Results 11 to 20 of about 176,830 (333)

Hippocampal GABAergic Inhibitory Interneurons. [PDF]

Physiological Reviews, 2017
In the hippocampus GABAergic local circuit inhibitory interneurons represent only ~10–15% of the total neuronal population; however, their remarkable anatomical and physiological diversity allows them to regulate virtually all aspects of cellular and circuit function. Here we provide an overview of the current state of the field of interneuron research,
K. Pelkey, R. Chittajallu, Michael T Craig, L. Tricoire, Jason C. Wester, C. McBain   +5 more
semanticscholar   +5 more sources

Cortical interneurons in autism

Nature Neuroscience, 2021
The mechanistic underpinnings of autism remain a subject of debate and controversy. Why do individuals with autism share an overlapping set of atypical behaviors and symptoms, despite having different genetic and environmental risk factors? A major challenge in developing new therapies for autism has been the inability to identify convergent neural ...
A. Contractor, I. Ethell, C. Portera-Cailliau   +2 more
semanticscholar   +5 more sources

The making of a maggot brain

eLife, 2023
The way neurons in the brain rewire in larvae as they turn to adult fruit flies sheds light on how complete metamorphosis was ‘invented’ over the course of evolution.
Andreas S Thum, Bertram Gerber
doaj   +1 more source

Medial Ganglionic Eminence Progenitors Transplanted into Hippocampus Integrate in a Functional and Subtype-Appropriate Manner. [PDF]

, 2017
Medial ganglionic eminence (MGE) transplantation rescues disease phenotypes in various preclinical models with interneuron deficiency or dysfunction, including epilepsy.
Baraban, Scott C, Hsieh, Jui-Yi
core   +1 more source

KCNQ2 channels regulate the population activity of neonatal GABAergic neurons ex vivo

Frontiers in Neurology, 2023
Over the last decade KCNQ2 channels have arisen as fundamental and indispensable regulators of neonatal brain excitability, with KCNQ2 loss-of-function pathogenic variants being increasingly identified in patients with developmental and epileptic ...
Bowen Hou, Sabato Santaniello, Anastasios V. Tzingounis, Anastasios V. Tzingounis   +3 more
doaj   +1 more source

New insights into the classification and nomenclature of cortical GABAergic interneurons. [PDF]

, 2013
A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web ...
A Karagiannis, A von Kölliker, AK Jain, Alex Thomson, Alfonso Fairén, Andreas Burkhalter, Bernardo Rudy, Bruno Cauli, C Golgi, CC Sherwood, Chet C. Sherwood, Chris J. McBain, Concha Bielza, D Amaral, D Feldmeyer, D Hamilton, David A. Lewis, David Fitzpatrick, Dirk Feldmeyer, E Clarke, Edward G. Jones, EG Jones, G Meyer, GA Ascoli, GA Ascoli, Giorgio A. Ascoli, Gord Fishell, Gordon M. Shepherd, Guillermo González-Burgos, Gábor Tamás, Hannah Monyer, Hanno S. Meyer, Henry Markram, HS Meyer, J DeFelipe, J DeFelipe, J Pearl, J Welagen, Javier DeFelipe, Jean Rossier, JF Staiger, JH Jackson, Jochen F. Staiger, John L. R. Rubenstein, Josh Huang, JT Porter, Kathleen Rockland, KS Rockland, L Tricoire, M Marín-Padilla, Massimo Scanziani, Oscar Marín, P Rakic, P Rakic, Patrick R. Hof, Pedro L. López-Cruz, Pedro Larrañaga, PL López-Cruz, PR Hof, R Berlin, R Malach, R Tomioka, Rafael Yuste, RF Hevner, RO Duda, Ruth Benavides-Piccione, S Melzer, Sacha B. Nelson, SD Larson, Sean Hill, Shaul Hestrin, SR Cajal, Stewart Anderson, T Meynert, Tamás F. Freund, TG Chowdhury, VB Mountcastle, VC Raykar, Y Kubota, Yasuo Kawaguchi, Yoshiyuki Kubota, Yun Wang, Zoltán Kisvárday   +82 more
core   +2 more sources

A Characterization of the Electrophysiological and Morphological Properties of Vasoactive Intestinal Peptide (VIP) Interneurons in the Medial Entorhinal Cortex (MEC)

Frontiers in Neural Circuits, 2021
Circuit interactions within the medial entorhinal cortex (MEC) translate movement into a coherent code for spatial location. Entorhinal principal cells are subject to strong lateral inhibition, suggesting that a disinhibitory mechanism may drive their ...
Saishree Badrinarayanan, Saishree Badrinarayanan, Frédéric Manseau, Sylvain Williams, Sylvain Williams, Mark P. Brandon, Mark P. Brandon   +6 more
doaj   +1 more source

Higher Network Activity Induced by Tactile Compared to Electrical Stimulation of Leech Mechanoreceptors [PDF]

, 2018
The tiny ensemble of neurons in the leech ganglion can discriminate the locations of touch stimuli on the skin as precisely as a human fingertip. The leech uses this ability to locally bend the body-wall away from the stimulus. It is assumed that a three-
Fathiazar, Elham, Hilgen, Gerrit, Kretzberg, Jutta   +2 more
core   +3 more sources

Modeling interneuron-specific (IS) interneurons in hippocampus [PDF]

BMC Neuroscience, 2014
The hippocampus and cortex have a large diversity in inhibitory interneuron types. These local interneurons exert inhibitory control over neuronal populations in the hippocampus [1]. Although much is known about how hippocampal inhibitory interneurons exert control over pyramidal cells and synchronize local network activity, less is known about how the
Guet-McCreight, Alexandre, Camiré, Olivier, Topolnik, Lisa, Skinner, Frances   +3 more
openaire   +2 more sources

Interneuron development and dysfunction [PDF]

The FEBS Journal, 2021
Understanding excitation and inhibition balance in the brain begins with the tale of two basic types of neurons, glutamatergic projection neurons and GABAergic interneurons. The diversity of cortical interneurons is contributed by multiple origins in the ventral forebrain, various tangential migration routes, and complicated regulations of intrinsic ...
Jiaxin Yang, Xiong Yang, Ke Tang
openaire   +2 more sources