Results 41 to 50 of about 98,783 (245)

Expedient synthesis and luminescence sensing of the inositol pyrophosphate cellular messenger 5-PP-InsP₅. [PDF]

Chem Sci, 2023
Inositol pyrophosphates are important biomolecules associated with apoptosis, cell growth and kinase regulation, yet their exact biological roles are still emerging and probes do not exist for their selective detection.
Shipton ML, Jamion FA, Wheeler S, Riley AM, Plasser F, Potter BVL, Butler SJ.   +6 more
europepmc   +2 more sources

Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate [PDF]

Proceedings of the National Academy of Sciences, 2001
Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK).
Adolfo Saiardi, Eiichiro Nagata, Hongbo R. Luo, Akira Sawa, Xiaojiang Luo, Adele M. Snowman, Solomon H. Snyder   +6 more
openalex   +4 more sources

Activities, substrate specificity, and genetic interactions of fission yeast Siw14, a cysteinyl-phosphatase-type inositol pyrophosphatase

mBio, 2023
Inositol pyrophosphate 1,5-IP8 is a signaling molecule that regulates phosphate and polyphosphate homeostasis in the fission yeast Schizosaccharomyces pombe. 1,5-IP8 levels are dictated by a balance between the Asp1 kinase domain that converts 5-IP7 to 1,
Ana M. Sanchez, Beate Schwer, Nikolaus Jork, Henning J. Jessen, Stewart Shuman   +4 more
doaj   +1 more source

Inositol Pyrophosphate Pyrotechnics [PDF]

Cell Metabolism, 2007
Physiologic roles of highly phosphorylated inositol phosphates, including those containing pyrophosphate groups, have been the focus of much recent interest. In the April 6, 2007 issue of Science, two papers (Lee et al., 2007; Mulugu et al., 2007) demonstrate the occurrence of a novel inositol pyrophosphate molecule in yeast and elucidate its role in ...
Bhandari, Rashna, Chakraborty, Anutosh, Snyder, Solomon H.   +2 more
openaire   +2 more sources

Regulation of Inositol Metabolism Is Fine-tuned by Inositol Pyrophosphates in Saccharomyces cerevisiae* [PDF]

Journal of Biological Chemistry, 2013
Although inositol pyrophosphates have diverse roles in phosphate signaling and other important cellular processes, little is known about their functions in the biosynthesis of inositol and phospholipids. Here, we show that KCS1, which encodes an inositol pyrophosphate kinase, is a regulator of inositol metabolism.
Cunqi Ye, W. M. M. S. Bandara, Miriam L. Greenberg   +2 more
openalex   +4 more sources

Novel Substrates for Kinases Involved in the Biosynthesis of Inositol Pyrophosphates and Their Enhancement of ATPase Activity of a Kinase

Molecules, 2021
IP6K and PPIP5K are two kinases involved in the synthesis of inositol pyrophosphates. Synthetic analogs or mimics are necessary to understand the substrate specificity of these enzymes and to find molecules that can alter inositol pyrophosphate synthesis.
Raja Mohanrao, Ruth Manorama, Shubhra Ganguli, Mithun C. Madhusudhanan, Rashna Bhandari, Kana M. Sureshan   +5 more
doaj   +1 more source

Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP₇ metabolism in the enteric nervous system. [PDF]

J Biol Chem, 2023
Ito M, Fujii N, Kohara S, Hori S, Tanaka M, Wittwer C, Kikuchi K, Iijima T, Kakimoto Y, Hirabayashi K, Kurotaki D, Jessen HJ, Saiardi A, Nagata E.   +13 more
europepmc   +2 more sources

Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Epigenetic modifications of chromatin are emerging as important regulatory mechanisms of many nuclear processes. Numerous proteins have been identified that mediate these modifications in a dynamic manner.
Adam Burton, Cristina Azevedo, Catia Andreassi, Braulio Martinez De La Cruz, Adolfo Saiardi   +4 more
openalex   +3 more sources

Interaction with IP6K1 supports pyrophosphorylation of substrate proteins by the inositol pyrophosphate 5-InsP7. [PDF]

Biosci Rep
Inositol pyrophosphates (PP-InsPs) are a sub-family of water soluble inositol phosphates that possess one or more diphosphate groups. PP-InsPs can transfer their β-phosphate group to a phosphorylated Ser residue to generate pyrophosphorylated Ser.
Hamid A, Ladke JS, Shah A, Ganguli S, Pal M, Singh A, Bhandari R.   +6 more
europepmc   +2 more sources

Inositol pyrophosphates regulate endocytic trafficking [PDF]

Proceedings of the National Academy of Sciences, 2002
The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established.
Adolfo, Saiardi, Catherine, Sciambi, J Michael, McCaffery, Beverly, Wendland, Solomon H, Snyder   +4 more
openaire   +2 more sources