Results 11 to 20 of about 428,561 (236)

Signaling plasticity in the integrated stress response

Frontiers in Cell and Developmental Biology, 2023
The Integrated Stress Response (ISR) is an essential homeostatic signaling network that controls the cell’s biosynthetic capacity. Four ISR sensor kinases detect multiple stressors and relay this information to downstream effectors by phosphorylating a ...
Morgane Boone, Francesca Zappa
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The integrated stress response in pulmonary disease [PDF]

European Respiratory Review, 2020
The respiratory tract and its resident immune cells face daily exposure to stress, both from without and from within. Inhaled pathogens, including severe acute respiratory syndrome coronavirus 2, and toxins from pollution trigger a cellular defence ...
Giulia Emanuelli, Nikou Nassehzadeh-Tabriz, Nick W. Morrell, Stefan J. Marciniak   +3 more
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Targeting the Integrated Stress Response in Cancer Therapy [PDF]

Frontiers in Pharmacology, 2021
The integrated stress response (ISR) is an evolutionarily conserved intra-cellular signaling network which is activated in response to intrinsic and extrinsic stresses.
Xiaobing Tian, Xiaobing Tian, Xiaobing Tian, Xiaobing Tian, Shengliang Zhang, Shengliang Zhang, Shengliang Zhang, Shengliang Zhang, Lanlan Zhou, Lanlan Zhou, Lanlan Zhou, Lanlan Zhou, Attila A. Seyhan, Attila A. Seyhan, Attila A. Seyhan, Attila A. Seyhan, Liz Hernandez Borrero, Yiqun Zhang, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry, Wafik S. El-Deiry   +22 more
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Targeting the integrated stress response in hematologic malignancies

Experimental Hematology & Oncology, 2022
While numerous targeted therapies have been recently adopted to improve the treatment of hematologic malignancies, acquired or intrinsic resistance poses a significant obstacle to their efficacy.
Gus O. Nwosu, Jason A. Powell, Stuart M. Pitson   +2 more
doaj   +5 more sources

Integrated stress response restricts macrophage necroptosis [PDF]

Life Science Alliance, 2021
The integrated stress response (ISR) regulates cellular homeostasis and cell survival following exposure to stressors. Cell death processes such as apoptosis and pyroptosis are known to be modulated by stress responses, but the role of the ISR in necroptosis is poorly understood.
David E Place, Parimal Samir, RK Subbarao Malireddi, Thirumala-Devi Kanneganti   +3 more
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Targeting the integrated stress response in ophthalmology [PDF]

Current Eye Research, 2021
Purpose: To summarize the Integrated Stress Response (ISR) in the context of ophthalmology, with special interest on the cornea and anterior segment. Results: The ISR is a powerful and conserved signaling pathway that allows for cells to respond to a diverse array of both intracellular and extracellular stressors. The pathway is classically responsible
Hsiao-Sang Chu (548628), Cornelia Peterson (10015772), Albert Jun (10015775), James Foster (59241)   +3 more
openaire   +3 more sources

The integrated stress response [PDF]

EMBO reports, 2016
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2¿) by one of four members of the eIF2¿ kinase family, which leads to a ...
Karolina Pakos‐Zebrucka, Izabela Koryga, Katarzyna Mnich, Mila Ljujic, Afshin Samali, Adrienne M Gorman   +5 more
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Integrated stress responses in Salmonella [PDF]

International Journal of Food Microbiology, 2012
The foodborne gram-negative pathogen Salmonella must adapt to varied environmental conditions encountered within foods, the host gastrointestinal tract and the phagosomes of host macrophages. Adaptation is achieved through the coordinate regulation of gene expression in response to environmental signals such as temperature, pH, osmolarity, redox state,
Shu, Shen, Ferric C, Fang
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Autophagy and the Integrated Stress Response [PDF]

Molecular Cell, 2010
Autophagy is a tightly regulated pathway involving the lysosomal degradation of cytoplasmic organelles or cytosolic components. This pathway can be stimulated by multiple forms of cellular stress, including nutrient or growth factor deprivation, hypoxia, reactive oxygen species, DNA damage, protein aggregates, damaged organelles, or intracellular ...
Kroemer, Guido, Mariño, Guillermo, Levine, Beth   +2 more
openaire   +2 more sources

Salubrinal Enhances Cancer Cell Death during Glucose Deprivation through the Upregulation of xCT and Mitochondrial Oxidative Stress

Biomedicines, 2021
Cancer cells have the metabolic flexibility to adapt to heterogeneous tumor microenvironments. The integrated stress response (ISR) regulates the cellular adaptation response during nutrient stress.
Mei-Chun Chen, Li-Lin Hsu, Sheng-Fan Wang, Yi-Ling Pan, Jeng-Fan Lo, Tien-Shun Yeh, Ling-Ming Tseng, Hsin-Chen Lee   +7 more
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