Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin. [PDF]
Cardiovasc ResAims Adiponectin is an adipocyte-derived circulating protein that exerts cardiovascular and metabolic protection. Due to the futile degradation of endogenous adiponectin and the challenges of exogenous administration, regulatory mechanisms of adiponectin
Fu L +12 more
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Towards pharmacological intervention in inositol pyrophosphate signalling. [PDF]
Biochem Soc Trans, 2016 To help define the molecular basis of cellular signalling cascades, and their biological functions, there is considerable value in utilizing a high-quality chemical ‘probe’ that has a well-defined interaction with a specific cellular protein. Such reagents include inhibitors of protein kinases and small molecule kinases, as well as mimics or ...
Shears SB.
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Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants? [PDF]
Molecules, 2020 The ability of an organism to maintain homeostasis in changing conditions is crucial for growth and survival. Eukaryotes have developed complex signaling pathways to adapt to a readily changing environment, including the inositol phosphate (InsP ...
Caitlin Cridland, Glenda Gillaspy
doaj +2 more sources
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases [PDF]
Molecules, 2020 In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat diet induced obesity, insulin resistance and fatty liver. IP6K1 generated
Sandip Mukherjee +2 more
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Inositol Pyrophosphate Metabolism Regulates Presynaptic Vesicle Cycling at Central Synapses [PDF]
iScience, 2020 Summary: The coordination of synaptic vesicle exocytosis and endocytosis supports neurotransmitter release from presynaptic terminals. Although inositol pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (5-IP7), are versatile signaling ...
Seung Ju Park +6 more
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Preparation of Quality Inositol Pyrophosphates [PDF]
Journal of Visualized Experiments, 2011 Myo-inositol is present in nature either unmodified or in more complex phosphorylated derivates. Of the latest, the two most abundant in eukaryotic cells are inositol pentakisphosphate (IP5) and inositol hexakisphosphate (phytic acid or IP6). IP5 and IP6
Azevedo, Cristina +4 more
core +5 more sources
Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective [PDF]
Trends in Biochemical Sciences, 2017 Phosphate, as a cellular energy currency, essentially drives most biochemical reactions defining living organisms, and thus its homeostasis must be tightly regulated.
Azevedo, C, Saiardi, A
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Wheat inositol pyrophosphate kinase TaVIH2-3B modulates cell-wall composition and drought tolerance in Arabidopsis [PDF]
BMC Biology, 2021 Background Inositol pyrophosphates (PP-InsPs) are high-energy derivatives of inositol, involved in different signalling and regulatory responses of eukaryotic cells.
Anuj Shukla +12 more
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Arabidopsis PFA-DSP-Type Phosphohydrolases Target Specific Inositol Pyrophosphate Messengers. [PDF]
Biochemistry, 2022 Gaugler P +17 more
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