Results 31 to 40 of about 948,768 (269)

The “Intermediate” CD14 + CD16 + monocyte subpopulation plays a role in IVIG responsiveness of children with Kawasaki disease

Pediatric Rheumatology Online Journal, 2021
Background Kawasaki disease (KD) is an acute, self-limited febrile illness of unknown cause. Intravenous immunoglobulin (IVIG)-resistance are related to greater risk for permanent cardiac complications.
Yi Seul Kim, Hyun Jin Yang, Seung-Jung Kee, Insu Choi, Kisoo Ha, Katrina K Ki, In Seok Jeong, Hwa Jin Cho   +7 more
doaj   +1 more source

Monocytes presenting a pro-inflammatory profile persist in patients submitted to a long-term pharmacological treatment after acute myocardial infarction

Frontiers in Physiology, 2023
Introduction: Although it is broadly known that monocyte recruitment is involved in atherosclerosis development and that, in accordance with the microenvironment, these cells can be modulated into three well-known subpopulations: Classical (CD14++CD16−),
Daniel Carneiro de Carvalho, Francisco Antonio Helfenstein Fonseca, Maria Cristina de Oliveira Izar, Ana Luíza Pereira Assunção Silveira, Izabela Dorota Tuleta, Jônatas Bussador do Amaral, Lucas Melo Neves, André Luis Lacerda Bachi, Carolina Nunes França   +8 more
doaj   +1 more source

Induction of reactive oxygen intermediates in human monocytes by tumour cells and their role in spontaneous monocyte cytotoxicity [PDF]

British Journal of Cancer, 1999
The present study examined the ability of human monocytes to produce reactive oxygen intermediates after a contact with tumour cells. Monocytes generated oxygen radicals, as measured by luminol-enhanced chemiluminescence and superoxide anion production, after stimulation with the tumour, but not with untransformed, cells.
Mytar, B, Siedlar, M, Woloszyn, M, Ruggiero, I, Pryjma, J, Zembala, M   +5 more
openaire   +2 more sources

Single-cell profiling reveals distinct subsets of CD14+ monocytes drive blood immune signatures of active tuberculosis

Frontiers in Immunology, 2023
IntroductionPrevious studies suggest that monocytes are an important contributor to tuberculosis (TB)-specific immune signatures in blood.MethodsHere, we carried out comprehensive single-cell profiling of monocytes in paired blood samples of active TB ...
Hannah Hillman, Nabeela Khan, Akul Singhania, Paige Dubelko, Ferran Soldevila, Rashmi Tippalagama, Aruna D. DeSilva, Aruna D. DeSilva, Bandu Gunasena, Judy Perera, Thomas J. Scriba, Cynthia Ontong, Michelle Fisher, Angelique Luabeya, Randy Taplitz, Gregory Seumois, Pandurangan Vijayanand, Pandurangan Vijayanand, Catherine C. Hedrick, Bjoern Peters, Bjoern Peters, Julie G. Burel   +21 more
doaj   +1 more source

Monocyte adaptations in patients with obesity during a 1.5 year lifestyle intervention

Frontiers in Immunology, 2022
BackgroundObesity is associated with chronic, low-grade inflammation, which is reflected in altered peripheral blood monocyte characteristics. The aim of this study was to analyze the monocyte subset composition (classical (CM), intermediate (IM) and non-
Eline S. van der Valk, Eline S. van der Valk, Daniël S. Mulder, Daniël S. Mulder, Tessa Kouwenhoven, Tessa Kouwenhoven, Nicole M. A. Nagtzaam, Elisabeth F. C. van Rossum, Willem A. Dik, Pieter J. M. Leenen   +9 more
doaj   +1 more source

Lymphokines Enhance the Capacity of Human Monocytes to Secrete Reactive Oxygen Intermediates [PDF]

Journal of Clinical Investigation, 1982
Supernatants from mitogen- or antigen-stimulated human blood mononuclear cells enhanced the capacity of human monocytes or monocyte-derived macrophages (MDM) to release H(2)O(2) or O(2) in response to phorbol myristate acetate or zymosan. The stimulatory effect of lymphokines (LK) lasted approximately 5 d, regardless of the time of their addition ...
A, Nakagawara, N M, DeSantis, N, Nogueira, C F, Nathan   +3 more
openaire   +2 more sources

Monocyte Phenotypes and Physical Activity in Patients with Carotid Atherosclerosis

Antioxidants, 2022
Atherosclerosis is associated with low-grade inflammation involving circulating monocytes. It has been shown that the levels of intermediate pro-inflammatory monocytes are associated with cardiovascular mortality and risk of ischemic stroke.
Mathilde Mura, Michèle Weiss-Gayet, Nellie Della-Schiava, Erica Chirico, Patrick Lermusiaux, Marie Chambion-Diaz, Camille Faes, Anaelle Boreau, Bénédicte Chazaud, Antoine Millon, Vincent Pialoux   +10 more
doaj   +1 more source

Relationships between serum HMGB1 concentration and subpopulation composition of circulating monocytes in patients with subclinical atherosclerosis

Медицинская иммунология, 2022
Chronic non-infectious inflammation of low intensity is the most important mechanism of development and progression in atherosclerosis. Under the conditions of persistent non-resolving inflammation observed in the vascular wall and atherosclerotic plaque
V. V. Genkel, I. I. Dolgushin, I. L. Baturina, A. Yu. Savochkina, K. V. Nikushkina, A. A. Minasova, L. R. Pykhova, A. S. Kuznetcova, I. I. Shaposhnik   +8 more
doaj   +1 more source

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis [PDF]

, 2011
Macrophages, which are abundant in the tumour microenvironment, enhance malignancy. At metastatic sites, a distinct population of metastasis-associated macrophages promotes the extravasation, seeding and persistent growth of tumour cells.
Pollard, Jeffrey W, Zhang, Hui, Jeffrey W. Pollard, Jiufeng Li, Bin-Zhi Qian, Jinghang Zhang, Campion, Liam R, Kaiser, Elizabeth A, Liam R. Campion, Zhang, Jinghang, Snyder, Linda A, Kitamura, Takanori, Qian, Binzhi, Li, Jiufeng, Elizabeth A. Kaiser, Takanori Kitamura, Linda A. Snyder, Hui Zhang   +17 more
core   +1 more source

Pregnancy and preeclampsia affect monocyte subsets in humans and rats. [PDF]

PLoS ONE, 2012
INTRODUCTION: Both nonclassical and intermediate monocytes have been implicated in different inflammatory conditions. We hypothesized that these monocytes would increase during pregnancy, a condition associated with generalized activation of inflammatory
Barbro N Melgert, Floor Spaans, Theo Borghuis, Pieter A Klok, Bart Groen, Annemarie Bolt, Paul de Vos, Maria G van Pampus, Tsz Y Wong, Harry van Goor, Winston W Bakker, Marijke M Faas   +11 more
doaj   +1 more source