Results 1 to 10 of about 98,783 (245)

Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast [PDF]

mBio
Inositol pyrophosphates 5-IP7, 1-IP7, and 1,5-IP8 are eukaryal signaling molecules that influence cell physiology, especially phosphate homeostasis. In fission yeast, 1,5-IP8 and 1-IP7 impact gene expression by acting as agonists of RNA 3'-processing and
Beate Schwer, Isabel Prucker, Ana M. Sanchez, Jill Babor, Henning J. Jessen, Stewart Shuman   +5 more
doaj   +4 more sources

Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81 [PDF]

eLife, 2023
Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate.
Valentin Chabert, Geun-Don Kim, Danye Qiu, Guizhen Liu, Lydie Michaillat Mayer, Muhammed Jamsheer K, Henning J Jessen, Andreas Mayer   +7 more
doaj   +4 more sources

Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast [PDF]

mBio, 2023
The inositol pyrophosphate signaling molecule 1,5-IP8 is an agonist of RNA 3'-processing and transcription termination in fission yeast that regulates the expression of phosphate acquisition genes pho1, pho84, and tgp1.
Lauren Bednor, Ana M. Sanchez, Angad Garg, Stewart Shuman, Beate Schwer   +4 more
doaj   +4 more sources

Synergistic activation of the human phosphate exporter XPR1 by KIDINS220 and inositol pyrophosphate [PDF]

Nature Communications
Inorganic phosphate (Pi) is essential for life, and its intracellular levels must be tightly regulated to avoid toxicity. XPR1, the sole known phosphate exporter, is critical for maintaining this balance.
Peng Zuo, Weize Wang, Zonglin Dai, Jiye Zheng, Shang Yu, Guangxi Wang, Yue Yin, Ling Liang, Yuxin Yin   +8 more
doaj   +6 more sources

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis [PDF]

eLife, 2019
Many eukaryotic proteins regulating phosphate (Pi) homeostasis contain SPX domains that are receptors for inositol pyrophosphates (PP-InsP), suggesting that PP-InsPs may regulate Pi homeostasis.
Jinsheng Zhu, Kelvin Lau, Robert Puschmann, Robert K Harmel, Youjun Zhang, Verena Pries, Philipp Gaugler, Larissa Broger, Amit K Dutta, Henning J Jessen, Gabriel Schaaf, Alisdair R Fernie, Ludwig A Hothorn, Dorothea Fiedler, Michael Hothorn   +14 more
doaj   +4 more sources

Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP₇ [PDF]

Biomolecules, 2023
Inositol pyrophosphates (PP-InsPs); are a functionally diverse family of eukaryotic molecules that deploy a highly-specialized array of phosphate groups as a combinatorial cell-signaling code.
Soumyadip Sahu, Jacob Gordon, Chunfang Gu, Mack Sobhany, Dorothea Fiedler, Robin E. Stanley, Stephen B. Shears   +6 more
doaj   +3 more sources

Biosynthesis and possible functions of inositol pyrophosphates in plants [PDF]

Frontiers in Plant Science, 2015
Inositol phosphates (InsPs) are intricately tied to lipid signaling, as at least one portion of the inositol phosphate signaling pool is derived from hydrolysis of the lipid precursor, phosphatidyl inositol (4,5) bisphosphate. The focus of this review is
Sarah Phoebe Williams, Glenda E Gillaspy, Imara Yasmin Perera   +2 more
doaj   +5 more sources

Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus [PDF]

The EMBO Journal
Kinases that synthesize inositol phosphates (IPs) and pyrophosphates (PP-IPs) control numerous biological processes in eukaryotic cells. Herein, we extend this cellular signaling repertoire to viruses. We have biochemically and structurally characterized
Guangning Zong, Yann Desfougères, Paloma Portela-Torres, Yong-Uk Kwon, Adolfo Saiardi, Stephen B. Shears, Huanchen Wang   +6 more
doaj   +3 more sources

Analysis of Dictyostelium discoideum inositol pyrophosphate metabolism by gel electrophoresis. [PDF]

PLoS ONE, 2014
The social amoeba Dictyostelium discoideum was instrumental in the discovery and early characterization of inositol pyrophosphates, a class of molecules possessing highly-energetic pyrophosphate bonds.
Francesca Pisani, Thomas Livermore, Giuseppina Rose, Jonathan Robert Chubb, Marco Gaspari, Adolfo Saiardi   +5 more
doaj   +3 more sources

Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis

Nature Communications, 2021
Plants regulate phosphate homeostasis via the interaction of PHR transcription factors with SPX receptors bound to inositol pyrophosphate signaling molecules.
Rebekka Wild, Jinsheng Zhu, Kristina Sturm   +2 more
exaly   +2 more sources