Results 91 to 100 of about 10,873 (167)

Mechanistic role of GNE‐987 targeting BRD4‐HCP5 axis in pediatric T‐cell acute lymphoblastic leukemia

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
Abstract This study aims to explore the mechanism of action of the Bromodomain‐containing protein 4 (BRD4) inhibitor GNE‐987 in the treatment of pediatric T‐cell Acute Lymphoblastic Leukemia (T‐ALL), focusing on its effect in inhibiting T‐ALL cell proliferation by activating the HLA Complex P5 (HCP5) Super‐enhancer.
Xu Sang, Mengying Jiang, Yanchun Guan, Xin Chen, Zhen Zhang, Yumeng Wu, Wansheng Peng   +6 more
wiley   +1 more source

Multi‐omic profiling defines three distinct molecular subtypes of urothelial carcinoma with implications for precision therapy

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
We developed three UC clusters, applicable for MIBC and NMIBC, which were validated using transcriptomic- and proteomic datasets. Publically available UC cell lines were assigned to the clusters, to have in vitro models representing each cluster. The clusters differ in molecular and biological signatures, with distinct prognostic and therapeutic ...
Nils C. H. van Creij, Piotr Tymoszuk, Florian Handle, Andreas Seeber, Teresa Sellemond, Agnieszka Martowicz, Eva Comperat, Hamed Wafa, Steffen Ormanns, Michael Günther, Walther Parson, Maxim Noeparast, Frédéric R. Santer, José Daniel Subiela, Petros Grivas, Roger Li, Zoran Culig, Renate Pichler   +17 more
wiley   +1 more source

Existence, Stability, and Data‐Driven Analysis of a Fractional‐Order Avian Influenza Model in Poultry Farms

Engineering Reports, Volume 8, Issue 3, March 2026.
We develop and analyze a fractional‐order avian influenza chicken model for chicken farms, providing existence, uniqueness, and stability results. With real Bangladesh farm data and 80% vaccine efficacy, numerical results show that combining vaccination and treatment can control disease spread by reducing the basic reproduction number below one ...
Muhammad Altaf Khan, Mahmoud H. DarAssi, Irfan Ahmad, Ebraheem Alzahrani, Nurulfiza Mat Isa   +4 more
wiley   +1 more source

Low Dose Pegylated Interferon Alpha as a First‐Line Treatment for Necrobiotic Xanthogranuloma

JEADV Clinical Practice, Volume 5, Issue 1, Page 215-218, March 2026.
ABSTRACT Necrobiotic xanthogranuloma (NXG) is a rare, progressive granulomatous disorder frequently associated with monoclonal gammopathy, particularly monoclonal gammopathy of undetermined significance (MGUS). It typically presents with indurated to ulcerative yellowish plaques or nodules, often with ocular involvement.
Ishana Dixit, Charmaine Vanessa S. Chamberlin, Pablo Fernandez‐Peñas   +2 more
wiley   +1 more source

Bacteriophage Therapy: Current Strategies and Future Perspectives

MedComm, Volume 7, Issue 3, March 2026.
This manuscript systematically reviews the expanding scope of phage applications. It moves beyond traditional antibacterial use to explore their role in precision therapies against drug‐resistant infections, their synergy with antibiotics, and advanced biomaterial‐assisted delivery systems.
Zihe Zhou, Hanyu Fu, Mengzhe Li, Zhongyu Han, Zhenchao Wu, Huahao Fan, Ning Shen, Jiajia Zheng   +7 more
wiley   +1 more source

Non‐Invasive Assessment of Complete Regression in Endometrial Cancer Patients Undergoing Fertility Preservation Using MRI‐Based Radiomics and Immune Heterogeneity

MedComm, Volume 7, Issue 3, March 2026.
Fertility preservation therapy allows young women with early EC to preserve fertility. We developed a non‐invasive MRI radiomics model to predict treatment success. It accurately identifies patients less likely to achieve remission, linking this to an immunosuppressive tumor environment. This aids personalized treatment planning.
Xingchen Li, Kun Shang, Jingyuan Wang, Aoxuan Zhu, Yuman Wu, Yue Qi, Xinyi Bi, Yiqin Wang, Jianliu Wang   +8 more
wiley   +1 more source

Human cytomegalovirus exploits STING signaling and counteracts IFN/ISG induction to facilitate infection of dendritic cells

Nature Communications
Human cytomegalovirus (HCMV) is a widespread pathogen that in immunocompromised hosts can cause life-threatening disease. Studying HCMV-exposed monocyte-derived dendritic cells by single-cell RNA sequencing, we observe that most cells are entered by the ...
Bibiana Costa, Jennifer Becker, Tobias Krammer, Felix Mulenge, Verónica Durán, Andreas Pavlou, Olivia Luise Gern, Xiaojing Chu, Yang Li, Luka Čičin-Šain, Britta Eiz-Vesper, Martin Messerle, Lars Dölken, Antoine-Emmanuel Saliba, Florian Erhard, Ulrich Kalinke   +15 more
doaj   +1 more source

Epigenetic Suppression of Interferon Lambda Receptor Expression Leads to Enhanced Human Norovirus Replication In Vitro

mBio, 2019
Human norovirus (HuNoV) is the main cause of gastroenteritis worldwide, yet no therapeutics are currently available. Here, we utilize a human norovirus replicon in human gastric tumor (HGT) cells to identify host factors involved in promoting or ...
Sabastine E. Arthur, Frédéric Sorgeloos, Myra Hosmillo, Ian G. Goodfellow   +3 more
doaj   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Analysis of the association of influenza clinical course with single nucleotide polymorphisms in genes affecting the interferon-λ3 production

Вопросы вирусологии
Introduction. Predisposition to different courses of the infectious process is largely associated with the polymorphisms in human genome, especially in genes encoding proteins of the immune system.
Lyudmila I. Nikolaeva, Maya D. Stuchinskaya, Kristina P. Telepenina, Nadezhda G. Shevchenko, Victor V. Kuprianov, Kirill G. Krasnoslobodtsev, Evgenya A. Mukasheva, Svetlana V. Trushakova, Irina N. Khlopova, Irina S. Kruzhkova, Lidya B. Kisteneva, Lyudmila V. Kolobukhina, Elena I. Burtseva   +12 more
doaj   +1 more source