, insulin resistance and fatty liver. IP6K1 generated 5-IP7 promotes insulin secretion from pancreatic β-cells, whereas it reduces insulin signaling in ...
Mukherjee S, Haubner J, Chakraborty A.
europepmc +6 more sources
Towards pharmacological intervention in inositol pyrophosphate signalling. [PDF]
Biochem Soc Trans, 2016 To help define the molecular basis of cellular signalling cascades, and their biological functions, there is considerable value in utilizing a high-quality chemical ‘probe’ that has a well-defined interaction with a specific cellular protein. Such reagents include inhibitors of protein kinases and small molecule kinases, as well as mimics or ...
Shears SB.
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Inositol Pyrophosphate Pyrotechnics [PDF]
Cell Metabolism, 2007 Physiologic roles of highly phosphorylated inositol phosphates, including those containing pyrophosphate groups, have been the focus of much recent interest. In the April 6, 2007 issue of Science, two papers (Lee et al., 2007; Mulugu et al., 2007) demonstrate the occurrence of a novel inositol pyrophosphate molecule in yeast and elucidate its role in ...
Solomon H. Snyder +2 more
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Preparation of Quality Inositol Pyrophosphates [PDF]
Journal of Visualized Experiments, 2011 Myo-inositol is present in nature either unmodified or in more complex phosphorylated derivates. Of the latest, the two most abundant in eukaryotic cells are inositol pentakisphosphate (IP(5;)) and inositol hexakisphosphate (phytic acid or IP(6;)).
Zsolt Szíjgyártó +4 more
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