Results 31 to 40 of about 428,561 (236)

Innate Immune Recognition, Integrated Stress Response, Infection, and Tumorigenesis

Biology, 2023
Engagement of PRRs in recognition of PAMPs or DAMPs is one of the processes that initiates cellular stress. These sensors are involved in signaling pathways leading to induction of innate immune processes.
Klara Kubelkova, Vanda Bostik, Lokesh Joshi, Ales Macela   +3 more
doaj   +1 more source

Immunogenic cell death triggered by impaired deubiquitination in multiple myeloma relies on dysregulated type I interferon signaling

Frontiers in Immunology, 2023
IntroductionProteasome inhibition is first line therapy in multiple myeloma (MM). The immunological potential of cell death triggered by defects of the ubiquitin-proteasome system (UPS) and subsequent perturbations of protein homeostasis is, however ...
Zeinab Waad Sadiq, Annamaria Brioli, Annamaria Brioli, Ruba Al-Abdulla, Gonca Çetin, Jacqueline Schütt, Hugo Murua Escobar, Elke Krüger, Frédéric Ebstein   +8 more
doaj   +1 more source

Signaling Overlap between the Golgi Stress Response and Cysteine Metabolism in Huntington’s Disease

Antioxidants, 2021
Huntington’s disease (HD) is caused by expansion of polyglutamine repeats in the protein huntingtin, which affects the corpus striatum of the brain. The polyglutamine repeats in mutant huntingtin cause its aggregation and elicit toxicity by affecting ...
Bindu D. Paul
doaj   +1 more source

Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction

mBio, 2023
In response to the host environment, the human pathogen Cryptococcus neoformans must rapidly reprogram its translatome from one which promotes growth to one which is responsive to host stress.
Corey M. Knowles, David Goich, Amanda L. M. Bloom, Murat C. Kalem, John C. Panepinto   +4 more
doaj   +1 more source

ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes

Cell Reports
Summary: The majority of severe early-onset and juvenile cases of amyotrophic lateral sclerosis (ALS) are caused by mutations in the FUS gene, resulting in rapid disease progression.
Hafiza Alirzayeva, Rute Loureiro, Seda Koyuncu, Franziska Hommen, Yara Nabawi, William Hongyu Zhang, Thien T.P. Dao, Markus Wehrmann, Hyun Ju Lee, David Vilchez   +9 more
doaj   +1 more source

eIF2B-capturing viral protein NSs suppresses the integrated stress response

Nature Communications, 2021
Here the authors show that a viral protein interferes with the binding of phosphorylated eIF2 to eIF2B, thereby suppressing the host integrated stress response (ISR). This suppression of the ISR abrogates translational changes of the host and ameliorates
Kazuhiro Kashiwagi, Yuichi Shichino, Tatsuya Osaki, Ayako Sakamoto, Madoka Nishimoto, Mari Takahashi, Mari Mito, Friedemann Weber, Yoshiho Ikeuchi, Shintaro Iwasaki, Takuhiro Ito   +10 more
doaj   +1 more source

Monitoring integrated stress response in liveDrosophila

, 2023
SummaryCells exhibit stress responses to various environmental changes. Among these responses, the integrated stress response (ISR) plays a pivotal role as a crucial stress signaling pathway. While extensive ISR research has been conducted on cultured cells, our understanding of its implications in multicellular organisms remains limited, largely due ...
Peter V. Lidsky, Jing Yuan, Kseniya A. Lashkevich, Sergey E. Dmitriev, Raul Andino   +4 more
openaire   +2 more sources

EIF2α phosphorylation: a hallmark of both autophagy and immunogenic cell death

Molecular & Cellular Oncology, 2020
Different intrinsic and extrinsic stress pathways including endoplasmic reticulum (ER) stress converge on the phosphorylation of eukaryotic translation initiation factor 2A (EIF2A, best known as eIF2α), which characterizes the so-called “integrated ...
Juliette Humeau, Lucillia Bezu, Oliver Kepp, Guido Kroemer   +3 more
doaj   +1 more source

Arsenicals, the Integrated Stress Response, and Epstein–Barr Virus Lytic Gene Expression

Viruses, 2021
Following our observation that clofoctol led to Epstein–Barr virus (EBV) lytic gene expression upon activation of the integrated stress response (ISR), we decided to investigate the impact of As2O3 on viral lytic gene expression.
Jaeyeun Lee, Jennifer Stone, Prashant Desai, John G. Kosowicz, Jun O. Liu, Richard F. Ambinder   +5 more
doaj   +1 more source

Inhibition of the integrated stress response reverses oxidative stress damage-induced postoperative cognitive dysfunction

Frontiers in Cellular Neuroscience, 2022
Postoperative cognitive dysfunction (POCD) is a common complication following anesthesia and surgery that might lead to a decline in learning and memory. Oxidative stress damage is one of the pathogenic mechanisms underlying POCD.
Linhao Jiang, Linhao Jiang, Linhao Jiang, Linhao Jiang, Rui Dong, Rui Dong, Rui Dong, Rui Dong, Minhui Xu, Minhui Xu, Minhui Xu, Yujia Liu, Yujia Liu, Yujia Liu, Yujia Liu, Jiyan Xu, Jiyan Xu, Jiyan Xu, Jiyan Xu, Zhengliang Ma, Tianjiao Xia, Tianjiao Xia, Tianjiao Xia, Xiaoping Gu   +23 more
doaj   +1 more source