Interleukin-31 as a Clinical Target for Pruritus Treatment [PDF]
Frontiers in Medicine, 2021 In recent years, the published literature has suggested the key involvement of the cytokine interleukin-31 (IL-31) in the symptomatology of pruritus, and both IL-31 and its receptor have become potential therapeutic targets for a range of pruritic ...
Kenji Kabashima, Hiroyuki Irie
doaj +6 more sources
Interleukin-31 and Chronic Pruritus of Unknown Origin [PDF]
Biomarker Insights, 2020 Chronic pruritus of unknown origin (CPUO) is a refractory condition. The expression of Interleukin-31 (IL-31), a major pruritogenic cytokine, in CPUO patients has not been investigated.
Kanin Salao +4 more
doaj +6 more sources
Interleukin-31 Signaling Bridges the Gap Between Immune Cells, the Nervous System and Epithelial Tissues [PDF]
Frontiers in Medicine, 2021 Pruritus represents one of the most common symptoms in dermatology and general medicine. Chronic pruritus severely impairs the quality of life of affected patients.
Jana Maria Nemmer +8 more
doaj +3 more sources
In chronic spontaneous urticaria, IgE and C‐reactive protein are linked to distinct microRNAs and interleukin‐31 [PDF]
Clinical and Translational Allergy, 2023 Background Chronic spontaneous urticaria (CSU) is a common and disabling disease. Assessments of IgE and C‐reactive protein (CRP) are recommended in the diagnostic work‐up, but the role and clinical relevance of these biomarkers are not well ...
Ozge Sevil Karstarli Bakay +6 more
doaj +3 more sources
Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching [PDF]
Frontiers in Immunology, 2023 BackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intermittent itchy rash. Type 2 inflammatory cytokines such as interleukin (IL)-4, IL-13, and IL-31 are strongly implicated in AD pathogenesis.
Masataka Suehiro +10 more
doaj +3 more sources
Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis [PDF]
Nature Communications, 2021 Systemic sclerosis (SSc) disease involves multisystem fibrosis and autoimmunity with limited treatment options. Here the authors demonstrate that IL-31 and IL-31RA are overexpressed in dermal fibroblasts from SSc patients and show that fibrosis and ...
Ai Kuzumi +14 more
doaj +3 more sources
Tuning SLOCK toward Chronic Disease Diagnostics and Management: Label-free Sweat Interleukin-31 Detection [PDF]
ACS Omega, 2021 SLOCK (sensor for circadian clock) is an electrochemical sweat-based biosensing platform designed for the diagnosis and management of circadian abnormalities.
Sayali Upasham, Shalini Prasad
doaj +3 more sources
Interleukin-31 Receptor α Is Required for Basal-Like Breast Cancer Progression [PDF]
Frontiers in Oncology, 2020 Purpose: Interleukin-31 receptor α (IL31RA) usually mediates IL-31 induced inflammation and allergic diseases. However, the functional roles of IL-31/IL31RA signaling in basal-like breast cancer (BLBC) progression remain totally unclear.Methods ...
Yanling He +6 more
doaj +3 more sources
Interleukin-31 Receptor A Expression in the Dorsal Root Ganglion of Mice with Atopic Dermatitis. [PDF]
Int J Mol Sci, 2023 Atopic dermatitis (AD) is a common skin disease caused by genetic and environmental factors. However, the mechanisms underlying AD development remain unclear.
Arai I, Saito S.
europepmc +2 more sources
Effects of Omalizumab on Serum Levels of Substance P, Calcitonin Gene-Related Peptide, Neuropeptide Y, and Interleukin-31 in Patients with Chronic Spontaneous Urticaria. [PDF]
Mediators Inflamm, 2023 The mechanism of action of omalizumab in urticaria is still not literally known. This study examines the serum values of substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), and interleukin-31 (IL-31) in patients using ...
Boyvadoglu C +6 more
europepmc +2 more sources