Results 1 to 10 of about 548,210 (297)

The role of interleukin-18 and interleukin-18 binding protein in K/BxN serum transfer-induced arthritis [PDF]

Frontiers in Immunology, 2023
BackgroundInterleukin-18 is a proinflammatory cytokine, the activity of which is regulated by its natural inhibitor, IL-18 binding protein (IL-18BP). Elevated circulating levels of IL-18 have been observed in patients with systemic juvenile idiopathic ...
Sebastien Fauteux-Daniel, Sebastien Fauteux-Daniel, Sebastien Fauteux-Daniel, Laura M. Merlo Pich, Laura M. Merlo Pich, Laura M. Merlo Pich, Charlotte Girard-Guyonvarc’h, Charlotte Girard-Guyonvarc’h, Charlotte Girard-Guyonvarc’h, Assunta Caruso, Assunta Caruso, Assunta Caruso, Emiliana Rodriguez, Emiliana Rodriguez, Emiliana Rodriguez, Cem Gabay, Cem Gabay, Cem Gabay   +17 more
doaj   +5 more sources

Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases [PDF]

Biomedicines, 2022
Natural soluble antagonist and decoy receptor on the surface of the cell membrane are evolving as crucial immune system regulators as these molecules are capable of recognizing, binding, and neutralizing (so-called inhibitors) their targeted ligands ...
Seung Yong Park, Yasmin Hisham, Hyun Mu Shin, Su Cheong Yeom, Soohyun Kim   +4 more
doaj   +4 more sources

A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein. [PDF]

PLoS Pathogens, 2012
Interleukin 18 (IL18) is a cytokine that plays an important role in inflammation as well as host defense against microbes. Mammals encode a soluble inhibitor of IL18 termed IL18 binding protein (IL18BP) that modulates IL18 activity through a negative ...
Brian Krumm, Xiangzhi Meng, Zhixin Wang, Yan Xiang, Junpeng Deng   +4 more
doaj   +4 more sources

Interleukin-18 binding protein deficiency results in gut microbiota dysbiosis and aggravated diet-induced MASH in mice [PDF]

JHEP Reports
Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH) are now the most prevalent hepatic disorders worldwide.
Emmanuel Somm, Elodie Perroud, Yunju Jo, Karina Lindner, Frédérique Ino, Sophie A. Montandon, Christelle Veyrat-Durebex, Franck Bontems, Florian Visentin, Nadia Gaïa, Vladimir Lazarevic, Anne-Claude Gavin, Jacques Schrenzel, Dongryeol Ryu, Karim Gariani, Cem Gabay, François R. Jornayvaz   +16 more
doaj   +2 more sources

Acquisition of different transcriptional shear mRNA and biological function of porcine interleukin 18 binding protein in PRRSV infection [PDF]

mBio
Interleukin-18 binding protein (IL-18BP), a natural regulator molecule of the pro-inflammatory cytokine interleukin-18 (IL-18), plays an important role in regulating the expression of the cellular immunity factor interferon-γ (IFN-γ).
Hong-zhe Zhao, Chun-yu Liu, Qian-jin Song, Hao Guo, Yong-jun Wen, Feng-xue Wang   +5 more
doaj   +2 more sources

Targeting highly attenuated IL-18 to PD-1 for enhanced anti-tumor activity [PDF]

Frontiers in Immunology
Checkpoint inhibitors targeting the PD-1/PD-L1 axis have revolutionized cancer immunotherapy, yet response rates remain limited. To enhance efficacy, next-generation approaches target T cell-activating cytokines to PD-1 via antibodies.
Xueyuan Zhou, Felix Klaus Geyer, Jeffrey Takimoto, Harald Kolmar, Harald Kolmar, Brian Rabinovich   +5 more
doaj   +2 more sources

Predicted IL-18/IL-18R Binding Improvement Through Protein Interface Modification with Computer-Aided Design [PDF]

Biomolecules
Cytokine-mediated immunotherapy has rapidly emerged as an effective alternative approach for cancer treatment by modulating the anti-tumor response.
Napat Prompat, Chariya Peeyatu, Jirakrit Saetang, Niran Roongsawang, Surasak Sangkhathat, Varomyalin Tipmanee   +5 more
doaj   +2 more sources

A small non-interface surface epitope in human IL18 mediates the dynamics and self-assembly of IL18-IL18BP heterodimers

Computational and Structural Biotechnology Journal, 2023
Interleukin 18 (IL18) is a pro-inflammatory cytokine that modulates innate and adaptive immune responses. IL18 activity is tightly controlled by the constitutively secreted IL18 binding protein (IL18BP).
Yılmaz Yücehan Yazıcı, Serkan Belkaya, Emel Timucin   +2 more
doaj   +1 more source

Aptamer-based multiplexed proteomic technology for biomarker discovery [PDF]

, 2010
Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands
A Keller, AD Ellington, AI Nesvizhskii, Alana Sterkel, Alex Stewart, Alexey Wolfson, Allison Weiss, Andrew B. Dalby, AS Levey, AS Levey, Ashley Bock, Ashley Forbes, AW Bell, B Schweitzer, BE Eaton, Bharat Gawande, Brian Hicke, Bridget Lollo, Britta Singer, Bruce E. Eaton, C Borrebaeck, C Tuerk, Cate Fowler, Chi Zhang, Christopher Bock, D Schneider, D Venturoli, D Zichi, D Zichi, Dan Nieuwlandt, Daniel I. Resnicow, Daniel Levine, Daniel Schneider, Deborah Ayers, Dennis Halladay, Dom Zichi, Dylan Flather, Edward N. Brody, EN Brody, ES Gragoudas, Evaldas Katilius, Fabrizio Gelain, Glenn Sanders, Gregory Husar, HK Binz, IC van Riemsdijk-van Overbeeke, J Ninio, J Ruckman, J Silberring, JD Vaught, JD Vaught, Jeff Carter, Jeffrey J. Walker, Jennifer Bertino, Jim Heil, JJ Hopfield, Joe Heilig, John Rohloff, Jonathan D. Vaught, K Chaudhary, L Gold, L Liotta, LA Gugliotti, LA Stevens, Larry Gold, Luke Kroiss, M Famulok, M Pascual, Magda Gunn, Malti Nikrad, Martin Stanton, Matt Otis, Meredith Goss, Michele Nelson, Mike Mehan, Mike Vrkljan, Mike Watrobka, Nancy Kim, Nebojsa Janjic, Ngan Le, P Mitchell, R Aebersold, R Craig, R Vanholder, Rachel M. Ostroff, RD Jenison, RF Service, RM Ostroff, Robert Mehler, S Fredriksson, S Pan, SA Doggrell, Sally K. Nelson, Sarah Sattin, Shashi Gupta, Sheela Waugh, Sheri K. Wilcox, Stephan Kraemer, Steve Pietrasiewicz, Steven K. Wolk, Susan Jennings, Suzanne Stratford, SV Giannelli, T Dewey, TA Addona, Tad H. Koch, Thale Jarvis, Thomas Parker, Tim Fitzwater, TL Nickolas, TM Tarasow, Tracy R. Keeney, Trudi Foreman, Urs Ochsner, Wes Lindsey, Wes Mayfield   +115 more
core   +13 more sources

IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis.

PLoS ONE, 2021
Idiopathic pulmonary fibrosis is a chronic, fibrosing interstitial pneumonia that presents with various clinical courses and progression ranging from rapid to slow.
Yu Nakanishi, Yasushi Horimasu, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Takeshi Masuda, Taku Nakashima, Shintaro Miyamoto, Hiroshi Iwamoto, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori   +11 more
doaj   +1 more source