Results 11 to 20 of about 98,783 (245)

Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs. [PDF]

Chemistry, 2023
Inositol pyrophosphates (PP−IPs) are densely phosphorylated messenger molecules involved in numerous biological processes. PP−IPs contain one or two pyrophosphate group(s) attached to a phosphorylated myo‐inositol ring. 5PP−IP5 is the most abundant PP−IP
Hostachy S, Wang H, Zong G, Franke K, Riley AM, Schmieder P, Potter BVL, Shears SB, Fiedler D.   +8 more
europepmc   +8 more sources

Kcs1 and Vip1: The Key Enzymes behind Inositol Pyrophosphate Signaling in Saccharomyces cerevisiae [PDF]

Biomolecules
The inositol pyrophosphate pathway, a complex cell signaling network, plays a pivotal role in orchestrating vital cellular processes in the budding yeast, where it regulates cell cycle progression, growth, endocytosis, exocytosis, apoptosis, telomere ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Ileana Cornelia Farcasanu   +2 more
doaj   +3 more sources

Inositol pyrophosphates as multifaceted metabolites in the regulation of mammalian signaling networks [PDF]

Animal Cells and Systems, 2018
Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases,
Seung Ju Park, Seulgi Lee, Seung Eun Park, Seyun Kim   +3 more
doaj   +6 more sources

Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development. [PDF]

PLoS Genetics
Inositol pyrophosphates (PP-InsPs) are nutrient messengers whose cellular levels are precisely regulated. Diphosphoinositol pentakisphosphate kinases (PPIP5Ks) generate the active signaling molecule 1,5-InsP8.
Florian Laurent, Simon M Bartsch, Anuj Shukla, Felix Rico-Resendiz, Daniel Couto, Christelle Fuchs, Joël Nicolet, Sylvain Loubéry, Henning J Jessen, Dorothea Fiedler, Michael Hothorn   +10 more
doaj   +3 more sources

Structures of Fission Yeast Inositol Pyrophosphate Kinase Asp1 in Ligand-Free, Substrate-Bound, and Product-Bound States [PDF]

mBio, 2022
Expression of the fission yeast Schizosaccharomyces pombe phosphate regulon is sensitive to the intracellular level of the inositol pyrophosphate signaling molecule 1,5-IP8.
Bradley Benjamin, Yehuda Goldgur, Nikolaus Jork, Henning J. Jessen, Beate Schwer, Stewart Shuman   +5 more
doaj   +3 more sources

Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry in S. pombe [PDF]

Journal of Fungi, 2022
Inositol pyrophosphates (IPPs) comprise a specific class of signaling molecules that regulate central biological processes in eukaryotes. The conserved Vip1/PPIP5K family controls intracellular IP8 levels, the highest phosphorylated form of IPPs present ...
Natascha Andrea Kuenzel, Abel R. Alcázar-Román, Adolfo Saiardi, Simon M. Bartsch, Sarune Daunaraviciute, Dorothea Fiedler, Ursula Fleig   +6 more
doaj   +3 more sources

Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast [PDF]

mBio, 2022
Inositol pyrophosphate (IPP) dynamics govern expression of the fission yeast phosphate homeostasis regulon via their effects on lncRNA-mediated transcription interference.
Beate Schwer, Angad Garg, Ana M. Sanchez, Mindy A. Bernstein, Bradley Benjamin, Stewart Shuman   +5 more
doaj   +3 more sources

Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast PHO regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1 [PDF]

mBio
Inositol pyrophosphates are signaling molecules that regulate cellular phosphate homeostasis in eukaryal taxa. In fission yeast, where the phosphate regulon (comprising phosphate acquisition genes pho1, pho84, and tgp1) is repressed under phosphate ...
Beate Schwer, Aleksei Innokentev, Ana M. Sanchez, Angad Garg, Stewart Shuman   +4 more
doaj   +3 more sources

Elevation of inositol pyrophosphate IP₇ in the mammalian spinal cord of amyotrophic lateral sclerosis. [PDF]

Front Neurol, 2023
Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder associated with progressive impairment of spinal motor neurons. Continuous research endeavor is underway to fully understand the molecular mechanisms associating with ...
Ito M, Fujii N, Kohara S, Tanaka M, Takao M, Mihara B, Saito Y, Mizuma A, Nakayama T, Netsu S, Suzuki N, Kakita A, Nagata E.   +12 more
europepmc   +4 more sources

Inositol pyrophosphate catabolism by three families of phosphatases controls plant growth and development [PDF]

bioRxiv
Inositol pyrophosphates (PP-InsPs) are nutrient messengers whose cellular concentration must be tightly regulated. Diphosphoinositol pentakisphosphate kinases (PPIP5Ks) generate the active signaling molecule 1,5-InsP8.
Laurent F, Bartsch SM, Shukla A, Rico-Resendiz F, Couto D, Fuchs C, Nicolet J, Loubéry S, Jessen HJ, Fiedler D, Hothorn M.   +10 more
europepmc   +3 more sources