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British Journal of Pharmacology, 2004 Guide to Receptors and ChannelsSPH Alexander, A Mathie, JA PetersBritish Journal of Pharmacology (2004) 141, S71–S91.
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Scientific ReportsThe toxin AaH-II, from the scorpion Androctonus australis Hector venom, is a 64 amino acid peptide that targets voltage-gated Na+ channels (VGNCs) and slows their inactivation. While at macroscopic cellular level AaH-II prolongs the action potential (AP),
Fatima Abbas +5 more
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Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations
eLife, 2019 The devastating inherited disease cystic fibrosis (CF) is caused by mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) anion channel.
László Csanády, Beáta Töröcsik
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TRP Channels Regulation of Rho GTPases in Brain Context and Diseases
Frontiers in Cell and Developmental Biology, 2020 Neurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural plasticity of the synapse, and blood ...
Boris Lavanderos +12 more
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Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells
Particle and Fibre Toxicology, 2017 Background Silica nanoparticles (SiNPs) have numerous beneficial properties and are extensively used in cosmetics and food industries as anti-caking, densifying and hydrophobic agents.
Alicia Sanchez +9 more
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Membranes, 2022 This study was focused on the action of lantibiotic nisin on the phospholipid membranes. Nisin did not produce ion-permeable pores in the membranes composed of DOPC or DOPE. The introduction of DOPS into bilayer lipid composition led to a decrease in the
Dayana N. Chernyshova +3 more
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Multi-Channel Profile Based Artificial Neural Network Approach for Remaining Useful Life Prediction of Electric Vehicle Lithium-Ion Batteries [PDF]
, 2021 Shaheer Ansari +4 more
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Mitochondrial Ion Channels [PDF]
Annual Review of Physiology, 2007 In work spanning more than a century, mitochondria have been recognized for their multifunctional roles in metabolism, energy transduction, ion transport, inheritance, signaling, and cell death. Foremost among these tasks is the continuous production of ATP through oxidative phosphorylation, which requires a large electrochemical driving force for ...
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A missense mutation converts the Na+,K+-ATPase into an ion channel and causes therapy-resistant epilepsy [PDF]
, 2021 Sofia Ygberg +15 more
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Scentsational Ion Channels [PDF]
Neuron, 1996 Finally, but perhaps most enticing, Coburn and Bargmann also observed striking defects in the growth of sensory axons in tax-2 and tax-4 mutants. The defects were primarily expressed as an overgrowth of axonal processes, with subsets of sensory neurons displaying either inappropriate additional axonal branches or a failure to terminate upon reaching ...
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