Results 81 to 90 of about 98,783 (245)
Role of the inositol pyrophosphate multikinase Kcs1 in Cryptococcus inositol metabolism. [PDF]
Fungal Genet Biol, 2018 Cryptococcus neoformans is the most common cause of deadly fungal meningitis. This fungus has a complex inositol acquisition and utilization system, and our previous studies have shown the importance of inositol utilization in cryptococcal development and virulence. However, how inositol utilization is regulated in this fungus remains unknown.
Liao G +7 more
europepmc +4 more sources
Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? [PDF]
, 2003 The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Clapp, LH +4 more
core +1 more source
Inositol pyrophosphates and their unique metabolic complexity: analysis by gel electrophoresis.
PLoS ONE, 2009 BackgroundInositol pyrophosphates are a recently characterized cell signalling molecules responsible for the pyrophosphorylation of protein substrates. Though likely involved in a wide range of cellular functions, the study of inositol pyrophosphates has
Oriana Losito +3 more
doaj +1 more source
bioRxiv, 2023 Inositol pyrophosphates (PP-IPs) are a sub-family of water soluble inositol phosphates that possess one or more diphosphate groups. PP-IPs can transfer their β-phosphate group to a phosphorylated Ser residue to generate pyrophosphorylated Ser.
Aisha Hamid +6 more
semanticscholar +1 more source
A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors. [PDF]
PLoS ONE, 2016 Pharmacological tools-'chemical probes'-that intervene in cell signaling cascades are important for complementing genetically-based experimental approaches.
Brandi M Baughman +8 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 Phosphate and calcium ions are nutrients that play key roles in growth, differentiation and the production of bioactive secondary metabolites in filamentous fungi. Phosphate concentration regulates the biosynthesis of hundreds of fungal metabolites.
Juan F. Martín
doaj +1 more source
The inositol pyrophosphate pathway in health and diseases. [PDF]
Biol Rev Camb Philos Soc, 2018 ABSTRACTInositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds and fungi to mammals. Distinct classes of kinases generate different forms of energetic diphosphate‐containing IPPs from inositol phosphates (IPs). Conversely, polyphosphate phosphohydrolase enzymes dephosphorylate IPPs to regenerate the respective IPs ...
Chakraborty A.
europepmc +4 more sources
Has Inositol Played Any Role in the Origin of Life? [PDF]
, 2017 Phosphorus, as phosphate, plays a paramount role in biology. Since phosphate transfer reactions are an integral part of contemporary life, phosphate may have been incorporated into the initial molecules at the very beginning.
Saiardi, A
core +1 more source
Potential Phosphorus Uptake Mechanisms in the Deep Sedimentary Biosphere
Frontiers in Marine Science, 2022 Our understanding of phosphorus (P) dynamics in the deep subseafloor environment remains limited. Here we investigate potential microbial P uptake mechanisms in oligotrophic marine sediments beneath the North Atlantic Gyre and their effects on the ...
Delphine Defforey +8 more
doaj +1 more source
Arabidopsis PFA-DSP-Type Phosphohydrolases Target Specific Inositol Pyrophosphate Messengers
bioRxiv, 2022 Inositol pyrophosphates are signaling molecules containing at least one phosphoanhydride bond that regulate a wide range of cellular processes in eukaryotes.
Philipp Gaugler +17 more
semanticscholar +1 more source