Results 61 to 70 of about 98,783 (245)

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase is a distant IPK member with a singular inositide binding site for axial 2-OH recognition [PDF]

, 2010
Inositol phosphates (InsPs) are signaling molecules with multiple roles in cells. In particular Graphic (InsP6) is involved in mRNA export and editing or chromatin remodeling among other events.
Agarwal, B. Gonzalez, BOZSIK, C. A. Brearley, Caddick, Caddick, Cheek, Collaborative Computational Project Number, Cowtan, Gonz  lez, Graf, Hanakahi, Irvine, J. I. Banos-Sanz, J. Sanz-Aparicio, M. Villate, Maffucci, Messenguy, Michell, Miller, Miller, Mulugu, Murphy, Murshudov, Nolen, Phillippy, Raboy, Raboy, Rowan, Sarmah, Shamsuddin, Sheldrick, Shukla, Sweetman, Vonrhein, York   +35 more
core   +2 more sources

Pathway of phytate dephosphorylation by β-propeller phytases of different origins [PDF]

, 2007
Using a combination of high-performance ion chromatography analysis and kinetic studies, the pathway of myo-inositol hexakisphosphate dephosphorylation by the P-propeller phytase of Shewanella oneidensis was established, which was then compared with that
Carlsson, NG, Cheng, C, Greiner, R, Lim, BL   +3 more
core   +1 more source

Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.

PLoS Pathogens, 2014
The pattern recognition receptor RIG-I is critical for Type-I interferon production. However, the global regulation of RIG-I signaling is only partially understood. Using a human genome-wide RNAi-screen, we identified 226 novel regulatory proteins of RIG-
Niyas Kudukkil Pulloor, Sajith Nair, Kathleen McCaffrey, Aleksandar D Kostic, Pradeep Bist, Jeremy D Weaver, Andrew M Riley, Richa Tyagi, Pradeep D Uchil, John D York, Solomon H Snyder, Adolfo García-Sastre, Barry V L Potter, Rongtuan Lin, Stephen B Shears, Ramnik J Xavier, Manoj N Krishnan   +16 more
doaj   +1 more source

The IP6K Inhibitor LI-2242 Ameliorates Diet-Induced Obesity, Hyperglycemia, and Hepatic Steatosis in Mice by Improving Cell Metabolism and Insulin Signaling

Biomolecules, 2023
Obesity and nonalcoholic fatty liver disease (NAFLD) are global health concerns, and thus, drugs for the long-term treatment of these diseases are urgently needed.
Sandip Mukherjee, Molee Chakraborty, Jake Haubner, Glen Ernst, Michael DePasquale, Danielle Carpenter, James C. Barrow, Anutosh Chakraborty   +7 more
doaj   +1 more source

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes [PDF]

, 2014
Type 2 diabetes is a metabolic disease categorized primarily by reduced insulin sensitivity, β-cell dysfunction, and elevated hepatic glucose production.
Elliott, B.T., Elliott, B.T., Mackenzie, R.W.A., Mackenzie, R.W.A.   +3 more
core   +4 more sources

Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?

Plants, 2020
Inositol pyrophosphates (PP-InsPs) are an emerging class of “high-energy” intracellular signaling molecules, containing one or two diphosphate groups attached to an inositol ring, that are connected with phosphate sensing, jasmonate signaling,
Catherine Freed, Olusegun Adepoju, Glenda Gillaspy   +2 more
doaj   +1 more source

Determination of phytic acid in urine by inductively coupled plasma mass spectrometry [PDF]

, 2005
The aim of this work is to provide a simple and accurate analytical procedure to easily determine phytic acid in urine, in contrast with time-consuming current ...
Muñoz Martínez, José Antonio, Valiente Malmagro, Manuel   +1 more
core   +1 more source

The yeast P5 type ATPase, Spf1, regulates manganese transport into the endoplasmic reticulum [PDF]

, 2013
The endoplasmic reticulum (ER) is a large, multifunctional and essential organelle. Despite intense research, the function of more than a third of ER proteins remains unknown even in the well-studied model organism Saccharomyces cerevisiae.
A Chesi, A Samali, A Szkopińska, AB Bowman, AD Gitler, AH Futerman, Alaa Abdul-Sada, Anthony H. Futerman, AR Reddi, C Janke, C Onyewu, C Suzuki, C Suzuki, CB Brachmann, CC Paulusma, CD Davis, D Berchtold, D Lockshon, D Mandal, D Sorger, DJ Tipper, DK Breslow, E Losev, E Papanikou, E Sammels, E Wiederhold, EH Hettema, F Sherman, Fischl, Frances M. Platt, G Giaever, GA Castillon, GA Castillon, Giuseppe Condomitti, GK Voeltz, GR Corradi, H Yoshida, Howard Riezman, I Braakman, Isabelle Riezman, J Ko, J Meldolesi, J Shima, JA Sullivan, JK Pittman, JM De Freitas, K Araki, K Krumpe, KB Axelsen, LJ Wuestehube, LS Weingarten, LT Jensen, M Fujita, M Fujita, M Fujita, M North, M Schuldiner, M Schuldiner, Maya Schuldiner, MC Jonikas, MS Bae-Lee, Márton Megyeri, N Rimon, Nitzan Rimon, NP Mira, Oscar C. W. Chen, P Estrada de Martin, P Fagone, PJ Schultheis, PL Pedersen, RC Dickson, RC Dickson, RD Gietz, S Ichikawa, S Vashist, S-X Tan, SA Heidler, SC Dos Santos, SL Hansen, SR Cronin, SR Cronin, Stephen W. Michnick, TP Levine, U Loizides-Mangold, Ursula Loizides-Mangold, V Cerantola, V V Kushnirov, VC Culotta, W Kühlbrandt, X Tang, X Zhou, XF Liu, XL Guan, Y Chen, YD Lobsanov, Yifat Cohen   +95 more
core   +7 more sources

Phosphorus distribution in soils from Australian dairy and beef rearing pastoral systems [PDF]

, 2016
The influence of soil type and management practices on P distribution in soils from Australian dairy and beef rearing pastoral systems has been investigated by chemical measurements and phosphorus-31 (31P) nuclear magnetic resonance (NMR) spectroscopy ...
Adeloju, Samuel B., Smernik, Ronald, Webb, Benjamin, Webb, Benjamin   +3 more
core   +3 more sources

Inositol Pyrophosphates as Mammalian Cell Signals [PDF]

Science Signaling, 2011
Identification and knockout of their biosynthetic enzymes has shed light on the diverse functions of the inositol pyrophosphates.
Chakraborty, A Chakraborty, Anutosh, Kim, S Kim, Seyun, Snyder, SH Snyder, Solomon H.   +2 more
openaire   +2 more sources