Acclimation responses of Arabidopsis thaliana to sustained phosphite treatments [PDF]
, 2013 Phosphite () induces a range of physiological and developmental responses in plants by disturbing the homeostasis of the macronutrient phosphate. Because of its close structural resemblance to phosphate, phosphite impairs the sensing, membrane transport,
Berkowitz, O. +7 more
core +2 more sources
Protein pyrophosphorylation: moving forward [PDF]
, 2016 Genetic ablation of inositol pyrophosphate synthesis has established the fundamental importance of this class of molecules to the eukaryote cell. These studies, however, must be complemented by cell biology and biochemical approaches to appreciate the ...
Saiardi, A
core +3 more sources
Molecular Metabolism, 2016 Objective: Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration.
Sarbani Ghoshal +10 more
doaj +1 more source
Metabolic engineering of micronutrients in crop plants [PDF]
, 2016 Micronutrient deficiency is a widespread phenomenon, most prevalent in developing countries. Being causally linked to the occurrence of a range of diseases, it affects billions of people worldwide. Enhancing the content of micronutrients in crop products
Blancquaert, Dieter +3 more
core +2 more sources
Inositol pyrophosphates modulate hydrogen peroxide signalling
Biochemical Journal, 2009 Inositol pyrophosphates are involved in a variety of cellular functions, but the specific pathways and/or downstream targets remain poorly characterized. In the present study we use Saccharomyces cerevisiae mutants to examine the potential roles of inositol pyrophosphates in responding to cell damage caused by ROS (reactive oxygen species).
Onnebo, Sara Maria Nancy +1 more
openaire +3 more sources
Two inositol hexakisphosphate kinases drive inositol pyrophosphate synthesis in plants [PDF]
The Plant Journal, 2014 SummaryInositol pyrophosphates are unique cellular signaling molecules with recently discovered roles in energy sensing and metabolism. Studies in eukaryotes have revealed that these compounds have a rapid turnover, and thus only small amounts accumulate.
Mintu, Desai +9 more
openaire +2 more sources
Inositol pyrophosphates: Why so many phosphates? [PDF]
Advances in Biological Regulation, 2015 The inositol pyrophosphates (PP-InsPs) are a specialized group of "energetic" signaling molecules found in yeasts, plants and animals. PP-InsPs boast the most crowded three dimensional phosphate arrays found in Nature; multiple phosphates and diphosphates are crammed around the six-carbon, inositol ring.
openaire +2 more sources
The Vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungi. [PDF]
PLoS Genetics, 2014 Microtubules (MTs) are pivotal for numerous eukaryotic processes ranging from cellular morphogenesis, chromosome segregation to intracellular transport. Execution of these tasks requires intricate regulation of MT dynamics.
Jennifer Pöhlmann +11 more
doaj +1 more source
Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication [PDF]
, 2019 Summary: HIV-1 hijacks host proteins to promote infection. Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP6) for viral production and primary cell replication.
Böcking, Till +10 more
core +3 more sources
A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine [PDF]
Open Biology, 2015 Inositol phosphates are a large and diverse family of signalling molecules. While genetic studies have discovered important functions for them, the biochemistry behind these roles is often not fully characterized.
Miranda S. C. Wilson +4 more
doaj +1 more source