Results 201 to 210 of about 99,994 (292)

Optimizing Oligonucleotide Therapeutics: A Model‐Informed Drug Development Perspective

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Oligonucleotide therapies have emerged as a powerful therapeutic class, providing novel solutions for diverse diseases through antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and aptamers that specifically target and modulate gene expression or protein function. However, oligonucleotide development faces distinct challenges,
Ye Yuan, Vishnu Sharma, Venkatesh Atul Bhattaram, Xiaolei Pan, Justin Earp, Yun Wang, Jiang Liu, Hao Zhu   +7 more
wiley   +1 more source

Continuous spinal anesthesia for TURBT in a morbidly obese patient with EF of 20%: a case report. [PDF]

Future Sci OA
Nahle M, Akhrass M, Tawbe Z, Ghandour M.
europepmc   +1 more source

Expressive language and social communication abilities in children with spinal muscular atrophy type 1

Developmental Medicine &Child Neurology, Volume 68, Issue 5, Page 696-705, May 2026.
Abstract Aim To investigate parent‐reported expressive language and social communication abilities in children with spinal muscular atrophy type 1 (SMA1) treated with disease‐modifying therapies. Method This was a cross‐sectional feasibility study performed at the Dubowitz Neuromuscular Centre, London (UK), and the Centro Clinico Nemo Pediatrico, Rome (
Chiara Brusa, Bianca Buchignani, Chiara Cutri, Giorgia Coratti, Elaine Clark, Emily Johnson, Nikki Cornell, Mariacristina Scoto, Marika Pane, Eugenio Maria Mercuri, Francesco Muntoni, Giovanni Baranello, The Language and Social Communication in SMA working group, Harriet Weststrate, Emily Barritt, Laura Antonaci, Daniela Leone, Concetta Palermo, Pinki Munot, Adnan Manzur   +19 more
wiley   +1 more source

A comparative study of dexmedetomidine versus clonidine as additives for spinal anesthesia: A meta-analysis of clinical trials. [PDF]

Medicine (Baltimore)
Yang M, Zhang Y, Peng Z.
europepmc   +1 more source

Successful repair of a carpal sheath synovial hernia using a polypropylene mesh

Equine Veterinary Education, Volume 38, Issue 5, Page e228-e234, May 2026.
Summary A cob‐cross mare presented with a carpal sheath synovial hernia on the distolateral antebrachium following carpal sheath tenoscopy to treat a radial physeal exostosis and deep digital flexor tendon injury. The presumed source of pain was the weakened skin over the hernia as the intrathecal pathology identified at the initial tenoscopy had ...
S. R. L. Neild, J. D. Stack, M. D. Cullen, B. M. Curnow   +3 more
wiley   +1 more source

Fluorine‐18‐Labeled Nucleotide Analogs Targeting Ecto‐5'‐Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
Fluorine‐18‐labeled CD73 inhibitor [18F]PSB‐19427 enables noninvasive PET mapping of CD73 overexpression in triple‐negative breast (TNBC) and pancreatic cancer. For [18F]PSB‐19427, specific binding in human tumor tissues, favorable biodistribution with prolonged blood retention, robust tumor uptake, and superiority to [18F]FDG in a TNBC model ...
Clemens Dobelmann, Constanze C. Schmies, Georg Wilhelm Rolshoven, Mirko Scortichini, Stefan Wagner, Andreas Isaak, Riham M. Idris, Jennifer Dabel, Lucie Grey, Karolina Losenkova, Susanne Moschütz, Haneen Al Hroub, Antje Keim, Sandra Höppner, Jouko Sandholm, Pia Boström, Maija Hollmén, Norbert Sträter, Sven Hermann, Gennady G. Yegutkin, Kenneth A. Jacobson, Sonja Schelhaas, Christa E. Müller, Anna Junker   +23 more
wiley   +2 more sources

Targeting spinal cord perfusion pressure in acute spinal cord injury through cerebrospinal fluid drainage: A prospective multi-center clinical trial. [PDF]

PLoS Med
Gee CM, Tsang A, McKenzie M, Belanger L, Ritchie L, Ailon T, Dandurand C, Paquette S, Charest-Morin R, Dea N, Street J, Fisher CG, Wilson J, DiGiorgio A, Mac-Thiong JM, Christie S, Wilson J, Ricks C, Okonkwo D, Kwon BK.   +19 more
europepmc   +1 more source

Rethinking Corticosteroid Therapy in Pediatric Neurology. [PDF]

J Inflamm Res
Lin WS.
europepmc   +1 more source

Cerebrospinal Fluid sCD27 as a Biomarker of Neuroinflammatory Disease: A Systematic Review and Meta‐Analysis

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Neuroinflammatory diseases of the CNS are difficult to diagnose, and current CSF biomarkers lack sensitivity across conditions. Soluble CD27 (sCD27), a marker of adaptive immune activation, has emerged as a promising candidate, but its clinical utility remains uncertain.
Nadia Damholt Savino, Malene Bredahl Hansen, Amanda Marie Lund Christiansen, Sahla El Mahdaoui, Finn Sellebjerg, Jeppe Romme Christensen   +5 more
wiley   +1 more source

Non-leukemic myeloid sarcomas involving only the central nervous system: a case report and literature review. [PDF]

Front Oncol
Han W, He H, Zheng L, Liu C, Chen Y.
europepmc   +1 more source