Results 1 to 10 of about 4,736,584 (313)
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
Nature, 2013 Transient receptor potential (TRP) channels are sensors for a wide range of cellular and environmental signals, but elucidating how these channels respond to physical and chemical stimuli has been hampered by a lack of detailed structural information ...
Maofu Liao, Erhu Cao, David Julius
exaly +2 more sources
Structure of the TRPA1 ion channel suggests regulatory mechanisms
Nature, 2015 The TRPA1 ion channel (also known as the wasabi receptor) is a detector of noxious chemical agents encountered in our environment or produced endogenously during tissue injury or drug metabolism. These include a broad class of electrophiles that activate
Jean-Paul Armache +2 more
exaly +2 more sources
Structure of the mechanically activated ion channel Piezo1
Nature, 2017 Swetha E Murthy +2 more
exaly +2 more sources
Journal of Advanced Research, 2021 Introduction: Ca2+-activated Cl− channel TMEM16A is expressed in endothelial cells, and contributes to many diseases such as hypertension, blood-brain barrier dysfunction, and pulmonary hypertension.
Ke Ma +10 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2023 Transient receptor potential (TRP) channels are sensors for a variety of cellular and environmental signals. Mammals express a total of 28 different TRP channel proteins, which can be divided into seven subfamilies based on amino acid sequence homology ...
Miao Zhang +5 more
semanticscholar +1 more source
Nature Communications, 2022 Ultrasonic neuromodulation has the unique potential to provide non-invasive control of neural activity in deep brain regions with high spatial precision and without chemical or genetic modification.
Sangjin Yoo +4 more
semanticscholar +1 more source
Ion Channel Degeneracy, Variability, and Covariation in Neuron and Circuit Resilience.
Annual Review of Neuroscience, 2021 The large number of ion channels found in all nervous systems poses fundamental questions concerning how the characteristic intrinsic properties of single neurons are determined by the specific subsets of channels they express.
Jean-Marc Goaillard, E. Marder
semanticscholar +1 more source
Activation of TMEM16A Ca2+-activated Cl− channels by ROCK1/moesin promotes breast cancer metastasis
Journal of Advanced Research, 2021 Introduction: Transmembrane protein 16A (TMEM16A) is a Ca2+-activated chloride channel that plays a role in cancer cell proliferation, migration, invasion, and metastasis.
Shuya Luo +13 more
doaj +1 more source
Continuous glucose monitoring during pregnancy in healthy mice
Scientific Reports, 2021 During pregnancy, metabolic adaptations occur to maintain the balance between maternal and foetal growth, including increased insulin secretion and decreased insulin sensitivity. When the body fails to adjust, gestational diabetes mellitus develops.
Caroline Wuyts +4 more
doaj +1 more source
TRPV4: A Physio and Pathophysiologically Significant Ion Channel
International Journal of Molecular Sciences, 2020 Transient Receptor Potential (TRP) channels are a family of ion channels whose members are distributed among all kinds of animals, from invertebrates to vertebrates.
T. Rosenbaum +6 more
semanticscholar +1 more source