Results 201 to 210 of about 76,887 (294)

Rhizotomy as a treatment for hypertonia, spasticity, and dystonia

open access: yes
Developmental Medicine &Child Neurology, EarlyView.
Shashank Rajkumar, Jeffrey S. Raskin
wiley   +1 more source

Effects of acetaminophen ingestion on the torque–duration relationship and fatigability during intermittent exercise in patients with type 1 diabetes

open access: yesExperimental Physiology, EarlyView.
Abstract This study aimed to determine the effects of acute ingestion of acetaminophen (ACT) on the magnitude of exercise‐induced peripheral fatigue (ΔPtw) in patients with type 1 diabetes (T1D). In a randomized, placebo‐controlled, double‐blind design, 22 males (11 T1D and 11 control (CTR) completed 60 maximum voluntary contractions 60 min after ...
Nadia Fekih   +4 more
wiley   +1 more source

TRIP8bnano peptide prevents cAMP binding to HCN2 channels alleviating pain‐like behaviors in rats with neuropathic pain

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend We tested the hypothesis that cAMP binding to HCN2 channels in nociceptors is a causal driver of neuropathic pain by using TRIP8bnano, a synthetic peptide we previously developed as a selective antagonist of cAMP in HCN channels. TRIP8bnano effectively abolishes cAMP potentiation of HCN2 currents in small‐diameter DRG neurons and
Santiago I. Loya‐Lopez   +7 more
wiley   +1 more source

Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang   +2 more
wiley   +1 more source

The role of group III/IV afferent feedback in the ventilatory, pressor and metabolic responses to exercise in normoxia and hypoxia

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Participants completed cycling exercise with (placebo) and without (25 µg intrathecal fentanyl) intact group III/IV muscle afferent feedback in three settings: normoxia, acute hypoxia and chronic hypoxia after 7–9 days of acclimatisation (∼3800 m). Blocking afferent feedback suppressed exercise hyperpnoea across all environments,
Elliott J. Jenkins   +23 more
wiley   +1 more source

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