Results 121 to 130 of about 98,783 (245)

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Phytase: application in food industry [PDF]

, 2010
Phytates have been considered as a threat in human diet due to its antinutrients behaviour which known as strong chelators of divalent minerals such as Ca²+, Mg²+, Zn²+ and Fe²+.
Abd. Manap, Mohd. Yazid, Meor Hussin, Anis Shobirin, Mustafa, Shuhaimi, Suhairin, Afinah   +3 more
core  

Arabidopsis inositol phosphate kinases, IPK1 and ITPK1, constitute a metabolic pathway in maintaining phosphate homeostasis [PDF]

, 2018
Emerging studies have implicated a close link between inositol phosphate (InsP) metabolism and cellular phosphate (Pi) homeostasis in eukaryotes; however, whether a common InsP species is deployed as an evolutionarily conserved metabolic messenger to ...
Alcazar-Roman, Alexova, Auesukaree, Aung, Azevedo, Azevedo, Bari, Berridge, Boer, Bosch, Brearley, Brearley, Brearley, Brearley, Chamberlain, Chiou, Chiou, Cho, Choi, Clough, Curtis, Desai, Duff, Franco-Zorrilla, Gonzalez, Hammond, Hanke, Ho, Holford, Huang, Huang, Irvine, Kanehara, Karimi, Kim, Kuo, Kusano, Laha, Lee, Lee, Lee, Lemtiri-Chlieh, Lemtiri-Chlieh, Lin, Lin, Lin, Liu, Liu, Liu, Lonetti, Martin, Mosblech, Mulugu, Munnik, Munnik, Munnik, Murphy, Müller, Nagy, Norbis, Pant, Perera, Perera, Perera, Phillippy, Pradet, Puga, Raboy, Raboy, Rao, Rouached, Saiardi, Saiardi, Saiardi, Schell, Schneider, Secco, Secco, Shears, Stenzel, Stephens, Stephens, Stevenson-Paulik, Stevenson-Paulik, Sweetman, Szijgyarto, Torabinejad, Vajanaphanich, Voglmaier, Wang, Whiteford, Wild, Williams, Wilson, Wreggett, Wu, Wu, Wundenberg, Xiong, Xu, Xu, Yang, Yang, York, Zonia   +104 more
core   +2 more sources

NUDIX hydrolases target specific inositol pyrophosphates and regulate phosphate homeostasis and bacterial pathogen susceptibility in Arabidopsis

Journal of Integrative Plant Biology, Volume 67, Issue 12, Page 3123-3151, December 2025.
NUDIX‐type hydrolase enzymes of subclade I and II preferentially target the inositol pyrophosphate messengers 4‐ and 3‐InsP7, respectively. Inactivation of subclade II NUDTs disrupts phosphate homeostasis and enhances bacterial resistance, revealing connections between defense and nutrient signaling.
Robin Schneider, Klea Lami, Isabel Prucker, Sara Christina Stolze, Annett Strauß, Julie Marie Schmidt, Simon M. Bartsch, Kevin Langenbach, Esther Lange, Kevin Ritter, David Furkert, Natalie Faiß, Sandeep Kumar, M. Shamim Hasan, Athanasios Makris, Lukas Krusenbaum, Stefanie Wege, Yemisrach Zewdu Belay, Simon Kriescher, Jeremy The, Michael Harings, Florian M. W. Grundler, Martina K. Ried‐Lasi, Heiko Schoof, Philipp Gaugler, Marília Kamleitner, Dorothea Fiedler, Hirofumi Nakagami, Ricardo F. H. Giehl, Thomas Lahaye, Saikat Bhattacharjee, Henning J. Jessen, Verena Gaugler, Gabriel Schaaf   +33 more
wiley   +1 more source

Structural basis of phosphate export by human XPR1

Nature Communications
Phosphorus in crucial for all living organisms. In vertebrate, cellular phosphate homeostasis is partly controlled by XPR1, a poorly characterized inositol pyrophosphate-dependent phosphate exporter.
Qixian He, Ran Zhang, Sandrine Tury, Valérie Courgnaud, Fenglian Liu, Jean-luc Battini, Baobin Li, Qingfeng Chen   +7 more
doaj   +1 more source

Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate Signalling [PDF]

, 2017
Inositol polyphosphates, in their water-soluble or lipid-bound forms, represent a large and multifaceted family of signalling molecules. Some inositol polyphosphates are well recognised as defining important signal transduction pathways, as in the case ...
Saiardi, A, Wilson, MSC
core  

Simultaneous Knockout of Tk1‐SST and Tk1‐FFT via CRISPR/Cas9 Enhances the Natural Rubber Accumulation in Taraxacum kok‐saghyz

Plant Biotechnology Journal, Volume 23, Issue 12, Page 5654-5676, December 2025.
ABSTRACT Taraxacum kok‐saghyz (TKS) synthesises natural rubber (NR) and inulin using sucrose as a carbon source. However, molecular mechanisms regulating inulin and NR accumulation remain largely unclear. Here, we report the generation of double‐gene homozygous mutants, 1‐sst1‐fft, by simultaneously knocking out two key genes responsible for inulin ...
Bi Qin, Xue Hou, Songle Fan, Chuang Li, Xiaoxiao Wang, Qiuhui Chen, Yushuang Yang, Pin Lin, Liang RuiNan Lu, Canni Fu, Ning Yang, Qiaoli Gao, Shanshan Zheng, Shizhong Liu   +13 more
wiley   +1 more source

Automated resolution of chromatographic signals by independent component analysis-orthogonal signal deconvolution in comprehensive gas chromatography/mass spectrometry-based metabolomics [PDF]

, 2016
Comprehensive gas chromatography-mass spectrometry (GC x GC-MS) provides a different perspective in metabolomics profiling of samples. However, algorithms for GCx GC-MS data processing are needed in order to automatically process the data and extract the
Brezmes, Jesus, Domingo Almenara, Xavier, Perera Lluna, Alexandre, Ramirez, Noelia   +3 more
core   +2 more sources

Polyphosphate Accumulation Is Determined by Zinc and Inositol in Saccharomyces cerevisiae

Yeast, Volume 42, Issue 11, Page 249-260, November 2025.
Zinc and inositol supplementation during phosphate starvation significantly enhances final polyphosphate levels in S. cerevisiae. ABSTRACT Polyphosphate (polyP) is an intriguing polymer with diverse biological and industrial applications. Chemical polyP production is energy‐intensive and limited in chain length at large‐scale production. Alternatively,
Alexander Deitert, Makarius Baier, Roy Eerlings, Jana Fees, Ailín Österlein Kück, Julia Repin, Philipp Demling, Lars M. Blank   +7 more
wiley   +1 more source

Activities and genetic interactions of fission yeast Aps1, a Nudix-type inositol pyrophosphatase and inorganic polyphosphatase

mBio
Inositol pyrophosphate 1,5-IP8 regulates expression of a fission yeast phosphate homeostasis regulon, comprising phosphate acquisition genes pho1, pho84, and tgp1, via its action as an agonist of precocious termination of transcription of the upstream ...
Shreya Ghosh, Ana M. Sanchez, Beate Schwer, Isabel Prucker, Nikolaus Jork, Henning J. Jessen, Stewart Shuman   +6 more
doaj   +1 more source