Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene Expression. [PDF]
mBio, 2022 Expression of the fission yeast phosphate regulon is sensitive to the intracellular level of the inositol pyrophosphate (IPP) signaling molecule 1,5-IP8.
Benjamin B +5 more
europepmc +2 more sources
Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8. [PDF]
Cell RepLi X +8 more
europepmc +2 more sources
Molecular Brain, 2020 Inositol phosphate metabolism has emerged as one of the key players in synaptic transmission. Previous studies have shown that the deletion of inositol hexakisphosphate kinase 1 (IP6K1), which is responsible for inositol pyrophosphate biosynthesis ...
Min-Gyu Kim +5 more
doaj +1 more source
Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity. [PDF]
PLoS ONE, 2017 Inositol pyrophosphates have been implicated in a wide range of cellular processes. Inositol hexakisphosphate kinase 1 catalyzes the pyrophosphorylation of inositol hexakisphosphate into inositol 5-diphospho-1,2,3,4,6-pentakisphosphate which is important
Michael Wormald +4 more
doaj +1 more source
Scalable Chemoenzymatic Synthesis of Inositol Pyrophosphates [PDF]
Biochemistry, 2019 The inositol pyrophosphates (PP-InsPs) are an important group of cellular messengers that influence a broad range of biological processes. To elucidate the functions of these high-energy metabolites at the biochemical level, access to the purified molecules is required.
Robert Puschmann +2 more
openaire +2 more sources
The Role of Inositol Hexakisphosphate Kinase in the Central Nervous System
Biomolecules, 2023 Inositol is a unique biological small molecule that can be phosphorylated or even further pyrophosphorylated on each of its six hydroxyl groups. These numerous phosphorylation states of inositol along with the kinases and phosphatases that interconvert ...
Tyler Heitmann, James C. Barrow
doaj +1 more source
Versatile signaling mechanisms of inositol pyrophosphates
Current Opinion in Chemical Biology, 2022 Inositol pyrophosphates (PP-InsPs) constitute a group of highly charged messengers, which regulate central biological processes in health and disease, such as cellular phosphate and general energy homeostasis. Deciphering the molecular mechanisms underlying PP-InsP-mediated signaling remains a challenge due to the unique properties of these molecules ...
Minh Nguyen Trung +2 more
openaire +2 more sources
Structural insight into inositol pyrophosphate turnover [PDF]
Advances in Biological Regulation, 2013 The diphosphoinositol polyphosphates ("inositol pyrophosphates"; PP-InsPs) regulate many cellular processes in eukaryotes, including stress responses, apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, telomere maintenance, insulin signaling and neutrophil activation.
Stephen B, Shears +2 more
openaire +2 more sources
Affinity enrichment and identification of inositol poly- and pyrophosphate interactomes
STAR Protocols, 2021 Summary: This protocol describes an affinity enrichment approach from mammalian cell extracts to identify protein binding partners of inositol hexakisphosphate (InsP6) and 5-diphosphoinositol pentakisphosphate (5PP-InsP5), two important eukaryotic ...
David Furkert +2 more
doaj +1 more source
Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease [PDF]
, 2016 Maintenance of electric potential and synaptic transmission are energetically demanding tasks that neuronal metabolism must continually satisfy. Inability to fulfil these energy requirements leads to the development of neurodegenerative disorders ...
Bruni, AC +6 more
core +1 more source