Results 71 to 80 of about 12,071 (167)

Protein Glycosylation Patterns Shaped by the IRE1‐XBP1s Arm of the Unfolded Protein Response

Israel Journal of Chemistry, Volume 64, Issue 12, December 2024.
Abstract The unfolded protein response (UPR) is a sensing and signaling pathway that surveys the endoplasmic reticulum (ER) for protein folding challenges and responds whenever issues are detected. UPR activation leads to upregulation of secretory pathway chaperones and quality control factors, as well as reduces the nascent protein load on the ER ...
Kenny Chen, Matthew D. Shoulders
wiley   +1 more source

Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes [PDF]

Advances in Enzyme Regulation, 2010
Inositol phosphates and inositol pyrophosphates are small molecule metabolites that play important roles in nuclear processes such as transcription control, mRNA export and DNA repair. On this wonderful occasion of the fiftieth anniversary of the Advances in Enzyme Regulation conference, it is a privilege to participate through presenting recent ...
John D. York, Marco M. Tsui
openaire   +3 more sources

The phosphate starvation response regulator PHR2 antagonizes arbuscule maintenance in Medicago

New Phytologist, Volume 244, Issue 5, Page 1979-1993, December 2024.
Summary Phosphate starvation response (PHR) transcription factors play essential roles in regulating phosphate uptake in plants through binding to the P1BS cis‐element in the promoter of phosphate starvation response genes. Recently, PHRs were also shown to positively regulate arbuscular mycorrhizal colonization in rice and lotus by controlling the ...
Peng Wang, Yanan Zhong, Yan Li, Wenqian Zhu, Yuexuan Zhang, Jingyang Li, Zuohong Chen, Erik Limpens   +7 more
wiley   +1 more source

Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Epigenetic modifications of chromatin are emerging as important regulatory mechanisms of many nuclear processes. Numerous proteins have been identified that mediate these modifications in a dynamic manner. However, less is known about the signaling pathways that transduce upstream signals into chromatin changes. Here,
Antonella Riccio, Antonella Riccio, Catia Andreassi, Catia Andreassi, Adolfo Saiardi, Cristina Azevedo, Adam Burton   +6 more
openaire   +3 more sources

Resin acid δ13C and δ18O as indicators of intra‐seasonal physiological and environmental variability

Plant, Cell &Environment, Volume 47, Issue 12, Page 5411-5423, December 2024.
Abstract Understanding the dynamics of δ13C and δ18O in modern resin is crucial for interpreting (sub)fossilized resin records and resin production dynamics. We measured the δ13C and δ18O offsets between resin acids and their precursor molecules in the top‐canopy twigs and breast‐height stems of mature Pinus sylvestris trees.
Yu Tang, Elina Sahlstedt, Kaisa Rissanen, Jaana Bäck, Pauliina Schiestl‐Aalto, Charlotte Angove, Andreas Richter, Matthias Saurer, Juho Aalto, Paulina Dukat, Anna Lintunen, Katja T. Rinne‐Garmston   +11 more
wiley   +1 more source

Inositol Pyrophosphates as Versatile Metabolic Messengers

Annual Review of Biochemistry
Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling metabolites whose versatile modes of action are being increasingly appreciated. These include their emerging roles as energy regulators, phosphodonors, steric/allosteric regulators, and G protein–coupled receptor messengers.
Latika, Nagpal, Sining, He, Feng, Rao, Solomon H, Snyder   +3 more
openaire   +2 more sources

Microbial Squalene: A Sustainable Alternative for the Cosmetics and Pharmaceutical Industry – A Review

Engineering in Life Sciences, Volume 24, Issue 10, October 2024.
ABSTRACT Squalene is a natural triterpenoid and a biosynthetic precursor of steroids and hopanoids in microorganisms, plants, humans, and other animals. Squalene has exceptional properties, such as its antioxidant activity, a high penetrability of the skin, and the ability to trigger the immune system, promoting its application in the cosmetic ...
Saseendran Shalu, Panam Kunnel Raveendranathan Karthikanath, Vinoth Kumar Vaidyanathan, Lars M. Blank, Andrea Germer, Palanisamy Athiyaman Balakumaran   +5 more
wiley   +1 more source

Inositol biosynthesis is fine‐tuned by inositol pyrophosphates in Saccharomyces cerevisiae

The FASEB Journal, 2013
In yeast, inositol biosynthesis is coordinated with the synthesis of phospholipids by controlling the expression of enzymes in the biosynthetic pathways. Inositol pyrophosphates, most recently characterized in the inositide family, have diverse roles in phosphate signaling and other important cellular processes.
Miriam L. Greenberg, Cunqi Ye
openaire   +1 more source

Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? [PDF]

, 2003
The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Clapp, LH, Cui, Y, Giblin, JP, Quinn, KV, Tinker, A   +4 more
core   +1 more source

Calcium‐dependent antimicrobials: Nature‐inspired materials and designs

Exploration, Volume 4, Issue 5, October 2024.
The paper summarizes calcium's merits in coordination, hydration, ionization, and stereochemistry for acting as a structural former or trigger in biological systems, illuminates its natural roles in pathogens and the immune systems, and discusses its applications in infection medications.
Zhong Wang, Yongjie Zeng, Zubair Ahmed, Hui Qin, Ijaz Ahmad Bhatti, Huiliang Cao   +5 more
wiley   +1 more source