Results 1 to 10 of about 1,025,431 (370)
Effect of channel block on the spiking activity of excitable membranes in a stochastic Hodgkin-Huxley model [PDF]
PHYSICAL BIOLOGY 1, pp. 61-66 (2004), 2004 The influence of intrinsic channel noise on the spontaneous spiking activity of poisoned excitable membrane patches is studied by use of a stochastic generalization of the Hodgkin-Huxley model.
Chow C C +17 more
core +3 more sources
Tuning ion coordination preferences to enable selective permeation [PDF]
, 2006 Potassium (K-) channels catalyze K+ ion permeation across cellular membranes while simultaneously discriminating their permeation over Na+ ions by more than a factor of a thousand.
Aqvist +30 more
core +4 more sources
Electric Dipolar Kondo Effect Emerging from Vibrating Magnetic Ion [PDF]
Phys. Rev. Lett. 108, 247214 (2012), 2012 When a magnetic ion vibrates in a metal, it inevitably introduces a new channel of hybridization with conduction electrons and in general, the vibrating ion induces electric dipole moment. In such a situation, we find that magnetic and non-magnetic Kondo
Hotta, Takashi, Ueda, Kazuo
core +2 more sources
Comparison of Langevin and Markov channel noise models for neuronal signal generation [PDF]
, 2009 The stochastic opening and closing of voltage-gated ion channels produces noise in neurons. The effect of this noise on the neuronal performance has been modelled using either approximate or Langevin model, based on stochastic differential equations or ...
A. L. Hodgkin +15 more
core +2 more sources
Correlation studies of open and closed states fluctuations in an ion channel: Analysis of ion current through a large conductance locust potassium channel [PDF]
, 2001 Ion current fluctuations occurring within open and closed states of large conductance locust potassium channel (BK channel) were investigated for the existence of correlation.
A. Fuliński +25 more
core +2 more sources
British Journal of Pharmacology, 2007 ALEXANDER, S.P.H., MATHIE, A. & PETERS, J.A. (2007). Guide to Receptors and Channels (GRAC), 2nd edition (2007 revision). Br. J. Pharmacol., 150 (Suppl. 1), S1–S168.
S P H Alexander +2 more
openaire +4 more sources
Thorax, 2013 Effective therapies for the 10% of patients with 'severe' asthma remain elusive, while other pulmonary diseases such as idiopathic pulmonary fibrosis are currently untreatable. Many cellular processes rely heavily on signals delivered by changes in the intracellular-free Ca(2+) concentration, in many cases relying on Ca(2+) influx from the ...
Peter, Bradding, Heike, Wulff
openaire +2 more sources
Diabetologia, 1992 Insulin secretion by the pancreatic Beta cell is dependent upon transmembrane ion fluxes gated by the ATP-regulated potassium channel and the voltage regulated, L-type calcium channel. This work group examined major recent advances in the structure and modulation of ion channels and how those advances may pertain to the physiology of insulin secretion ...
W, Catterall, P N, Epstein
openaire +2 more sources
Continuous glucose monitoring during pregnancy in healthy mice
Scientific Reports, 2021 During pregnancy, metabolic adaptations occur to maintain the balance between maternal and foetal growth, including increased insulin secretion and decreased insulin sensitivity. When the body fails to adjust, gestational diabetes mellitus develops.
Caroline Wuyts +4 more
doaj +1 more source
Ion Channel - Ion Channel Interaction at Atomic Resolution [PDF]
Biophysical Journal, 2014 Multiple lines of experimental evidence highlight the lateral patchiness of bacterial and eukaryotic cellular membrane surfaces, suggesting membranes in which proteins and lipids are organized in heterogeneous domains. This corroborates the notion that membrane signaling proteins like ion channels are assembled in supramolecular clusters, in which ...
van der Cruijsen, Elwin +5 more
openaire +4 more sources