Results 1 to 10 of about 428,561 (236)

The integrated stress response in neurodegenerative diseases. [PDF]

Mol Neurodegener
The integrated stress response (ISR) is a conserved network in eukaryotic cells that mediates adaptive responses to diverse stressors. The ISR pathway ensures cell survival and homeostasis by regulating protein synthesis in response to internal or ...
Bravo-Jimenez MA, Sharma S, Karimi-Abdolrezaee S.   +2 more
europepmc   +5 more sources

PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response. [PDF]

Elife
Mitochondrial dysfunction is involved in numerous diseases and the aging process. The integrated stress response (ISR) serves as a critical adaptation mechanism to a variety of stresses, including those originating from mitochondria.
Cheng L, Meliala I, Kong Y, Chen J, Proud CG, Björklund M.   +5 more
europepmc   +4 more sources

Integrated Stress Response (ISR) Modulators in Vascular Diseases. [PDF]

Cells
Vascular dysfunction lies at the core of cardiovascular diseases—the leading cause of global morbidity and mortality. Despite their prevalence, therapeutic options remain limited, in part due to an incomplete understanding of the molecular mechanisms ...
Kalinin A, Zubkova E, Beloglazova I, Parfyonova Y, Menshikov M.   +4 more
europepmc   +2 more sources

The emerging role and therapeutic implications of bacterial and parasitic deubiquitinating enzymes

Frontiers in Immunology, 2023
Deubiquitinating enzymes (DUBs) are emerging as key factors for the infection of human cells by pathogens such as bacteria and parasites. In this review, we discuss the most recent studies on the role of deubiquitinase activity in exploiting and ...
Markus Wehrmann, Markus Wehrmann, David Vilchez, David Vilchez, David Vilchez, David Vilchez   +5 more
doaj   +1 more source

Advanced Pathogenetic Concepts in T-Cell Prolymphocytic Leukemia and Their Translational Impact

Frontiers in Oncology, 2021
T-cell prolymphocytic leukemia (T-PLL) is the most common mature T-cell leukemia. It is a typically aggressively growing and chemotherapy-resistant malignancy with a poor prognosis.
Till Braun, Annika Dechow, Gregor Friedrich, Michael Seifert, Johanna Stachelscheid, Marco Herling, Marco Herling   +6 more
doaj   +1 more source

Cigarette Smoke Extract Activates Hypoxia-Inducible Factors in a Reactive Oxygen Species-Dependent Manner in Stroma Cells from Human Endometrium

Antioxidants, 2021
Cigarette smoking (CS) is a major contributing factor in the development of a large number of fatal and debilitating disorders, including degenerative diseases and cancers.
Naoko Kida, Yoshiyuki Matsuo, Yoshiko Hashimoto, Kenichiro Nishi, Tomoko Tsuzuki-Nakao, Hidemasa Bono, Tetsuo Maruyama, Kiichi Hirota, Hidetaka Okada   +8 more
doaj   +1 more source

Involvement of Integrated Stress Response in Drug-Induced Secondary Dystonia. [PDF]

ACS Omega
Simon TA, Parise SB, Jackson NE, Patel RC.   +3 more
europepmc   +2 more sources

Research progress of integrated stress response in pathogenesis of Alzheimer's disease

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Integrated stress response (ISR) is a cellular adaptive response induced by stress, which is strictly regulated by multiple phosphokinases, phosphatases and other proteins to maintain protein homeostasis.
SUN Hui, JIN Hongfu, GUO Shenrui, FENG Yiyuan, YIN Yafu, WANG Hui, CHENG Weiwei   +6 more
doaj   +1 more source

Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal

Scientific Reports, 2021
Since understanding molecular mechanisms of SARS-CoV-2 infection is extremely important for developing effective therapies against COVID-19, we focused on the internalization mechanism of SARS-CoV-2 via ACE2.
Keiji Tanimoto, Kiichi Hirota, Takahiro Fukazawa, Yoshiyuki Matsuo, Toshihito Nomura, Nazmul Tanuza, Nobuyuki Hirohashi, Hidemasa Bono, Takemasa Sakaguchi   +8 more
doaj   +1 more source

Micro-RNA networks in T-cell prolymphocytic leukemia reflect T-cell activation and shape DNA damage response and survival pathways

Haematologica, 2020
T-cell prolymphocytic leukemia (T-PLL) is a poor-prognostic mature T-cell malignancy. It typically presents with exponentially rising lymphocyte counts, splenomegaly, and bone marrow infiltration.
Till Braun, Markus Glass, Linus Wahnschaffe, Moritz Otte, Petra Mayer, Marek Franitza, Janine Altmüller, Michael Hallek, Stefan Hüttelmaier, Alexandra Schrader, Marco Herling   +10 more
doaj   +1 more source