Results 41 to 50 of about 10,873 (167)
IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment
EMBO Molecular Medicine, 2016 Influenza A virus (IAV)‐induced severe disease is characterized by infected lung epithelia, robust inflammatory responses and acute lung injury.
Sophia Davidson +7 more
doaj +1 more source
Interferons lambda, new cytokines with antiviral activity
Acta virologica, 2013 Interferons (IFNs) are key cytokines in the establishment of a multifaceted antiviral response. Three distinct types of IFNs are now recognized (type I, type II, and type III) based on their receptor usage, structural features and biological activities.
K, Lopušná +6 more
openaire +3 more sources
PLoS ONE, 2009 BackgroundType-I interferons, type-II interferons, and the IL-10 family are helical cytokines with similar three-dimensional folds. However, their homologous relationship is difficult to detect on the basis of sequence alone. We have previously described
Brian A Fox +2 more
doaj +1 more source
Interferon lambda 1 is associated with dengue severity in Thailand
International Journal of Infectious Diseases, 2020 Objectives: Patients with dengue exhibit a range of symptoms from an acute febrile illness (dengue fever, DF), to dengue hemorrhagic fever (DHF), and to the most severe outcome, dengue shock syndrome (DSS).
Unchana Arayasongsak +8 more
doaj +1 more source
Interferon lambda receptor-1 isoforms differentially influence gene expression and HBV replication in stem cell-derived hepatocytes. [PDF]
Antiviral ResNovotny LA +4 more
europepmc +2 more sources
Frontiers in Immunology, 2022 Granulomas are the hallmark of Mycobacterium tuberculosis (Mtb) infection. Cytokine-mediated signaling can modulate immune function; thus, understanding the cytokine milieu in granulomas is critical for understanding immunity in tuberculosis (TB ...
Priyanka Talukdar +9 more
doaj +1 more source
PLoS ONE, 2014 BackgroundIL28B gene polymorphism is the best baseline predictor of response to interferon alfa-based antiviral therapies in chronic hepatitis C. Recently, a new IFN-L4 polymorphism was identified as first potential functional variant for induction of ...
Simone Susser +8 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen +7 more
wiley +1 more source
Frontiers in Immunology, 2019 Type III interferon-lambda (IFN-λ) plays a critical role against infection, particularly in mucosal infection in the respiratory and gastrointestinal tract.
Liang Li +5 more
doaj +1 more source
Interferon lambda 4 genotype and pathway in alcoholic hepatitis
Scandinavian Journal of Gastroenterology, 2021 Single nucleotide polymorphisms within the interferon lambda 4 (IFNL4) gene influence liver inflammation and fibrosis in chronic liver disease. We investigated whether this is also the case during acute liver disease, alcoholic hepatitis. We, therefore, related variants within the IFNL4 gene to the clinical course of acute alcoholic hepatitis, and ...
Sidsel Støy (286606) +7 more
openaire +4 more sources