Results 91 to 100 of about 145,959 (288)
Advanced Science, EarlyView.This cross‐species study reveals that pathological hyperactivity of BNST neurons in depressive states disrupts inhibitory period and isolated spikes in the BNST‐NAc circuit. DBS achieves its antidepressant effects by precisely restoring network inhibitory periods and high‐fidelity signal transmission.
Xin Lv +12 more
wiley +1 more source
Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease. [PDF]
, 2019 Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts.
Huang, Yadong +2 more
core +1 more source
Disruption of Interneuron Development [PDF]
Epilepsia, 2005 Summary: Disruption of gamma‐aminobutyric acid (GABAergic) interneuron development during the embryonic and early postnatal periods can have profound neurological and behavioral consequences. Hepatocyte growth factor/scatter factor (HGF/SF) has been identified as an important molecular cue that may guide the movement of interneurons from their ...
openaire +2 more sources
Advanced Science, EarlyView.This study presents a wireless, non‐invasive strategy for neural repair by developing a biodegradable piezoelectric dural patch that, under transcranial ultrasound, generates localized electrical fields to drive endogenous neural stem cells toward neuronal differentiation and functional integration.
Pengbo Zhou +7 more
wiley +1 more source
Heterogeneity and Diversity of Striatal GABAergic Interneurons: Update 2018
Frontiers in Neuroanatomy, 2018 Our original review, “Heterogeneity and Diversity of Striatal GABAergic Interneurons,” to which this is an invited update, was published in December, 2010 in Frontiers is Neuroanatomy. In that article, we reviewed several decades’ worth of anatomical and
James M. Tepper +5 more
doaj +1 more source
A Local Circuit Model of Learned Striatal and Dopamine Cell Responses under Probabilistic Schedules of Reward [PDF]
, 2007 Before choosing, it helps to know both the expected value signaled by a predictive cue and the associated uncertainty that the reward will be forthcoming. Recently, Fiorillo et al.
Bullock, Daniel, Tan, Can Ozan
core +1 more source
PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping
Advanced Science, EarlyView.scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su +7 more
wiley +1 more source
Frontiers in Behavioral Neuroscience, 2019 Somatostatin (SOM) and somatostatin receptors (SSTR1–4) are present in all olfactory structures, including the olfactory bulb (OB), where SOM modulates physiological gamma rhythms and olfactory discrimination responses.
Sonia Nocera +14 more
doaj +1 more source
Guided Graph Spectral Embedding: Application to the C. elegans Connectome
, 2019 Graph spectral analysis can yield meaningful embeddings of graphs by providing insight into distributed features not directly accessible in nodal domain.
Bolton, Thomas A. W. +4 more
core +2 more sources
The cellular and synaptic architecture of the mechanosensory dorsal horn [PDF]
, 2017 The deep dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic tools for defining neuronal components and functions of the dorsal horn LTMR ...
Abraira +80 more
core +1 more source