Results 61 to 70 of about 176,830 (333)

A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro [PDF]

, 2004
Basic cellular and network mechanisms underlying gamma frequency oscillations (30–80 Hz) have been well characterized in the hippocampus and associated structures.
A. Bibbig, A. Roopun, A. Vogt, Brumberg, Buhl, Catania, Cunningham, Draguhn, E. H. Buhl, F. E. N. LeBeau, Fisahn, Galarreta, Gibson, Gray, Grenier, H. Monyer, Hormuzdi, Lampl, Llinas, M. A. Whittington, M. O. Cunningham, Nowak, R. D. Traub, Schmitz, Segal, Steriade, Steriade, Tamas, Tam  s, Traub, Traub, Varela, Whittington, Whittington   +33 more
core   +3 more sources

Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies

eLife, 2019
Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback inhibition and have a key role in gamma oscillations and information processing.
Jonathan H Cornford, Marion S Mercier, Marco Leite, Vincent Magloire, Michael Häusser, Dimitri M Kullmann   +5 more
doaj   +1 more source

The Interneuron Class Struggle [PDF]

Cell, 2020
In this issue of Cell, Gouwens et al. establish the state of the art for defining inhibitory cell types in the mouse neocortex. By combining morphological, electrophysiological, and transcriptomic features to classify interneurons in the mouse visual cortex, this work provides a roadmap for understanding the diversity of cell types and their functional
Jacob M, Ratliff, Renata, Batista-Brito
openaire   +2 more sources

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Directed and efficient generation of calretinin interneurons from human pluripotent stem cells

Stem Cell Research & Therapy
Background Schizophrenia, autism, and epilepsy are associated with dysfunctions in cortical GABAergic interneurons. Calretinin-expressing interneurons, the most prominent type, constitute approximately 50% of human cortical GABAergic neurons and are ...
Xuewei Du, Renli Qi, Congge Li, Wenpei Zhou, Shijiao Wang, Shenxing Wei, Runzhong Wu, Yu Yin, Tianqing Li, Xiaoqing Zhu   +9 more
doaj   +1 more source

Olfactory deficits in aging and Alzheimer’s—spotlight on inhibitory interneurons

Frontiers in Neuroscience
Cognitive function in healthy aging and neurodegenerative diseases like Alzheimer’s disease (AD) correlates to olfactory performance. Aging and disease progression both show marked olfactory deficits in humans and rodents.
Kaoutar Elhabbari, Siran Sireci, Markus Rothermel, Daniela Brunert   +3 more
doaj   +1 more source

Development of Cortical Interneurons [PDF]

Neuropsychopharmacology, 2014
Inhibitory local circuit neurons (LCNs), often called interneurons, have vital roles in the development and function of cortical networks. Their inhibitory influences regulate both the excitability of cortical projection neurons on the level of individual cells, and the synchronous activity of projection neuron ensembles that appear to be a neural ...
Jianhua, Chu, Stewart A, Anderson
openaire   +2 more sources

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Relevance of Cortical and Hippocampal Interneuron Functional Diversity to General Anesthetic Mechanisms: A Narrative Review

Frontiers in Synaptic Neuroscience, 2022
General anesthetics disrupt brain processes involved in consciousness by altering synaptic patterns of excitation and inhibition. In the cerebral cortex and hippocampus, GABAergic inhibition is largely mediated by inhibitory interneurons, a heterogeneous
Iris A. Speigel, Hugh C. Hemmings Jr., Hugh C. Hemmings Jr.   +2 more
doaj   +1 more source