Results 21 to 30 of about 428,561 (236)

A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response

Frontiers in Molecular Neuroscience, 2023
ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the integrated stress response. The integrated stress response is triggered by phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 complex ...
Graham Neill, Glenn R. Masson
doaj   +1 more source

The Integrated Stress Response in Lung Disease [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2014
Lungs are repeatedly exposed to inhaled toxic insults, such as smoke, diesel exhaust, and microbes, which elicit cellular stress responses. The phosphorylation of eukaryotic translation initiation factor 2α by one of four stress-sensing kinases triggers a pathway called the integrated stress response that helps protect cellular reserves of nutrients ...
Wout, E.F.A. van 't, Hiemstra, P.S., Marciniak, S.J.   +2 more
openaire   +3 more sources

CCR7 as a novel therapeutic target in t-cell PROLYMPHOCYTIC leukemia

Biomarker Research, 2020
T-cell prolymphocytic leukemia (T-PLL) is a poor prognostic disease with very limited options of efficient therapies. Most patients are refractory to chemotherapies and despite high response rates after alemtuzumab, virtually all patients relapse ...
Carlos Cuesta-Mateos, Patricia Fuentes, Alexandra Schrader, Raquel Juárez-Sánchez, Javier Loscertales, Tamara Mateu-Albero, Lorena Vega-Piris, Marina Espartero-Santos, Ana Marcos-Jimenez, Blanca Andrea Sánchez-López, Yaiza Pérez-García, Dennis Jungherz, Sebastian Oberbeck, Linus Wahnschaffe, Anna Kreutzman, Emma I. Andersson, Satu Mustjoki, Edgar Faber, Ana Urzainqui, Manuel Fresno, Kostantino Stamatakis, Arantzazu Alfranca, Fernando Terrón, Marco Herling, María Luisa Toribio, Cecilia Muñoz-Calleja   +25 more
doaj   +1 more source

The integrated stress response promotes B7H6 expression [PDF]

Journal of Molecular Medicine, 2019
Abstract The B7 family member, B7H6, is a ligand for the natural killer cell receptor NKp30. B7H6 is hardly expressed on normal tissues, but undergoes upregulation on different types of tumors, implicating it as an attractive target for cancer immunotherapy. The molecular mechanisms that control B7H6 expression are poorly understood. We report that in
Obiedat, Akram, Charpak-Amikam, Yoav, Tai-Schmiedel, Julie, Seidel, Einat, Mahameed, Mohamed, Avril, Tony, Stern-Ginossar, Noam, Springuel, Lorraine, Bolsée, Jennifer, Gilham, David E, Dipta, Priya, Shmuel, Miriam, Chevet, Eric, Mandelboim, Ofer, Tirosh, Boaz   +14 more
openaire   +3 more sources

Plasticity of the mammalian integrated stress response. [PDF]

Nature
An increased level of phosphorylation of eukaryotic translation initiation factor 2 subunit-α (eIF2α, encoded by EIF2S1; eIF2α-p) coupled with decreased guanine nucleotide exchange activity of eIF2B is a hallmark of the 'canonical' integrated stress response (c-ISR)1.
Chen CW, Papadopoli D, Szkop KJ, Guan BJ, Alzahrani M, Wu J, Jobava R, Asraf MM, Krokowski D, Vourekas A, Merrick WC, Komar AA, Koromilas AE, Gorospe M, Payea MJ, Wang F, Clayton BLL, Tesar PJ, Schaffer A, Miron A, Bederman I, Jankowsky E, Vogel C, Valášek LS, Dinman JD, Zhang Y, Tirosh B, Larsson O, Topisirovic I, Hatzoglou M.   +29 more
europepmc   +4 more sources

Integrated Endoplasmic Reticulum Stress Responses in Cancer [PDF]

Cancer Research, 2007
Abstract The endoplasmic reticulum (ER) has emerged as a major site of cellular homeostasis regulation, particularly in the unfolded protein response, which is being found to play a major role in cancer and many other diseases. Here, we address ER-mediated signaling and regulations in the context of environmental challenges in cancer ...
Michel, Moenner, Olivier, Pluquet, Marion, Bouchecareilh, Eric, Chevet   +3 more
openaire   +2 more sources

Termination of the integrated stress response. [PDF]

Science
Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by phosphorylation of translation initiation factor eIF2, which traps and inhibits rate-limiting translation factor eIF2B thereby attenuating translation ...
De Miguel C, Thorkelsson SR, Fatalska A, Hodgson G, Dalglish M, Wang C, Bertolotti A.   +6 more
europepmc   +2 more sources

Bisphenol A promotes stress granule assembly and modulates the integrated stress response

Biology Open, 2021
Bisphenol-A (BPA) is a ubiquitous precursor of polycarbonate plastics that is found in the blood and serum of >92% of Americans. While BPA has been well documented to act as a weak estrogen receptor (ER) agonist, its effects on cellular stress are ...
Marta M. Fay, Daniella Columbo, Cecelia Cotter, Chandler Friend, Shawna Henry, Megan Hoppe, Paulina Karabelas, Corbyn Lamy, Miranda Lawell, Sarah Monteith, Christina Noyes, Paige Salerno, Jingyi Wu, Hedan Mindy Zhang, Paul J. Anderson, Nancy Kedersha, Pavel Ivanov, Natalie G. Farny   +17 more
doaj   +1 more source

The integrated stress response in budding yeast lifespan extension

Microbial Cell, 2017
Aging is a complex, multi-factorial biological process shared by all living organisms. It is manifested by a gradual accumulation of molecular alterations that lead to the decline of normal physiological functions in a time-dependent fashion.
Spike D.L. Postnikoff, Jay E. Johnson, Jessica K. Tyler   +2 more
doaj   +1 more source

Transcriptional Control of Metastasis by Integrated Stress Response Signaling

Frontiers in Oncology, 2021
As a central cellular program to sense and transduce stress signals, the integrated stress response (ISR) pathway has been implicated in cancer initiation and progression. Depending on the genetic mutation landscape, cellular context, and differentiation
Si Lu, Si Lu, Li-Xian Yang, Li-Xian Yang, Zi-Jian Cao, Zi-Jian Cao, Jiang-Sha Zhao, Jiang-Sha Zhao, Jia You, Yu-Xiong Feng, Yu-Xiong Feng   +10 more
doaj   +1 more source