Results 31 to 40 of about 98,783 (245)

Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line. [PDF]

Proc Natl Acad Sci U S A, 2021
Gu C, Liu J, Liu X, Zhang H, Luo J, Wang H, Locasale JW, Shears SB.   +7 more
europepmc   +3 more sources

Inositol Pyrophosphates Get the Vip1 Treatment [PDF]

Cell, 2007
Inositol pyrophosphates are unique signaling molecules implicated in the regulation of diverse cellular processes. Two new studies by Mulugu et al. (2007) and Lee et al. (2007) extend the biological and metabolic diversity of this class of molecules. They identify yeast Vip1 as a new inositol pyrophosphate synthase and show that the products of Vip1 ...
Sara Maria Nancy Onnebo, Adolfo Saiardi
openalex   +3 more sources

Lotus japonicus VIH2 is an inositol pyrophosphate synthase that regulates arbuscular mycorrhiza [PDF]

bioRxiv
Plant yield is often maximized by the extensive use of mineral fertilizers, which, however, has severe environmental consequences. Phosphate is particularly problematic, as it represents a globally limited resource, and its runoff and soil erosion ...
K. N. ANIL RAJ, Verena Gaugler, Mengsi Lu, Maren Schaedel, Philipp Gaugler, Charlotte M. M. Grothaus, Ulrike A. Jochimsen, Guizhen Liu, Michael Harings, Henning J. Jessen, Gabriel Schaaf, Martina Katharina Ried   +11 more
openalex   +2 more sources

β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner. [PDF]

Proc Natl Acad Sci U S A, 2023
Significance Inositol pyrophosphates (PP-InsPs) are messenger molecules regulating various functions in mammals. They are associated with the oxidative stress response, but the underlying mechanism is unclear.
Eisenbeis VB, Qiu D, Gorka O, Strotmann L, Liu G, Prucker I, Su XB, Wilson MSC, Ritter K, Loenarz C, Groß O, Saiardi A, Jessen HJ.   +12 more
europepmc   +2 more sources

Conservation of heat stress acclimation by the IPK2-type kinases that control the synthesis of the inositol pyrophosphate 4/6-InsP7 in land plants. [PDF]

PLoS Genet
Inositol pyrophosphates (PP-InsPs) are soluble cellular messengers that integrate environmental cues to induce adaptive responses in eukaryotes. In plants, the biological functions of various PP-InsP species are poorly understood, largely due to the ...
Yadav R, Liu G, Rana P, Pullagurla NJ, Qiu D, Jessen HJ, Laha D.   +6 more
europepmc   +2 more sources

Expanding the Inositol Pyrophosphate Toolbox: Stereoselective Synthesis and Application of PP-InsP₄ Isomers in Plant Signaling. [PDF]

Angew Chem Int Ed Engl
Inositol pyrophosphates (PP‐InsPs) are highly phosphorylated signaling molecules that regulate diverse cellular processes, including phosphate homeostasis and energy metabolism across species. Despite extensive research on well‐characterized exhaustively
Ritter K, Braun AC, Liu G, Lu M, Gaugler V, Schaaf G, Jessen HJ.   +6 more
europepmc   +2 more sources

Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling. [PDF]

Biomed Pharmacother, 2023
Qi J, Cheng W, Gao Z, Chen Y, Shipton ML, Furkert D, Chin AC, Riley AM, Fiedler D, Potter BVL, Fu C.   +10 more
europepmc   +2 more sources

A linear pathway for inositol pyrophosphate metabolism revealed by 18O labeling and model reduction. [PDF]

PLoS Comput Biol
The homeostasis of intracellular inorganic phosphate is essential for eukaryotic metabolism and is regulated by the INPHORS signalling pathway, which employs inositol pyrophosphates (IPPs) as key intermediary messengers.
Hermes J, Kim GD, Liu G, De Leo MG, Mayer A, Jessen H, Timmer J.   +6 more
europepmc   +2 more sources

Enhancing inositol pyrophosphate accumulation in plants alters growth, phosphate homeostasis, and insect herbivory. [PDF]

Plant J
SUMMARY Phosphate (Pi) is a critical nutrient for plants and is often a limiting factor in food production, as many agricultural soils are limited in available Pi.
Cridland C, Russo A, Craige B, Donahue J, Zhang XM, Payne M, Gillaspy G, Freed C.   +7 more
europepmc   +2 more sources

Phosphorus-specific, liquid chromatography inductively coupled plasma mass spectrometry for analysis of inositol phosphate and inositol pyrophosphate metabolism. [PDF]

Biochem J
Inositol phosphate (InsP) and diphosphoinositol phosphate (PP-InsP) analysis in tissues is plagued by multiple difficulties of sensitivity, regioisomer resolution and the need for radiolabelling with metabolic precursors.
Sprigg C, Whitfield HL, Leftwich PT, Kuo HF, Chiou TJ, Saiardi A, Shipton ML, Riley AM, Potter BVL, Scholey D, Burton E, Bedford MR, Brearley CA.   +12 more
europepmc   +2 more sources