Results 11 to 20 of about 12,071 (167)
Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective [PDF]
Trends in Biochemical Sciences, 2017 Phosphate, as a cellular energy currency, essentially drives most biochemical reactions defining living organisms, and thus its homeostasis must be tightly regulated. Investigation into the role of inositol pyrophosphates (PP-IPs) has provided a novel perspective on the regulation of phosphate homeostasis.
Azevedo, C, Saiardi, A
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Expedient synthesis and luminescence sensing of the inositol pyrophosphate cellular messenger 5-PP-InsP5. [PDF]
Chem Sci, 2023 Inositol pyrophosphates are important biomolecules associated with apoptosis, cell growth and kinase regulation, yet their exact biological roles are still emerging and probes do not exist for their selective detection.
Shipton ML +6 more
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Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry in S. pombe. [PDF]
J Fungi (Basel), 2022 Inositol pyrophosphates (IPPs) comprise a specific class of signaling molecules that regulate central biological processes in eukaryotes. The conserved Vip1/PPIP5K family controls intracellular IP8 levels, the highest phosphorylated form of IPPs present ...
Kuenzel NA +6 more
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Inositol Pyrophosphates Get the Vip1 Treatment [PDF]
Cell, 2007 Inositol pyrophosphates are unique signaling molecules implicated in the regulation of diverse cellular processes. Two new studies by Mulugu et al. (2007) and Lee et al. (2007) extend the biological and metabolic diversity of this class of molecules. They identify yeast Vip1 as a new inositol pyrophosphate synthase and show that the products of Vip1 ...
Sara Maria Nancy Onnebo, Adolfo Saiardi
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Crystal structure and enzymology of solanum tuberosum inositol tris/tetrakisphosphate kinase 1 (StITPK1) [PDF]
, 2023 Inositol phosphates and their pyrophosphorylated derivatives are responsive to the phosphate supply and are agents of phosphate homeostasis and other aspects of physiology. It seems likely that the enzymes that interconvert these signals work against the
Brearley, Charles A +7 more
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Scalable Chemoenzymatic Synthesis of Inositol Pyrophosphates [PDF]
Biochemistry, 2019 The inositol pyrophosphates (PP-InsPs) are an important group of cellular messengers that influence a broad range of biological processes. To elucidate the functions of these high-energy metabolites at the biochemical level, access to the purified molecules is required.
Robert Puschmann +2 more
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Structural insight into inositol pyrophosphate turnover [PDF]
Advances in Biological Regulation, 2013 The diphosphoinositol polyphosphates ("inositol pyrophosphates"; PP-InsPs) regulate many cellular processes in eukaryotes, including stress responses, apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, telomere maintenance, insulin signaling and neutrophil activation.
Huanchen Wang +2 more
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Inositol pyrophosphates regulate endocytic trafficking [PDF]
Proceedings of the National Academy of Sciences, 2002 The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established.
Beverly Wendland +4 more
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Versatile signaling mechanisms of inositol pyrophosphates
Current Opinion in Chemical Biology, 2022 Inositol pyrophosphates (PP-InsPs) constitute a group of highly charged messengers, which regulate central biological processes in health and disease, such as cellular phosphate and general energy homeostasis. Deciphering the molecular mechanisms underlying PP-InsP-mediated signaling remains a challenge due to the unique properties of these molecules ...
Minh Nguyen Trung +2 more
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The inositol pyrophosphate synthesis pathway in Trypanosoma brucei is linked to polyphosphate synthesis in acidocalcisomes. [PDF]
Mol Microbiol, 2017 Inositol pyrophosphates are novel signaling molecules possessing high-energy pyrophosphate bonds and involved in a number of biological functions. Here, we report the correct identification and characterization of the kinases involved in the inositol ...
Cordeiro CD, Saiardi A, Docampo R.
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