Inositol Pyrophosphates as Mammalian Cell Signals [PDF]
Science Signaling, 2011 Identification and knockout of their biosynthetic enzymes has shed light on the diverse functions of the inositol pyrophosphates.
Chakraborty, A Chakraborty, Anutosh +2 more
openaire +2 more sources
Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease [PDF]
, 2016 Maintenance of electric potential and synaptic transmission are energetically demanding tasks that neuronal metabolism must continually satisfy. Inability to fulfil these energy requirements leads to the development of neurodegenerative disorders ...
Bruni, AC +6 more
core +1 more source
Inositol pyrophosphates inhibit synaptotagmin-dependent exocytosis [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Inositol phosphates have long been considered to be negative regulators of synaptic exocytosis, but the function of diphosphoinositol pentakisphosphate (IP 7 ) has remained elusive. We found that overexpression and depletion of inositol hexakisphosphate (IP 6 ) kinase ...
Lee, Tae-Sun +14 more
openaire +4 more sources
Metabolic engineering of micronutrients in crop plants [PDF]
, 2016 Micronutrient deficiency is a widespread phenomenon, most prevalent in developing countries. Being causally linked to the occurrence of a range of diseases, it affects billions of people worldwide. Enhancing the content of micronutrients in crop products
Blancquaert, Dieter +3 more
core +2 more sources
Protein pyrophosphorylation: moving forward [PDF]
, 2016 Genetic ablation of inositol pyrophosphate synthesis has established the fundamental importance of this class of molecules to the eukaryote cell. These studies, however, must be complemented by cell biology and biochemical approaches to appreciate the ...
Saiardi, A
core +3 more sources
Has Inositol Played Any Role in the Origin of Life? [PDF]
, 2017 Phosphorus, as phosphate, plays a paramount role in biology. Since phosphate transfer reactions are an integral part of contemporary life, phosphate may have been incorporated into the initial molecules at the very beginning.
Saiardi, A
core +1 more source
Inositol Pyrophosphates Inhibit Synaptotagmin-Dependent Exocytosis [PDF]
Biophysical Journal, 2014 Inositol pyrophosphates such as IP7 (5-diphosphoinositol pentakisphosphate) are highly energetic inositol metabolites containing pyrophosphate bonds. While IP7 are known to regulate various biological events like metabolism, the molecular site of IP7 action in vesicle trafficking remains elusive.
Lee, TS Lee, Tae Sun +10 more
openaire +2 more sources
Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes [PDF]
, 2014 Type 2 diabetes is a metabolic disease categorized primarily by reduced insulin sensitivity, β-cell dysfunction, and elevated hepatic glucose production.
Elliott, B.T. +3 more
core +4 more sources
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event [PDF]
Proceedings of the National Academy of Sciences, 2007 In a previous study, we showed that the inositol pyrophosphate diphosphoinositol pentakisphosphate (IP 7 ) physiologically phosphorylates mammalian and yeast proteins. We now report that this phosphate transfer reflects pyrophosphorylation. Thus, proteins must be prephosphorylated by ATP to prime them for IP
Akhilesh Pandey +14 more
openaire +3 more sources
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase is a distant IPK member with a singular inositide binding site for axial 2-OH recognition [PDF]
, 2010 Inositol phosphates (InsPs) are signaling molecules with multiple roles in cells. In particular Graphic (InsP6) is involved in mRNA export and editing or chromatin remodeling among other events.
Agarwal +35 more
core +2 more sources